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Effective parts of cirald daphne bark, preparation method and application thereof

An effective part, the technology of Zushimajiamin, which is applied in the application field of preparing anti-inflammatory and analgesic drugs, can solve the problems of not removing diterpenoids, lack of quality control, unscientific technology, etc., and achieve drug safety and preparation technology Simple, Irritant-Reducing Effects

Active Publication Date: 2006-12-27
GUANGZHOU LIXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these preparations are crude preparations extracted from water, the process is unscientific, the quality control is lacking, and there are often side effects such as skin irritation, because the toxic diterpenoids are not removed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 10 kg of pulverized ancestral hemp medicinal material was soaked in 15L water for 2 hours, put into a percolation barrel, collected 100L percolation liquid, concentrated, extracted three times with petroleum ether (1L, 1L and 1L), the water layer was adsorbed on AB-8 resin, Wash away the impurities with 10% ethanol, then elute with 60% ethanol, concentrate the eluate, spray dry, and obtain 510 g of the effective fraction of zushima, and the content of total coumarin is 78% as measured by spectrophotometry.

Embodiment 2

[0082] Put 10 kg of pulverized ancestral medicinal materials into the reflux device, extract 1.5 hours with 8 L, 8 L, and 6 L of 20% ethanol under reflux respectively (3 times in total), combine the extracts, concentrate under reduced pressure and evaporate the ethanol, petroleum ether-ethyl acetate Esters (1:1) were extracted three times (1L, 1L and 1L), the water layer was adsorbed on HPD-400 resin, washed with water to remove impurities, and then eluted with 70% ethanol, concentrated eluent, vacuum-dried to obtain effective Zushima Site 492g. The content of total coumarin is 85% as measured by spectrophotometry.

Embodiment 3

[0084] 10 kilograms of pulverized zushima medicinal materials were soaked in 10L of 20% ethanol for 12 hours, filtered, and the residue was soaked in 8L of 20% ethanol for 12 hours. The two soaking liquids were combined, and ethanol was recovered under reduced pressure, petroleum ether-ethyl acetate (2 : 1) extract three times (1L, 1L and 1L), the aqueous layer is directly adsorbed on XAD-4 resin, wash away impurities with 20%, then elute with 60% ethanol, concentrate the eluent, freeze-dry to obtain the The active part is 560g. The content of total coumarin measured by spectrophotometry is 90%.

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PUM

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Abstract

The invention relates to the effective site of bark of girald daphne, process for preparation and use thereof, wherein the effective site is obtained through extracting with water or water-containing lower alcohol, and refining with resin. The obtained medicament comprises daphnetin, daphnoretin, daphnetoxin and total coumarin. The obtained effective site can be used for antiphlogistic and analgesic functions and can be prepared into oral preparation, injection, and externally used preparation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations. The invention relates to an effective part of zushima and a preparation method, and the application of the effective part of zushima in the preparation of anti-inflammatory and analgesic drugs. Background technique [0002] Arthralgia refers to the disease caused by exogenous evils invading the meridians of the limbs, resulting in pain, numbness, and difficulty in flexion and extension of the extremities. Traditional Chinese medicine believes that it is due to deficiency of Wei Qi, wind, cold, and dampness take advantage of the deficiency to block the meridian, and if it is blocked, it will cause pain. Although there is a tendency of self-healing, the course of the disease is continuous. What's more, the internal and external adhesions of the joints, muscle atrophy, hinder joint activities, and bring a lot of inconvenience to work and life. According to the st...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P29/00A61P19/02A61K125/00A61K135/00
Inventor 侯文彬马莉申秀萍吴疆韩锋高静张新鑫胡金芳刘静
Owner GUANGZHOU LIXIN PHARM CO LTD
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