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Method and device for separating whole blood into an erythrocyte concentrate and cell-free or thrombocyte-containing plasma under gravitational force

A technology of red blood cells and concentrates, which is applied in the field of red blood cell concentrates and plasma, and can solve problems such as technical complexity

Inactive Publication Date: 2006-01-18
西比勒・拉察
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The method is also technically complex and a high proportion of plasma remains in the red blood cell concentrate

Method used

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  • Method and device for separating whole blood into an erythrocyte concentrate and cell-free or thrombocyte-containing plasma under gravitational force
  • Method and device for separating whole blood into an erythrocyte concentrate and cell-free or thrombocyte-containing plasma under gravitational force
  • Method and device for separating whole blood into an erythrocyte concentrate and cell-free or thrombocyte-containing plasma under gravitational force

Examples

Experimental program
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Effect test

example 1

[0097] Plasma separation was performed on 552 g of whole blood (hematocrit 40.8%) stored at 26° C. for 30 minutes after being drawn from blood donors. The whole blood was first passed through a leukocyte filter (LST1 from Maco Pharma), and more than 99.9% of leukocytes / platelets were removed in the leukocyte filter.

[0098] The plasma filter used was Hemaplex BT900 / C sold by Dideco.

[0099] The operating time was 30 minutes until the first stage of separation was completed. The hematocrit achieved in the first phase was 56.6%.

[0100] The distance a is 40cm (=0.4mWC), b=10cm, c=85cm.

[0101] Afterwards, the bag containing the first red blood cell concentrate solution is inverted and the second phase begins. This phase ends after 20 minutes. The resulting hematocrit was 72.1%. The hematocrit of the second erythrocyte concentrate solution was set to 41.4% by adding the supplement solution (313 g).

[0102] The net weights of the plasma and erythrocyte concentrates were...

example 2

[0105] Example 1 was repeated, first passing whole blood through a leukocyte filter and removing leukocytes outside of the filter system (see Figure 3). Then, plasma separation was performed at 32-26°C.

[0106] The operating time is about 10 ± 5 minutes until the end of the first separation. After the first separation step, the resulting hematocrit is about 55-65%.

[0107] The distance a reaches 100cm (=1mWC). The distance b is 10-20cm, and the distance c is 85-100cm.

[0108] Then, flip the bag over and reverse the direction of filtration. Thus begins the second phase. This phase ends after 15±5 minutes. A hematocrit of about 55-65% is obtained.

[0109] If passed through the device again, the hematocrit can increase to 80-85%. The resulting erythrocyte concentrate has a net weight of about 180-200 g.

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Abstract

Method for separating whole blood into a leukocyte-depleted erythrocyte concentrate and thrombocyte-containing plasma, in which method whole blood is separated in a first step into an erythrocyte concentrate and plasma in a plasma filter and is then separated into a second erythrocyte concentrate and more thrombocyte-containing plasma during the return flow through the same plasma filter, the erythrocyte concentrate obtained being mixed with an additive solution, and the entire separation system being closed on itself and sterile.

Description

technical field [0001] The invention relates to a method for separating whole blood into a leukocyte-depleted red blood cell concentrate and plasma, and a device for carrying out the method. Background technique [0002] In whole blood fractionation, the whole blood drawn from a donor is separated into individual blood components. They are mainly erythrocyte concentrates or acellular or platelet-containing plasma fractions. [0003] Currently, whole blood separation involves the application of specially designed product fields, blood separation instruments such as high-performance centrifuges or plasma filters, and the employment of specially trained personnel or plasma separators to directly obtain single or synthetic blood components. [0004] Owing to the increased quality requirements and legal regulations and at the same time taking into account the high-performance blood separators that have been developed, it is practically impossible for blood transfusion specialist...

Claims

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Application Information

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IPC IPC(8): A61M1/34A61M1/02A61M1/36
CPCA61M2001/3604A61M1/0209A61M2001/0218A61M1/3496A61M1/0218A61M1/3604
Inventor 西比勒·拉察
Owner 西比勒・拉察
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