Antibody formulations

US20060088523A1Inactive Publication Date: 2006-04-27GENENTECH INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
GENENTECH INC
Publication Date
2006-04-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present application describes antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation comprising an antibody that binds to domain II of HER2 (for example, Pertuzumab), and a formulation comprising an antibody that binds to DR5 (for example, Apomab).
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Description

[0001] This is a non-provisional application filed under 37 CFR 1.53(b) claiming priority to provisional application 60 / 620,413 filed Oct. 20, 2004, the contents of which are incorporated herein by referenceFIELD OF THE INVENTION

[0002] The present invention concerns antibody formulations, including monoclonal antibodies formulated in histidine-acetate buffer, as well as a formulation comprising an antibody that binds to domain II of HER2 (for example, Pertuzumab), and a formulation comprising an antibody that binds to DR5 (for example, Apomab). BACKGROUND OF THE INVENTION

[0003] In the past ten years, advances in biotechnology have made it possible to produce a variety of proteins for pharmaceutical applications using recombinant DNA techniques. Because proteins are larger and more complex than traditional organic and inorganic drugs (i.e. possessing multiple functional groups in addition to complex three-dimensional structures), the formulation of such proteins poses special probl...

Claims

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