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Highly effective plaster for burn and scald and its preparation process

A highly efficient technology for burns and scalds, which is applied in the directions of medical preparations, pharmaceutical formulations, and sheet delivery containing active ingredients. The effect of regeneration and improvement of immunity

Inactive Publication Date: 2007-07-04
北京尼奥克斯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although people have made great progress in the research on the role of NO in wound healing and the research on the treatment methods related to NO to promote wound healing, in the process of using the existing technology, the agents used in the promotion of wound epithelial cell generation , antibacterial and anti-inflammatory and promoting skin microcirculation, and promoting wound angiogenesis are still not ideal

Method used

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  • Highly effective plaster for burn and scald and its preparation process
  • Highly effective plaster for burn and scald and its preparation process
  • Highly effective plaster for burn and scald and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Weigh 0.1 g of sodium nitrite, add 50 ml of distilled water to fully dissolve it, add 750,0000.16 g of 2-hydroxyethyl cellulose, stir continuously for 6 hours at room temperature, and then let it stand for 24 hours until it solidifies. The gum is clear and prepared as a nitrogen gel. Nitrogen gel slowly passes through the coating equipment, and every 2 ml of nitrogen is evenly coated on the substrate. The substrate is made of air-permeable polyester polymer materials, polyolefin polymer materials, gauze or gummed paper, etc. Slitting and preparing a nitrogen drug storage layer for future use.

[0064] Weigh 0.31 grams of citric acid monohydrate and 0.26 grams of L(+)-ascorbic acid, add 50 milliliters of distilled water to make them fully dissolved, then add 750,000 0.16 grams of 2-hydroxyethyl cellulose, and stir continuously at room temperature for 3 Hours, then stand for 24 hours until the gel is clear, and it is prepared into an acid agent gel. The acid agent gel s...

Embodiment 2

[0068] A new type of high-efficiency burn and scald patch was prepared in the same way as in Example 1, but during the preparation process, the nitrogen agent gel slowly passed through the equipment, and every 2 ml of nitrogen agent was divided into 2 cm × 2 cm sealed bags , a conventional sealed bag can be used as Annex B.

[0069] The finished product includes patch (A) and attachment (B). Wherein part A is the same as part A of embodiment 1, is rectangular, and the bottom is tape layer (1), can adopt PVP tape, elastic cloth, zinc oxide tape or PU tape. In the center of the adhesive tape layer (1) is the acid agent drug storage layer (2), and the cover layer (3) is made of two self-adhesive cloths, and their outward ends are pasted with the exposed part of the adhesive tape layer (1), The inward end can cover the acid drug storage layer (2).

[0070] Usage and dosage: clean the wound surface, remove the patch from the anti-adhesive adhesive paper, open the small sealed bag...

Embodiment 3

[0072] Prepare the new high-efficiency burn and scald patch with the same method as in Example 1, but in the preparation process, the nitrogen agent gel slowly passes through the equipment, and every 2 milliliters of nitrogen agent is divided into small plastic tubes of 3 milliliters, and used Caps screw on, as accessory B.

[0073] Finished product is identical with embodiment 2.

[0074] Usage and dosage: clean the wound surface, remove the patch from the anti-adhesive adhesive paper, open the small plastic hose, spread the gel in it evenly on the acid drug storage layer, and let the drug layer stick to the wound surface, and it is ready when it is tight enough. Can.

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Abstract

The invention provides a novel efficient fire and burn injuries plaster agent and its preparation method, it achieves the purpose of the treatment of burns using the action of nitrogen agent storing drug layer(4) prepared by nitrite and acid agent storing drug layer(2) prepared by reductant.Pharmacological experiments confirmed that the new efficient fire and burn injuries plaster agent based nitric oxide in the invention can treat 1 and 2 degree fire and burn injuries and accelerate skin healing.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, relates to a medicament for treating burns and scalds, in particular to a novel high-efficiency burn and scald medicament based on nitric oxide in the form of a patch and a preparation method thereof. Background technique [0002] Burns are common traumas both in peacetime and wartime. According to medical information statistics, the number of burns and scald patients due to various reasons in my country accounts for about 7 / 1000 to 10 / 1000 of the total population in peacetime every year. Along with the raising of people's living standards and material civilization in society, the popularization of motorcycles, the use of disposable tableware and tea sets, burns and scalds are more likely to occur. [0003] At present, the burn medicines on the market are uneven, and the treatment time is long and the curative effect is slow. External drug therap...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K9/70A61P17/02
Inventor 陈振兴弗里德·穆拉德威廉·塞茨罗伯特·贾菲德安里克斯安德鲁·巴拉班兰德尔·斯图尔特
Owner 北京尼奥克斯生物科技有限公司
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