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Selenium-rich hedgehog fungus extract preparation for treating colitis, gastritis and stomach cancer and its preparing process

A technology of Hericium erinaceus extract and colitis, which is applied in the field of Hericium erinaceus extract preparations, can solve the problems such as there is no relevant report on the industrial production of selenium-enriched Hericium erinaceus extract preparations, and achieves significant selenium enrichment effect and improved Nutritional status, easy operation effect

Active Publication Date: 2006-11-08
山西康欣药业有限公司 +1
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Problems solved by technology

According to international and domestic online and CD-ROM database searches, there is no report on the industrial production of selenium-enriched Hericium erinaceus extract preparations

Method used

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Embodiment Construction

[0027] The Hericium erinaceus used in the present invention has a strain number of 5.580, which was introduced from the China Common Microorganism Culture Collection and Management Center. Three-stage submerged fermentation culture is adopted, the fermentation process adopts aseptic operation, the extraction process adopts plate and frame separation, double-effect concentration, spray drying, and excipients are added according to the conventional process to make selenium-enriched Hericium erinaceus extract particles.

[0028] The preparation method of selenium-enriched Hericium erinaceus extract is:

[0029] A. Incline cultivation

[0030] Medium: PDA comprehensive medium + 33.3mg / 100ml sodium selenite (Na 2 SeO 3 ·5H 2 O), make the selenium content in the culture medium reach 100 μ g / ml.

[0031] Culture conditions: Culture at 25°C±1°C for 8-10 days at a constant temperature.

[0032] B. Liquid shake flask culture:

[0033] Medium: bran 5%, glucose 1%, peptone 0.1%, KH ...

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Abstract

The present invention is selenium-rich hedgehog fungus extract preparation for treating colitis, gastritis and stomach cancer. The hedgehog fungus is used as the selenium element carrier, and through deep liquid fermentation and adding Na2SeO3 .5H2O in the amount of 10-50 mg / 100ml into the mycelium and metabolite of hedgehog fungus, hedgehog fungus culturing product of selenium content of 400-700 meg / 100g is obtained. The hedgehog fungus culturing product is added with excipient and prepared into hedgehog fungus extract preparation, which has the functions of protecting gastric mucosa, improving the nutritive state of gastrointestinal tract, regulating body's immunity, inhibiting hyperpiasia, DNA copying and protein synthesis, inhibiting tumor cell growth and treating cancer.

Description

technical field [0001] The invention belongs to Hericium erinaceus extract preparation, in particular to a preparation of selenium-enriched Hericium erinaceus extract for treating colitis, gastritis and gastric cancer and a preparation method thereof. Background technique [0002] Selenium is an essential trace element for the human body. Selenium has the functions of scavenging free radicals, anti-inflammation, anti-tumor and anti-lipid oxidation. It also has functions of delaying aging and improving the body's immunity. Directly adding inorganic selenium salts in medicines and foods has low biological activity, is not only difficult to absorb, but also has toxic and side effects, and the use effect is not ideal. At present, people mainly rely on food to obtain selenium. Compared with inorganic selenium, bio-sourced organic selenium has the advantages of high absorption and utilization, safety and non-toxicity. 72% of my country's areas are selenium-deficient areas, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P1/00A61P1/04A61P35/00C12N1/14
Inventor 郭战平赵金芬张经国张巧香李良中郭秉其
Owner 山西康欣药业有限公司
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