Bendalysine eye gel preparation and its making method

A technology of benidalysine eye and benidalysine, which is applied in the field of ophthalmic drugs, can solve the problems of high frequency and frequency of eye instillation, short drug retention time, poor drug efficacy, etc. Transient burning sensation and irritation, relief from dry eyes

Active Publication Date: 2007-01-17
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problems existing in the existing eye drops such as irritation, short drug retention time, high frequency and frequency of eye drops, and poor drug efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Bendalysine 40g

[0023] Sodium dihydrogen phosphate 24.8g

[0024] Disodium hydrogen phosphate 133.6g

[0025] Sodium chloride 35.2g

[0026] Carbomer 941 80g

[0027] Benzalkonium Chloride 0.4g

[0028] Tween-80 8ml

[0029] Lidocaine Hydrochloride 5g

[0030] Add water for injection to 8000ml

[0031] Made 1000 pieces

[0032] Take Carbomer 941 and add sterile water for injection and stir to make it fully swell to make a blank gel A for later use; after completely dissolving Bendalysine, add sodium dihydrogen phosphate, disodium hydrogen phosphate, and sodium chloride , lidocaine hydrochloride, Tween-80, stir until completely dissolved; add benzalkonium chloride to the above solution and stir until completely dissolved to obtain solution B. Filter solution B through a 0.45 μm microporous membrane, add the filtrate to the blank gel A and stir evenly, adjust the pH value to 4.5-9.0 with a pH reg...

Embodiment 2

[0034] Bendalysine 40g

[0035] Boric acid 100g

[0036] Borax 16g

[0037] Glycerin 30ml

[0038] Carbomer 940 100g

[0039] Benzalkonium Bromide 0.4g

[0040] PEG400 (polyethylene glycol 400) 10ml

[0041] Ethanol 8ml

[0042]Add water for injection to 8000ml

[0043] Made 1000 pieces

[0044] Take Carbomer 940 and add sterilized water for injection and stir to make it fully swell, and make a blank gel A for later use; after completely dissolving benzyl lysine, add boric acid, borax, glycerin, ethanol, PEG400 (polyethylene glycol) Alcohol 400), stirred until completely dissolved; add benzalkonium bromide to the above solution and stir until completely dissolved to obtain solution B. Filter solution B through a 0.45 μm microporous membrane, add the filtrate to the blank gel A and stir evenly, adjust the pH value to 4.5-9.0 with a pH regulator, and use water for injection filtered through a 0.45 μm...

Embodiment 3

[0046] Bendalysine 40g

[0047] Boric acid 100g

[0048] Anhydrous sodium carbonate 6g

[0049] Potassium chloride 50g

[0050] Polyvinyl alcohol 160g

[0051] Methylparaben 0.2g

[0052] PEG600 (polyethylene glycol 600) 8ml

[0053] Magnesium Sulfate 3g

[0054] Add water for injection to 8000ml

[0055] Made 1000 pieces

[0056] Take polyvinyl alcohol and add sterile water for injection and stir to make it fully swell to make a blank gel A for later use; after completely dissolving bendalysine, add boric acid, anhydrous sodium carbonate, potassium chloride, magnesium sulfate, PEG600 (polyethylene glycol 600), stir until completely dissolved; add methylparaben to the above solution and stir until completely dissolved to obtain solution B. Filter solution B through a 0.45 μm microporous membrane, add the filtrate to the blank gel A and stir evenly, adjust the pH value to 4.5-9.0 with a pH regulator, ...

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PUM

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Abstract

An eye gel for preventing and treating hyperglycemic cataract is proportionally prepared from bendalysin, gel matrix and pharmacologically acceptable carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an ophthalmic medicine, in particular to a bendallysine ophthalmic gel preparation for preventing and treating cataract and a preparation method thereof. Background technique [0002] Cataract is the leading cause of blindness. The World Health Organization estimates that blindness due to cataracts reaches 50% (1.7 million) in the world. With the prolongation of human life expectancy, aging is increasing day by day, and by 2010, the number of people blinded by cataracts will increase exponentially. In my country, according to the estimation of the health department, there are 400,000 cases of new cataract patients every year, and it ranks first among the blinding eye diseases in our country. According to a national sample survey, there are approximately 5 million cataract patients with a corrected visual acuity of 0.3 in both eyes nationwide, with a cumulative increase of 400,000 to 1.2 million new catara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/416A61K47/30A61P27/12
Inventor 杨若方春梅耿海明周建明
Owner 湖北远大天天明制药有限公司
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