Monoclonal antibodies that specifically block biological activity of a tumor antigen

a tumor antigen and monoclonal antibody technology, applied in the field of purified novel monoclonal antibodies, can solve the problems of affecting the antibody used to kill cancer cells also has a deleterious effect on normal cells, and the survival rate of cancer cells is still less than 40%
US20050232919A1Inactive Publication Date: 2005-10-20EISAI INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
EISAI INC
Publication Date
2005-10-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims benefit of U.S. Provisional Application No. 60 / 544,364, filed Feb. 12, 2004, the content of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION

[0002] This invention relates to purified novel monoclonal antibodies that specifically bind to the alpha-folate receptor (“FR-α”) and compositions thereof. In some embodiments, the antibodies of the invention block the biological activity of FR-α. The antibodies and compositions of the invention are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor, such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to hybridoma cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, mammalian cells expressing the monoclonal antibodies,...

Claims

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