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Heart brain shutong dispersion tablet and its preparation method

A technology of Xinnaoshutong and dispersible tablets, which is applied in the field of Xinnaoshutong dispersible tablets and its preparation, can solve the problems of drug dissolution, absorption and slow effect, low bioavailability, slow disintegration, etc., to improve cost performance and therapeutic index, high bioavailability, and convenient administration

Inactive Publication Date: 2005-10-26
崔翼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the clinical curative effect is positive, no clinical reports of toxic and side effects
[0003] At present, the existing Xinnaoshutong oral dosage forms are mainly two kinds of ordinary tablets and capsules, but they have the problems of slow disintegration and low bioavailability, especially the slow dissolution, absorption and effective effects of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A Xinnaoshutong dispersible tablet is characterized in that it is formulated into 1000 tablets by the raw materials of the following weight ratio:

[0034] Tribulus terrestris crude saponins (calculated as furostanol saponins) 15g

[0035] Cross-linked polyvinylpyrrolidone 60g

[0036] Sodium carboxymethyl starch 25g

[0037] Hydroxypropyl Cellulose 15g

[0038] 90g microcrystalline cellulose

[0039] Magnesium stearate 2 g

[0040] Micronized silica gel 8g

[0041] A total of 1000 tablets were produced

[0042] The preparation method of Xinnaoshutong dispersible tablet of the present invention is as follows:

[0043] Take the crude saponin of Tribulus terrestris and pass it through a 40-mesh sieve, and dry it in an oven at 45°C for 3 hours; weigh the above-mentioned auxiliary materials according to the prescription amount, and dry them in an oven at 80°C for 3 hours; Mix well; adjust the tablet machine speed and pressure, adopt the powder direct tableting method...

Embodiment 2

[0046] A Xinnaoshutong dispersible tablet is characterized in that it is formulated into 1000 tablets by the raw materials of the following weight ratio:

[0047] Tribulus terrestris crude saponins (calculated as furostanol saponins) 15g

[0048] Low-substituted hydroxycellulose 50g

[0049] Sodium carboxymethyl starch 25g

[0050] Hydroxypropyl Cellulose 15g

[0051] Microcrystalline Cellulose 100g

[0052] Magnesium stearate 2 g

[0053] Silicon dioxide 8 grams

[0054] A total of 1000 tablets were produced

[0055] The preparation method of Xinnaoshutong dispersible tablet of the present invention is as follows:

[0056] Take crude saponins from Tribulus terrestris and pass through 80-mesh sieve, and dry in an oven at 45°C for 3 hours; weigh the above-mentioned auxiliary materials according to the prescription amount, and dry them in an oven at 80°C for 3 hours; Mix well; adjust the tablet machine speed and pressure, adopt the powder direct tableting method to send t...

Embodiment 3

[0059] A Xinnaoshutong dispersible tablet is characterized in that it is formulated into 1000 tablets by the raw materials of the following weight ratio:

[0060] Tribulus terrestris crude saponins (calculated as furostanol saponins) 15g

[0061] Croscarmellose Sodium 60g

[0062] Sodium carboxymethyl starch 20g

[0063] Hydroxypropyl Cellulose 15g

[0064] Microcrystalline Cellulose 95g

[0065] Magnesium stearate 2 g

[0066] Micronized silica gel 8g

[0067] A total of 1000 tablets were produced

[0068] The preparation method of Xinnaoshutong dispersible tablet of the present invention is as follows:

[0069]Take the crude saponin of Tribulus terrestris and pass it through a 100-mesh sieve, and dry it in an oven at 45°C for 3 hours; weigh the above-mentioned auxiliary materials according to the prescription amount, and dry them in an oven at 80°C for 3 hours; Mix well; adjust the tablet machine speed and pressure, adopt the powder direct tableting method to send the...

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Abstract

A medicine in the form of dispersing tablet for treating apoplexy, coronary heart disease, cerebral infarction, etc is proportionally prepared from tribulus saponin, cross-linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose and / or carboxymethyl cellulose sodium, carboxymethyl starch sodium, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, and micropowdered silica gel or SiO2.

Description

technical field [0001] The invention relates to a Xinnaoshutong oral Chinese patent medicine preparation for regulating qi and promoting blood circulation and a preparation method thereof, in particular to a Xinnaoshutong dispersible tablet with fast absorption, high curative effect, and more convenient taking and carrying and a preparation method thereof. Background technique [0002] Xinnaoshutong oral preparation has the effect of regulating qi and promoting blood circulation. It is mainly used for thoracic obstruction caused by qi stagnation and blood stasis and in the recovery period of stroke. By. And the clinical curative effect is affirmative, and there is no clinical report of toxic and side effects. [0003] At present, the oral dosage forms of Xinnaoshutong are mainly two kinds of ordinary tablets and capsules, but they have the problems of slow disintegration, low bioavailability, especially slow drug dissolution, absorption and effective effects. Therefore, th...

Claims

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Application Information

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IPC IPC(8): A61K31/7048
Inventor 崔翼
Owner 崔翼
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