Examination of subjects using photon migration with high directionality techniques

a high-directionality, photon migration technology, applied in the direction of fluorescence/phosphorescence, instruments, applications, etc., can solve the problems of inapplicability of certain aspects of cross-sectional imaging techniques, and none of those techniques have fully satisfied all situations

Inactive Publication Date: 2008-07-03
CHANCE BRITTON
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  • Description
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  • Application Information

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Problems solved by technology

However, with lower energy radiation, such as visible or infra-red radiation, the radiation is strongly scattered and absorbed in biological tissue, and the migration path cannot be approximated by a straight line, making inapplicable certain aspects of cross-sectional imaging techniques.
None of those techniques have fully satisfied all situations.

Method used

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  • Examination of subjects using photon migration with high directionality techniques
  • Examination of subjects using photon migration with high directionality techniques
  • Examination of subjects using photon migration with high directionality techniques

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Embodiment Construction

[0057]Imaging system embodiments of the present invention based upon interference effects of radiation migrating in a subject having scattering and absorptive properties are shown in FIGS. 1, 2, and 3. The systems effectively utilize, in this scattering medium, a directional beam of visible or IR radiation generated and / or detected by an array of sources and / or detectors, respectively. For instance, in the case of an array of sources, each source is placed at a selected location in the array and emits intensity modulated radiation, preferably coherent radiation from a laser diode, of a selected intensity and phase. The criteria for selecting the source locations, the intensities, and the phases of the respective sources is the shape of the desired beam that at any time point possesses a substantial photon density gradient produced by interference effects of radiation from the various sources. This gradient of photon density is localized and has directional properties. Overall, the r...

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Abstract

A spectroscopic method and system for examination of biological tissue includes multiple input ports optically connected to at least one light source, multiple detection ports optically connected to at least one detector, a radiation pattern controller coupled to the light source and detector, and a processor. The multiple input ports are arranged to introduce light at input locations into biological tissue and the multiple detection ports are arranged to collect light from detection locations of the biological tissue. The radiation pattern controller is constructed to control patterns of light introduced from the multiple input ports and constructed to control detection of light migrating to the multiple detection ports. The processor is operatively connected to the radiation pattern controller and connected to receive detector signals from the detector, and is constructed to examine a tissue region based on the introduced and detected light patterns.

Description

BACKGROUND OF THE INVENTION[0001]This invention relates to examination and imaging of biological tissue using visible or infra-red radiation.[0002]Traditionally, potentially harmful ionizing radiation (for example, X-ray or y-ray) has been used to image biological tissue. This radiation propagates in the tissue on straight, ballistic tracks, i.e., scattering of the radiation is negligible. Thus, imaging is based on evaluation of the absorption levels of different tissue types. For example, in roentgenography the X-ray film contains darker and lighter spots. In more complicated systems, such as computerized tomography (CT), a cross-sectional picture of human organs is created by transmitting X-ray radiation through a section of the human body at different angles and by electronically detecting the variation in X-ray transmission. The detected intensity information is digitally stored in a computer which reconstructs the X-ray absorption of the tissue at a multiplicity of points locat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B6/00A61B5/00A61B10/00G01N21/31G01N21/47G01N21/49G01N21/64
CPCA61B5/0073A61B5/7239A61B5/1455A61B5/14551A61B5/14553A61B5/4312A61B2562/0233A61B2562/0242A61B2562/043G01N21/3151G01N21/47G01N21/4795G01N21/49G01N21/6456G01N21/6486G01N2021/1789G01N2021/3181G01N2021/6421G01N2021/6484G01N2201/0696A61B5/0091
Inventor CHANCE, BRITTON
Owner CHANCE BRITTON
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