Methods for making a device for concurrently processing multiple biological chip assays

a technology of biological chips and devices, applied in the field of concurrent processing of multiple biological chip assays, can solve problems such as inability to adapt to handling multiple samples simultaneously

Inactive Publication Date: 2005-06-09
AFFYMETRIX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they are not adapted for handling multiple samples simultaneously.

Method used

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  • Methods for making a device for concurrently processing multiple biological chip assays
  • Methods for making a device for concurrently processing multiple biological chip assays
  • Methods for making a device for concurrently processing multiple biological chip assays

Examples

Experimental program
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Embodiment Construction

I. Definitions

[0021] The following terms are intended to have the following general meanings as they are used herein:

[0022] A. Complementary:

[0023] Refers to the topological compatibility or matching together of interacting surfaces of a probe molecule and its target. Thus, the target and its probe can be described as complementary, and furthermore, the contact surface characteristics are complementary to each other.

[0024] B. Probe:

[0025] A probe is a surface-immobilized molecule that can be recognized by a particular target. Examples of probes that can be investigated by this invention include, but are not restricted to, agonists and antagonists for cell membrane receptors, toxins and venoms, viral epitopes, hormones (e.g., opioid peptides, steroids, etc.), hormone receptors, peptides, enzymes, enzyme substrates, cofactors, drugs, lectins, sugars, oligonucleotides, nucleic acids, oligosaccharides proteins, and monoclonal antibodies.

[0026] C. Target:

[0027] A molecule that has ...

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Abstract

Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a molecular probe array; introducing samples into the test wells; subjecting the biological chip plate to manipulation by a fluid handling device that automatically performs steps to carry out reactions between target molecules in the samples and probes; and subjecting the biological chip plate to a biological chip plate reader that interrogates the probe arrays to detect any reactions between target molecules and probes.

Description

BACKGROUND OF THE INVENTION [0001] This invention relates to methods for concurrently performing multiple biological chip assays. The invention therefore relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine and diagnostics. [0002] New technology, called VLSIPS™, has enabled the production of chips smaller than a thumbnail that contain hundreds of thousands or more of different molecular probes. These biological chips or arrays have probes arranged in arrays, each probe assigned a specific location. Biological chips have been produced in which each location has a scale of, for example, ten microns. The chips can be used to determine whether target molecules interact with any of the probes on the chip. After exposing the array to target molecules under selected test conditions, scanning devices can examine each location in the array and determine whether a target molecule has interacted with the probe at that location. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01J19/00B01L3/00C12M1/34C12Q1/68C12Q1/70C40B40/06C40B60/14G01N21/64G01N35/00G01N35/02
CPCB01J19/0046G01N2035/00158B01J2219/00315B01J2219/00317B01J2219/00432B01J2219/00527B01J2219/00529B01J2219/00576B01J2219/00605B01J2219/00608B01J2219/0061B01J2219/00612B01J2219/00617B01J2219/00619B01J2219/00621B01J2219/00626B01J2219/00637B01J2219/00639B01J2219/00659B01J2219/00662B01J2219/00702B01J2219/00707B01J2219/00722B01L3/5027B01L3/5085B01L3/50853B01L2300/041B01L2300/044B01L2300/046B01L2300/0636B01L2300/0819B01L2300/0829B01L2400/0683C12Q1/6837C40B40/06C40B60/14G01N21/64G01N35/028B01J2219/00286
Inventor RAVA, RICHARD P.FODOR, STEPHEN P.A.TRULSON, MARKNORVIEL, VERNON A.
Owner AFFYMETRIX INC
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