Oral dissolved Brufen tablet and its preparing method

An oral and ethanol aqueous solution technology, applied in the directions of pill delivery, non-active components of polymer compounds, non-central analgesics, etc., can solve the problems such as there is no preparation method for ibuprofen oral dissolving tablets, reduce adverse reactions, improve Solubility and absorption, effect of increased contact area

Inactive Publication Date: 2007-06-27
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on ibuprofen oral dissolving tablet and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation method of ibuprofen oral dissolving tablet, the steps are: dissolving 1 mass part of ibuprofen in 1 mass part of 95% ethanol aqueous solution, and then adding it into the aqueous solution of hydrophilic auxiliary materials, Mix evenly, the aqueous solution of hydrophilic adjuvant consists of 3 parts by mass of glycine with a mass percent concentration of 30%, 0.16 parts by mass of animal gelatin with a mass percent concentration of 30%, 3 parts by mass of a mass percent concentration of 30% Polyethylene glycol 4000, sub-packed in non-toxic plastic blisters, freeze-dried to remove moisture, obtained.

Embodiment 2

[0017] A preparation method of ibuprofen orally dissolving tablets, the steps are: dissolving 1 mass part of ibuprofen in 3 mass parts of dehydrated alcohol, then adding it into an aqueous solution of hydrophilic auxiliary materials, mixing Uniform, the aqueous solution of the hydrophilic auxiliary material consists of 3 mass parts of poloxamer with a mass percentage concentration of 50%, 0.1 mass parts of sodium alginate with a mass percentage concentration of 50%, and 2 mass parts of It is made of 50% polyethylene glycol 6000, packed in non-toxic plastic blisters, freeze-dried to remove moisture, and obtained.

Embodiment 3

[0019] A preparation method of ibuprofen orally dissolving tablets, the steps are: dissolving 1 mass part of ibuprofen in 2 mass parts of dehydrated ethanol with mass percent concentration, then adding it into an aqueous solution of hydrophilic auxiliary materials, mixing Evenly, the aqueous solution of the hydrophilic auxiliary material is composed of 3 parts by mass of glycine with a mass percent concentration of 40%, 3 parts by mass of lactose with a mass percent concentration of 40%, and 0.16 parts by mass of 40% animal Gelatin, 3 parts by mass of polyethylene glycol 6000 with a mass percent concentration of 40%, are sub-packed in non-toxic plastic blisters, and freeze-dried to remove moisture to obtain the product.

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PUM

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Abstract

The oral dissolved Brufen tablet is prepared through the following steps: dissolving Brufen of 1 weight portions in alcohol or 95 % concentration water solution of alcohol in 1-3 weight portions, adding to 30-50 % concentration water solution of hydrophilic supplementary material in 5-12 weight portions through homogeneous mixing, packing in non-toxic plastic bubble cap, and freeze drying. The oral dissolved Brufen tablet is dissolved and dispersed in oral cavity, and thus has great contact area to gastric wall, lower medicine concentration in stomach, less stimulation to stomach, raised solubility and absorption, less untoward reactions and high curative effect.

Description

technical field [0001] The invention relates to an orally dissolving tablet, in particular to an ibuprofen orally dissolving tablet and a preparation method thereof. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory drug, which has antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects, and its curative effect is definite. However, the drug has strong gastric irritation, and gastric irritation often occurs if it is administered in conventional oral preparations such as capsules or coated tablets. In addition, due to the low density and poor fluidity of ibuprofen raw materials, problems such as sticking and punching often occur when tablets are prepared by pressing methods. More importantly, ibuprofen is a water-insoluble chemically synthesized drug, and there is a problem with the absorption in the body after oral administration of common oral solid preparations. [0003] Orally dissolving tablet is a new dosage form developed in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/192A61K47/34A61K47/38A61K47/42A61K47/26A61K47/16A61P29/00A61K47/10
Inventor 魏振平谭丽蒋建兰
Owner TIANJIN UNIV
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