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Methods for extracting a tooth

a tooth extraction and tooth technology, applied in the field of tooth extraction methods, can solve the problems of bone tissue being removed or damaged during the procedure, fluid seepage or weeping, and other forms of fluid loss that are typically present, and achieve the effect of accelerating the restoration of the extracted tooth and reducing the risk of tooth extraction

Active Publication Date: 2018-07-10
PROTEOLEASE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]The present invention is directed to a method for reducing a risk associated with tooth extraction in a subject in need thereof, comprising applying an effective volume of a composition comprising an effective amount of an agent capable of destroying the periodontal ligament surrounding the tooth, such as, collagenase, into the periodontal ligament space of said tooth, thereby reducing the risks and excessive pain associated with tooth extraction in a subject in need thereof.
[0008]The present invention is based, in part, on the unexpected discovery that extracting a tooth by topical application, into the tissue surrounding a tooth, of an agent capable of severing the periodontal ligament surrounding the tooth, requires investing significantly less force compared to the force required for extracting a tooth using common methods. Moreover, the method of the invention ensures superior patient comfort and therefore patient compliance due to its advantageous features, such as, reduction in bleeding, reduction in tooth socket deformation, and minimal damage to the alveolar bone.
[0012]In yet another embodiment, extracting comprises applying an extraction force parallel to the long axis of said tooth, thereby minimizing damage of the tissue surrounding the tooth, bleeding and bone loss. In yet another embodiment, extracting is devoid of applying a rotational force.
[0036]In yet another embodiment, the use and method of the invention reduce a risk associated with tooth extraction in a subject in need thereof.
[0037]In yet another embodiment, the use and method of the invention accelerate restoration of the extracted tooth by permitting immediate placement of a dental implant in a subject in need thereof.

Problems solved by technology

During and after such conventional dental procedures bleeding, fluid seepage or weeping, or other forms of fluid loss typically occur.
In addition, bone tissue is being removed or damaged during the procedure.
As a result, swelling and residual bleeding persist during the healing period.
Generally, whether the injury to the surrounding tissues during extraction procedure is greater, these side effects are more pronounced.

Method used

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  • Methods for extracting a tooth
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Examples

Experimental program
Comparison scheme
Effect test

example 1

Defragmentation of Gingival Tissue In Vitro by Collagenase

[0111]A. Dimension Measurement Using a Millimetric Grid

[0112]Gingival tissue was chosen for the purpose of In vitro experiments, as it can be easily obtained at various sizes and has many common characteristics with PDL, where PDL is too thin and delicate for this kind of experiments.

[0113]A band of gingival tissue, 20×3×0.3 mm3, was obtained from the diastema region of pig mandible within a few minutes following sacrifice. The band was sliced into four equal specimens about 5×3×0.3 mm3 each (FIG. 1 and FIG. 2A).

[0114]Two specimens were conditioned in 0.5 ml of phosphate-buffered saline (PBS) containing 5450 units / ml collagenase CLPSA solution (Worthington Biochemical Corporation, NJ, USA; FIGS. 2D and 2E) and two specimens were conditioned in 0.5 ml PBS (FIGS. 2B and 2C) and served as control. All four specimens were incubated in 37° C. water bath under gentle agitation for different time intervals.

[0115]The extent of tissue...

example 2

Assessment of the Intraligamental Injection Volume Ex-Vivo

[0126]Assessment was based on empirical findings regarding the length of the teeth to be treated and the width of the periodontal ligament at specific sections. This data was used to calculate the estimated PDL volume. This estimation was then reevaluated clinically.

[0127]Indian ink was injected into the PDL of mandibular 3rd incisor and 1st premolar, at 6 points. The end point was determined by the injection volume causing dye leakage. The optimal volume was determined as 20 μl at each of the 6 points of injection.

example 3

PDL Defragmentation Following Collagenase Injection

[0128]In order to evaluate PDL structure rather than gingival structure, mandibular 3rd incisor and 1st premolar bilaterally and the tissue surrounding same, were subjected to enzyme injection (20 μl at 6 points) at different concentrations (2,500; 5,000; 7,500 or 10,000 units / ml). Two hours post injection the mandibles were cut and trimmed around the relevant tooth, leaving a tooth embedded in the bone socket, then fixed in formalin. Specimens were decalcified for 5-6 days, then trimmed (FIG. 5), embedded in paraffin and sectioned along the tooth's long axis.

[0129]The sections were stained with Hematoxylin & Eosin and Picrosirius Red and transferred to histopathological examination in order to test PDL collagen fibers breakdown at different sections of the root and integrity of surrounding tissues structures (alveolar bone proper). Specimen that were injected with PBS or not injected served as control.

[0130]PDL Defragmentation was ...

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Abstract

Methods of extracting teeth involving contacting, prior to extraction, the tissue surrounding a tooth to be extracted with a composition providing an agent capable of destroying the periodontal ligament surrounding the tooth, such as, collagenase.

Description

FIELD OF THE INVENTION[0001]The present invention is directed to methods of extracting teeth comprising contacting, prior to extraction, the tissue surrounding a tooth to be extracted with a composition comprising an agent capable of destroying the periodontal ligament surrounding the tooth, such as, collagenase. The present invention is further directed to method of replacing a tooth with dental implants following enzymatic extractions.BACKGROUND OF THE INVENTION[0002]Various dental procedures for extraction of a tooth are known in the art. Commonly, these methods involve luxating the tooth with dental elevator until the periodontal ligament is sufficiently broken and the supporting alveolar bone is adequately widened to make the tooth loose enough thereby ready to be removed. Removal of the tooth is usually accomplished with dental forceps through the application of intermittent apical and lateral forces. When a tooth cannot be easily accessed (e.g. because it is broken under the ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61C5/00A61K38/48A61K45/06A61C19/06A61C3/14
CPCA61K38/4886A61C19/063A61K38/48A61K45/06C12Y304/24003A61C3/14F04C2270/041C12Y304/24007A61K2300/00A61P1/02A61P41/00
Inventor MARYNKA KALMANI, KERENWEINBERG, EVGENYGAFNI, YOSEF
Owner PROTEOLEASE
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