Injection preparation and use

A technology of injection needles and injections, applied in the field of biomedicine, can solve the problems of epilepsy mechanism not very clear, patient injury and pain, behavior out of control, etc., and achieve the effect of small drug dosage, no drug residue, and fast action

Inactive Publication Date: 2007-06-13
韩苏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Epilepsy patients have no difference in performance between seizures and normal people, but sudden onset, loss of behavior control, unconsciousness, and convulsions cause serious injury and pain to the patient
The mechanism of TRH treatment of epilepsy is not very clear, but it is a fact that it has obvious control and therapeutic effects on severe epilepsy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] According to the preparation process of the prescription, three batches of TRH freeze-dried powder for injection were prepared, and the qualified rate of the finished product was greater than 90%. Randomly sample and test the physical and chemical properties, related substances, content, heat source, and bacterial content of the finished product.

[0026] It is required that the content of different batches of preparations is basically the same as the marked amount, that the related substances have no obvious changes before and after preparation, are sterile, have no pyrogen, and the vascular irritation, hemolysis and allergy tests are all negative.

[0027] Sources and quality specifications of raw and auxiliary materials:

[0028] Raw materials

quality specification

source

purpose

TRH 1

Mannitol

Sodium dihydrogen phosphate

Disodium phosphate

Water for Injection

activated carbon for needles

meet provisional standards...

Embodiment 1

[0043]For shock patients with craniocerebral injury, TRH (lyophilized powder injection 200ug / ampule) was slowly injected intravenously. 200ug each time, give the second injection 12 hours later, the dose is the same as above. Observe patient closely. 2 times a day, 3 days as a course of treatment. The TRH in the ampoule can be dissolved with 2ml of normal saline for injection, and the solution can be drawn out of the ampoule with a syringe and injected directly into the vein of the patient, or can be directly added to the normal saline or glucose injection that the patient is dripping into the vein together. Closely observe the patient's reaction and condition, and stop the injection immediately if symptoms such as palpitations, sweating, fatigue, and tremor are found in the patient.

Embodiment 2

[0045] Give epilepsy patients intravenous injection of TRH (water injection 200ug / ml / ampule) 200ug, give the second injection 12 hours later, the dose is the same as above. Observe patient closely. 2 times a day, 3 days as a course of treatment. The TRH solution in the ampoule can be drawn out with a syringe and injected into the patient's vein, or it can be directly added to the normal saline or glucose injection that the patient is dripping into the vein together. Observe patient's reaction and condition closely. If the patient is found to have symptoms such as palpitations, sweating, fatigue, and tremors, the injection should be stopped immediately.

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PUM

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Abstract

The present invention relates to an injection preparation containing thyrotropin releasing hormone (TRH). The effective component contained in said injection preparation is an artificially-synthetic 3 peptide substance, it is made up by connecting pyroglutamic acid, histidine and praline, its chemical composition is pGlu-His-Pro, its molecular formula is C16H21N5O5 and its molecular weight is 363.4 daltons. Said injection preparation can be used for curing the diseases due to HRH neurohormone imbalance, epilepsia, depression and others.

Description

technical field [0001] The present invention relates to the application of a kind of synthetic thyrotropin releasing hormone (ThyrotropinReleasing Hormone, abbreviated TRH), its chemical composition is by pyroglutamic acid-histidine-proline (pGlu-His-Pro), molecular weight is 363.4 Daltons, molecular formula C 16 h 21 N 5 o 5 3-peptide substances. The substances containing TRH components are prepared into injections for the treatment of diseases caused by the imbalance of TRH neurohormones. It can be used clinically for anti-shock and wakefulness promotion, epilepsy, depression, postpartum lack of milk, and children's mental retardation. Treatment. The invention belongs to the field of biomedicine. technical background [0002] Thyrotropin-releasing hormone (TRH) is a tripeptide substance secreted by the hypothalamus, and it is also the smallest functional peptide fragment found so far. It reaches the anterior pituitary through the pituitary-portal system, and it has t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/08A61K38/22A61P15/14A61P25/08A61P25/24A61P25/00A61P43/00
Inventor 韩苏
Owner 韩苏
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