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Temp-sensitive, slow-releasing gel used for local injection, and its preparation method

A technology of slow-release gel and local injection, which is applied in the field of medicine, can solve problems such as incompatibility of infusion equipment, side effects of the gastrointestinal tract, and severe allergic reactions, and achieve convenient administration, improved stability, and simple preparation process Effect

Inactive Publication Date: 2010-11-10
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are many problems in this preparation, such as poor stability after dilution, severe allergic reactions, and incompatibility with infusion equipment made of polyoxyethylene, etc.
Similar to paclitaxel, non-steroidal anti-inflammatory drugs have very low solubility in water, and long-term use of non-steroidal anti-inflammatory drugs may cause serious gastrointestinal side effects

Method used

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  • Temp-sensitive, slow-releasing gel used for local injection, and its preparation method
  • Temp-sensitive, slow-releasing gel used for local injection, and its preparation method
  • Temp-sensitive, slow-releasing gel used for local injection, and its preparation method

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Abstract

A temp-sensitive slow-release gel for local injection features that when its temp is lower than that of human body, it exists in liquid state and after it is injected into human body, it becomes gel for slowly releasing its medicine component. Its preparing process includes such steps preparing the temp-sensitive polymer as carrier from PLGA-PEG-PLGA block copolymer, PEG-PLGA-PEG block copolymer and poloxamer, dissolving it in water, and dissolving or dispersing the medicine in said aqueous solution.

Description

Temperature-sensitive slow-release gel for local injection and preparation method Technical field The invention belongs to the technical field of medicine, and particularly relates to a temperature-sensitive slow-release gel for local injection for local, joint cavity, parenteral and subcutaneous injection administration and a preparation method. Background technique In recent years, the sustained and controlled release drug delivery system of injection drugs has developed rapidly. This drug delivery system has the following advantages: (1) Elimination of peaks and valleys caused by intermittent dosing and uneven drug doses, at a nearly constant rate Continue to release the drug and maintain the therapeutic concentration to avoid toxic side effects due to excessive drug concentration; (2) Because the injection route does not go through the gastrointestinal absorption process and the liver's first pass effect, the bioavailability is high and individual differences are small (3)...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P23/00A61K9/00A61P35/00A61P29/00A61K47/34A61K45/00A61K47/10
Inventor 乔明曦陈大为赵秀丽
Owner SHENYANG PHARMA UNIVERSITY
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