Medication for treating cardiovascular diseases, and cerebrovascular disease

Abstract

A medicine for treating cardiovascular and cerebrovascular diseases is disclosed. Its advantages are high natural level and safety and low toxic by-effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating cardiovascular and cerebrovascular diseases made from traditional Chinese medicines and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Contains flavonoids (more than 20 kinds), terpenoids, phenols, beneficial trace elements and 17 kinds of amino acids and other active ingredients, which can reduce serum cholesterol, increase coronary blood flow, improve cerebral blood circulation, relieve smooth muscle spasm, relax bronchi and Antibacterial and other pharmacological effects. Clinically, it is not only used in the treatment of cardiovascular and cerebrovascular diseases, but also has good effects on the nervous system and respiratory system. Scientists such as France and Germany have confirmed that Ginkgo biloba extract has significant curative effects in the treatment of cer...

AI Technical Summary

Problems solved by technology

Dropping pill preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparation generally faces the following problems: 1. The pure natural degree of drop pill auxiliary materials is not high: Pill base excipients are mostly chemical synthetic products with a low degree of naturalness. It is very difficult to find new alternative base excipients, especially those with a high degree of naturalness and the determination of their preparation process, because currently common The preparation conditions required for the possible substitutes of natural matrix excipients are very harsh, and the temperature of the excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent

3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug

4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.

[0006] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production