Naoxinqing drip pill for treating heart drain blood vessel disease and its preparation method

A technology of cerebrovascular disease and clear drop pills, which is applied in the field of Naoxinqing drop pills for cardiovascular and cerebrovascular diseases and its preparation, can solve the bioavailability of the first-pass effect of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment, staff Physical hazards and other issues, to achieve the effects of labor protection and environmental protection, improve bioavailability, and no dust pollution

Inactive Publication Date: 2005-10-26
北京博智绿洲医药科技有限公司
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AI Technical Summary

Problems solved by technology

[0006] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicines, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic first-pass effect and low bioavailability after taking. Thus affecting the efficacy of the drug, and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] Now with several groups of specific examples, the preparation method of Naoxinqing dripping pills of the present invention will be further described.

[0026] Group 1: Tests with a single matrix

[0027] 1. Raw materials: according to the preparation method 1, the dry powder containing the active pharmaceutical ingredients of persimmon leaves of traditional Chinese medicine is prepared in advance for later use;

[0028] 2. Substrate: polyethylene glycol (1000、2000、4000、6000、8000、10000、20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0029] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0030] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain Naoxinqing Dropping Pills of different specifications.

[0031] [test results]

[0032] Experiment 1: In order to observe the dif...

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Abstract

A Chinese medicine in the form of dripping pills for treating coronary heart disease, angina pectoris, cerebral arteriosclerosis, and ischemic cerebrovascular disease is prepared from persimmon leaf and medicinal carrier. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to a medicine that can increase the blood flow of coronary artery and brain, improve the blood and oxygen supply state of heart and brain tissue, and increase the electrophoretic rate of red blood cells, and is used for treating angina pectoris of coronary heart disease, cerebral arteriosclerosis, and ischemic cerebrovascular disease. The pharmaceutical composition particularly relates to an oral preparation of the pharmaceutical composition prepared from the extract containing the active ingredient of the traditional Chinese medicine persimmon leaf, together with a pharmaceutically acceptable carrier as a matrix. Background technique [0002] According to the ministerial drug standard WS 3 -Naoxinqing Tablet prepared by the preparation method given in B-3974-98 is an oral preparation prepared from persimmon leaves as a traditional Chinese medicine raw material, which can increase blood flow in coronary arteries and brain,...

Claims

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Application Information

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Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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