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Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

a technology of epithelial or mucosal atrophy and inhibition of atrophy, which is applied in the direction of biocide, drug composition, sexual disorder, etc., can solve the problems of affecting the mental activities of aging women, reducing estrogen concentration, and increasing the risk of endometrial and breast cancer

Inactive Publication Date: 2005-12-08
HORMOS MEDICAL OY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"This patent is about a new compound that can be used to treat skin atrophy in women. The compound has been tested and found to be effective in preventing or treating symptoms related to this condition. The technical effect of this patent is that it provides a new tool for the treatment of skin atrophy in women."

Problems solved by technology

Thus, declining estrogen concentrations may negatively affect the mental activities of aging women (Schneider & Finch, 1997; Wickelgren, 1997).
However, estrogens cause an increased risk of endometrial and breast cancers.

Method used

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  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women
  • Methods for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

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Embodiment Construction

[0012] The methods according to this invention are particularly useful for women during or after the menopause. However, the methods according to this invention is not restricted to women in this age group.

[0013] This invention relates particularly to the use of the estrogen receptor modulator ospemifene in women during or after the menopause. Ospemifene is the Z-isomer of the compound of formula (I) and it is one of the main metabolites of toremifene, is known to be an estrogen agonist and antagonist (Kangas, 1990; International patent publications WO 96 / 07402 and WO 97 / 32574).

[0014] The term “metabolite” shall be understood to cover any (deaminohydroxy)toremifene metabolite already discovered or to be discovered. As examples of such metabolites can be mentioned the oxidation metabolites mentioned in Kangas (1990) on page 9 (TORE VI, TORE VII, TORE XVIII, TORE VIII, TORE XIII), especially TORE VI and TORE XVIII, and other metabolites of the compound.

[0015] The use of mixtures of...

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Abstract

This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The present application is a continuation of U.S. patent application Ser. No. 10 / 162,708 filed 6 Jun., 2002, which is a continuation-in-part of International Application No. PCT / FI01 / 00414 filed 2 May 2001 designating the U.S., which was published under PCT Article 21(2) in English as International Publication No. WO 02 / 07718, and which is a continuation of U.S. patent application Ser. No. 09 / 625,199, filed 21 Jul. 2000, now U.S. Pat. No. 6,245,819, each application being incorporated by reference herein in its entirety.FIELD OF THE INVENTION [0002] This invention relates to a method for the inhibition of skin atrophy, epithelial or mucosal atrophy in women, especially women during or after the menopause. The invention also concerns prevention or treatment of atrophy-related symptoms in women, especially women during or after menopause. BACKGROUND OF THE INVENTION [0003] The publications and other materials used herein to illuminate the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61P15/02A61K31/075A61K31/085A61P15/12
CPCA61K31/085A61K31/075A61P13/02A61P15/00A61P15/02A61P15/12A61P5/30
Inventor BLOM, TARUGRONROOS, PAULAHALONEN, KAIJAHARKONEN, PIRKKO
Owner HORMOS MEDICAL OY LTD
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