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Process for preparing O-carboxymethyl chitosan covalent binding chemical modification electrode

A carboxymethyl chitosan and chemical modification technology, which is applied in the field of electrochemical analysis and detection, can solve the problems that it is difficult to simultaneously eliminate or reduce the influence of AA and UA determination, the interference of DA content, etc., so that the electrode modification layer is firm and easy to use. The effect of long life and convenient production

Inactive Publication Date: 2006-11-22
YANGZHOU UNIV
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Problems solved by technology

In its electrochemical determination method, since the oxidation potential of ascorbic acid (AA) and uric acid (UA) on the solid electrode that coexists with DA in the brain and body fluid is close to that of DA, and the concentration of AA and UA is higher than that of DA, the The determination of DA content will cause serious interference, so it is difficult to simultaneously exclude or reduce the influence of AA and UA on the determination of DA

Method used

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  • Process for preparing O-carboxymethyl chitosan covalent binding chemical modification electrode
  • Process for preparing O-carboxymethyl chitosan covalent binding chemical modification electrode
  • Process for preparing O-carboxymethyl chitosan covalent binding chemical modification electrode

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Embodiment Construction

[0015] Preparation of O-Carboxymethyl Chitosan Covalently Bonded Chemically Modified Electrode

[0016] The surface of the glassy carbon electrode was coated with 0.3 μm and 0.05 μm ultrafine Al 2 o 3 The suspension was polished on silk, respectively, with 1:1 HNO 3 , absolute ethanol, and ultrasonic cleaning in water for 5 minutes. Then put the GC electrode in the oxidation solution (0.3g NaNO 3 with 4.5g KMnO 4 After mixing, dissolve in 40 mL concentrated H 2 SO 4 middle) for 60min, take it out and wash it with secondary water, then use 3% H 2 o 2 The solution was soaked for 30min to reduce excess KMnO 4 , then dry the electrode under an infrared lamp, then soak it in thionyl chloride for 60 minutes, take out the electrode and wash it with formic acid, then transfer it to the modification solution and soak it for 40 minutes, and finally rinse it with formic acid and secondary water in order to wash it. Remove the non-chemically bonded O-carboxymethyl chitosan adheri...

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Abstract

The disclosed preparation method for an electrode chemical modified by O-carboxylmethychitose covalence bond comprises: dipping glass-carbon electrode into O-carboxylmethychitose-formic acid solution for modification, taking out to clean with formic acid and distilled water. This invention can improve detection sensitivity for DA, can eliminate effect of AA and UA, and has long lifetime.

Description

technical field [0001] The invention relates to a preparation method of an O-carboxymethyl chitosan covalently bonded chemically modified electrode, belonging to the technical field of electrochemical analysis and detection. Background technique [0002] Dopamine (DA), also known as 3-hydroxytyramine, is a very important information-transmitting substance in the central nervous system of mammals and humans. Dysregulation of dopaminergic nerves in the brain is an important cause of schizophrenia and Parkinson's disease. Therefore, the research on its determination method is of great significance to explore its physiological mechanism and the diagnosis of related diseases. The determination of DA has always been a research hotspot in the fields of electroanalytical chemistry, biology and medicine. At present, the main methods for the determination of DA are fluorescence method, chemiluminescence method and capillary electrophoresis method. In its electrochemical determinatio...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/30
Inventor 王赪胤王志贤胡效亚
Owner YANGZHOU UNIV
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