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Self-emulsifying vaccine adjuvant and preparation thereof

The technology of vaccine adjuvant and co-emulsifier is applied in the field of self-emulsifying vaccine adjuvant and its preparation, which can solve the problems such as difficulty in preparing W/O/W type emulsion vaccine, and achieve the effects of cost reduction and good stability

Inactive Publication Date: 2005-10-12
南京艾利珂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention discloses a new self-emulsifying vaccine adjuvant and its preparation method, which solves the difficult problem of preparation of W / O / W emulsion vaccine through self-emulsification technology, and the prepared W / O / W emulsion vaccine is stable Better than W / O / W emulsion vaccines prepared by existing adjuvants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Weigh the prescription amount of emulsifier, co-emulsifier and oil phase according to the weight percentage listed in Table 5 and mix evenly to obtain the adjuvant.

[0044] Element

Embodiment 2

[0046] Weigh the prescription amount of emulsifier, co-emulsifier and oil phase according to the weight percentage listed in Table 6 and mix evenly to obtain the adjuvant.

[0047] Element

Embodiment 3

[0049] Weigh the prescription amount of emulsifier, co-emulsifier and oil phase according to the mass percentage listed in Table 7 and mix evenly to obtain the adjuvant.

[0050] Element

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PUM

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Abstract

A self-emulsifying adjuvant for vaccine is proportionally prepared from oil phase, hydrophilic surfactant, lipophilic surfactant and coemulsifier.

Description

technical field [0001] The invention relates to the field of vaccine adjuvant, in particular to a novel self-emulsifying vaccine adjuvant and a preparation method thereof. Background technique [0002] Although highly purified new vaccines have good antigen specificity and low toxicity, they have low immunogenicity and need to be used with high-efficiency adjuvants. An adjuvant is a substance that can non-specifically change or enhance the body's specific immune response to an antigen when it is injected into the animal before or at the same time as the antigen, also known as an immunopotentiator. [0003] As the development of vaccines has become increasingly complex, higher requirements have also been placed on adjuvants; for example, biochemical experts have discovered that: firstly, the effective antigens in the vaccines are purified (effective antigens usually refer to those in bacteria or viruses that can stimulate the immune response The component of the vaccine is a...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K39/39
Inventor 邢为藩
Owner 南京艾利珂药业有限公司