Use of creatine analogues and creatine kinase modulators for the prevention and treatment of glucose metabolic disorders

a technology of creatine kinase and analogues, which is applied in the field of use of creatine analogues and creatine kinase modulators for the prevention and treatment of glucose metabolic disorders, can solve the problems of significant drop in glucose levels in subjects
US20050256134A1Inactive Publication Date: 2005-11-17AVICENA GROUP +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
AVICENA GROUP
Publication Date
2005-11-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation application of U.S. Ser. No. 10 / 281,379, filed Oct. 25, 2002; which is a continuation application of U.S. Ser. No. 09 / 539,963, filed Mar. 31, 2000; which is a continuation application of U.S. Ser. No. 08 / 914,887, filed Aug. 19, 1997; which is a continuation-in-part application of U.S. Ser. No. 08 / 540,894, filed Oct. 11, 1995. The entire contents of each of the above-referenced applications are hereby incorporated herein by reference in their entirety.FIELD OF INVENTION

[0002] The present invention provides for new use for creatine compounds (compounds which modulate one or more of the structural or functional components of the creatine kinase / creatine phosphate system) as therapeutic agents. More particularly, the present invention provides a method of treating or preventing certain metabolic disorders of human and animal metabolism, e.g., hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, in...

Claims

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