Use of a composition containing at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer

a technology of hydrophilic active principle and polymer or copolymer, which is applied in the field of composition comprising an oxidation-sensitive active principle, can solve the problems of easy decomposition on contact with water, conflict with desired effect, and inability to be stable in aqueous medium, and achieve good cosmetic effect, retain the depigmenting and/or lightening ability of the active principl

Inactive Publication Date: 2003-07-03
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0013] One object of the present invention is to provide a composition comprising an oxidation-sensitive active principle selected from the group consisting of ascorbic acid and its derivatives, which exhibits good cosmetic pr

Problems solved by technology

However, some of these active principles exhibit the disadvantage of being unstable in an aqueous medium and of easily decomposing on contact with water, in particular because of oxidation phenomena.
They thus rapidly lose their activity over time and this instability conflicts with the desired effectiveness.
Unfortunately, because of its chemical structure (of .alpha.-ketolactone), ascorbic acid is highly sensitive to certain environmental parameters and in particular to oxidation phenomena

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0081] Accelerated Storage Test.

[0082] The aim of this test is to study the decomposition of an oxidation-sensitive hydrophilic active principle after storing for two months at 45.degree. C. Various solutions were prepared and their compositions are collated in the following table:

1TABLE I Compositions (in Solution A water) (Control) Solution B Solution C Solution D Ascorbic acid 15% 15% 15% 15% Polymer 1 -- 1% -- --Polymer 2 -- -- 1% --Polymer 3 -- -- -- 1%

[0083] All the solutions are brought to pH 6 with 8.9 mol / l KOH.

[0084] The percentages of the polymers are given as active material.

[0085] Polymer 1: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K72W of BASF (Weight-average molecular mass 1.2.times.10.sup.6).

[0086] Polymer 2: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K18P of BASF (Weight-average molecular mass 10 000).

[0087] Polymer 3: Polyvinylpyrrolidone sold under the reference Kollidon ...

example 2

[0098] Demonstration of the Activity With Regard to the Dendricity of Melanocytes:

[0099] The aim of this test is to show the effect of the combination of ascorbic acid with a polymer or copolymer according to the invention on adjusting the melanogenesis of human keratinocyte-melanocyte cocultures.

[0100] Method: The cells are treated from inoculation with the ascorbic acid / vinylpyrrolidone-vinylimidazole copolymer combinations for 7 days.

[0101] Observations:

[0102] The melanocytes are labelled using the NK1beteb antibody (green colouring), which recognizes the melanosomes at every stage of maturation. The nuclei of all the cells, melanocytes and keratinocytes, are stained using propidium iodide (red colouring).

[0103] Results:

[0104] In the absence of the ascorbic acid / vinylpyrrolidone-vinylimidazole copolymer combinations, the melanocytes in cocultures are highly dendritic. The pigment is visibly transferred to the neighbouring keratinocytes.

[0105] In the presence of the ascorbic acid / ...

example 3

[0107] O / W Anti-Blemish Cream

[0108] The following composition is prepared in a way conventional to a person skilled in the art.

3 A.sub.1 Sorbitan tristearate 0.7 g Polyethylene glycol (40 EO) stearate 1.6 g Cetyl alcohol 3.2 g Glyceryl mono-, di-, tripalmitate / stearate 2.4 g Myristyl myristate 2 g Liquid fraction of karite butter 2 g Preservative 0.2 g A.sub.2 Cyclopentadimethylsiloxane 15 g B Demineralized water 60.53 g Glycerol 3 g Ascorbic acid 5 g 50% Potassium hydroxide 3.07 g Vinylpyrrolidone / vinylimidazole copolymer 1 g Preservative 0.2 g C Fragrance 0.1 g

[0109] This cream which is soft on application makes it possible to reduce pigmentary blemishes and confers good stability on ascorbic acid.

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Abstract

The invention relates to the use of a composition contains at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its derivatives and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the said polymer or copolymer both being in the aqueous phase, for lightening and/or depigmenting the skin and/or hair, including body hair.

Description

[0001] 1. Field of the Invention[0002] The present invention relates to the use of a composition comprising at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer, preferably in a physiologically acceptable medium comprising an aqueous phase. Preferably the use is a cosmetic and / or dermatological use related to lightening or depigmenting the skin and / or the hair, and is thus preferably targeted to skin and / or hair to be lightened.[0003] 2. Background of the Invention[0004] It is known to introduce, into cosmetic compositions, various active principles intended to contribute specific treatments to the skin and / or hair. However, some of these active principles exhibit the disadvantage of being unstable in an aqueous medium and of easily decomposing on contact with water, in particular because of oxidation phenomena. They thus rapidly lose their activity over time and this instability conflicts with the desired effectiveness...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K8/02A61K8/03A61K8/06A61K8/11A61K8/18A61K8/30A61K8/31A61K8/33A61K8/34A61K8/36A61K8/365A61K8/368A61K8/37A61K8/40A61K8/41A61K8/42A61K8/44A61K8/46A61K8/49A61K8/55A61K8/58A61K8/60A61K8/63A61K8/67A61K8/68A61K8/72A61K8/73A61K8/81A61K8/84A61K8/90A61K8/92A61K8/96A61K8/97A61K31/375A61K31/695A61K31/787A61K45/00A61P17/16A61P43/00A61Q1/00A61Q5/08A61Q17/04A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/676A61K8/817A61Q19/08A61Q5/08A61Q19/02A61K2800/522A61P17/00A61P17/16A61P43/00A61K8/67A61K8/84A61K8/90
Inventor BIATRY, BRUNOLHEUREUX, ERIC
Owner LOREAL SA
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