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Preparation of oral local applied paster and application thereof

A topical and oral technology, applied in the field of propolis preparations in medicine, can solve the problems of difficulty in exerting a therapeutic effect, unreasonable administration carriers, and inconvenient medication for patients, so as to improve medication compliance, reduce adverse reactions, and reduce medication times. Effect

Inactive Publication Date: 2005-11-23
张帆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of oral ulcers, antibiotics, vitamins, and painkillers are currently used for treatment, but because it is difficult to diagnose the cause, the curative effect is often poor
[0003] In traditional medicine, there are rich prescriptions and treatment methods for ulcer disease, but the drug delivery carrier is often unreasonable, and it is difficult to exert the best therapeutic effect. For example, traditional Chinese medicine mostly uses powder. At the same time, it is very inconvenient for patients to take medication; in addition, traditional prescriptions are complicated in composition, large in use, and unclear in safety, and other factors also limit their use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, the preparation 1 of propolis solid dispersion

[0048] Take 100g of propolis extract dry powder, 50g of soybean lecithin, add 500ml of ethanol, heat under reflux until all samples are dissolved, filter, take the filtrate, and spray dry to obtain propolis solid dispersion.

Embodiment 2

[0049] Embodiment 2, propolis solid dispersion preparation 2

[0050] Propolis extract 20g, PEG 6000 50g, take the carrier material and heat to melt, add propolis extract, stir quickly, mix evenly, place at -20°C for rapid cooling, stand, take out and pulverize to obtain.

Embodiment 3

[0051] Embodiment 3, propolis solid dispersion preparation 3

[0052]Take 10g of propolis extract, 5g of polyvinylpyrrolidone, 0.5g of SDS, add 100ml of ethanol, heat until completely dissolved, and evaporate the solvent under reduced pressure to obtain the product.

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PUM

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Abstract

The invention provides a preparation for treating ulcerative stomatitis, which is in the form of tablet that is prepared from auxiliary materials with adhesive action, the preparation can be hydrated on the ulcer's wound surface for close contact, thus appreciably increasing the retention time of the medicament at the ulcer position, an isolation and protection action can also be achieved for the wound surface, the patient can carry out medicine-feeding himself.

Description

technical field [0001] The invention relates to the application of a propolis preparation in the field of medicine. Background technique [0002] Oral ulcer is a clinically very common oral mucosal disease, which has the characteristics of long course of disease and difficult to cure; epidemiological survey data show that the resolution of oral ulcer is about 20%, and the number of patients is huge. Current research shows that the pathogenesis of oral ulcers is extremely complex, and there are many factors that may lead to the occurrence of oral ulcers: microbial infection, genetic factors, autoimmune lesions, etc. In the treatment of oral ulcers, antibiotics, vitamins, painkillers, etc. are mainly used for treatment at present, but due to the difficulty in diagnosing the etiology, the curative effect is often poor. [0003] In traditional medicine, there are rich prescriptions and treatment methods for ulcer disease, but the drug delivery carrier is often unreasonable, and...

Claims

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Application Information

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IPC IPC(8): A61K35/644
Inventor 张帆
Owner 张帆
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