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Process for extracting tanshinone II A, cryptotanshinone, dihydro tanshinone and tanshinone I

A technology for extracting cryptotanshinone dihydrotanshinone salvia miltiorrhiza and tanshinone, which is applied in the fields of steroids and organic chemistry, and can solve the problems of low proportion of finished products, large amount of raw materials, time-consuming and other problems

Inactive Publication Date: 2007-04-11
王忠东 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the extraction method of tanshinone is to use raw medicinal materials to obtain tanshinone IIA cryptotanshinone dihydrotanshinone tanshinone I, which is usually obtained by the method of upper column layer, and the proportion of the finished product that can be extracted is too low, and it is time-consuming And a large number of raw materials, many scientific researchers also try to obtain substances by other methods, the Chinese application (patent) number CN 200410014137.9 application date 2004.02.23 publication (announcement) number CN1560000

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take commercially available 10-30% tanshinone extract, heat and dissolve it completely with 5-7 times the amount of ethyl acetate at 60°C, take 160-200 mesh silica gel H mixing sample with 2-3 times the amount of tanshinone extract, sample 50- Dry at 65°C for 2-3 hours.

Embodiment 2

[0029] Take twice the amount of 160-200 mesh silica gel H of the sample, put it into the bottom of a stainless steel chromatography column with a diameter of 35-50cm and a height of 35-50cm, flatten it, and then put the sample into a stainless steel column with a diameter of 35-50cm and a height of 35-50cm On the silica gel H in the chromatography column, flatten it, cover the top with a layer of absorbent cotton, put a layer of stones to compact it, use 10-20 times the amount of benzene:ethyl acetate 19:1 to elute, and recover the eluent at normal pressure to dried to obtain crude tanshinone extract.

Embodiment 3

[0031] Put the crude tanshinone extract into a stainless steel barrel, add chloroform, heat to boiling, filter under reduced pressure, dissolve the filter residue with ethyl acetate, mix the sample with silica gel after dissolution, dry the sample, and set aside. Put the silica gel into the bottom of the stainless steel column, flatten it, put the spare sample into the column, press it flat, cover the top with a layer of absorbent cotton, press it with a layer of stones, and then use petroleum ether and ethyl acetate Add it into the column for elution, recover the eluent to dryness under normal pressure, collect the remaining tanshinone and crystallize it with ethyl acetate to obtain tanshinone IIA with a purity of 98%. Keep the above filtrate for later use.

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PUM

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Abstract

Generally, tanshinone IIA, cryptotanshinone, dihydro tanshinone and tanshinone I are obtained through column chromatography, which has too lower content of effective component in the product, and is time consuming and material consuming. The present invention provides tanshinone IIA, cryptotanshinone, dihydro tanshinone and tanshinone I extracting process including column chromatography and simultaneous extraction with ethyl acetate, silica gel H, benzene, chloroform and 60-90# petroleum ether, and the extracting process has effectively raised content of effective component in the product.

Description

Technical field: [0001] The invention relates to an extraction method, especially a method for extracting tanshinone IIA cryptotanshinone dihydrotanshinone tanshinone I. Background technique: [0002] At present, the extraction method of tanshinone is to use raw medicinal materials to obtain tanshinone IIA cryptotanshinone dihydrotanshinone tanshinone I, which is usually obtained by the method of upper column layer, and the proportion of the finished product that can be extracted is too low, and it is time-consuming And a large number of raw materials, many scientific researchers also try to obtain substances by other methods, the Chinese application (patent) number CN 200410014137.9 application date 2004.02.23 publication (announcement) number CN1560000 [0003] Public (announcement) day 2005.01.05 [0004] Application (Patent) No. CN 200410018760.1 Application Date 2004.03.17 Publication (Announcement) No. CN 1670019 [0005] Public (announcement) day 2005.09.21 [0006...

Claims

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Application Information

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IPC IPC(8): C07J73/00
Inventor 王忠东陈小亲
Owner 王忠东
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