Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions

Abstract

Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a national stage application under 35 U.S.C. §371 of PCT / US2008 / 013870 filed Oct. 2, 2008, which claims priority to U.S. Provisional Application Ser. No. 61 / 010,097 filed Jan. 4, 2008, and U.S. Provisional Application Ser. No. 61 / 137,382 filed Jul. 30, 2008, the disclosures of which are incorporated herein by this reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The invention relates generally to compositions and methods for enhancing cognitive function and particularly to compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and their use for enhancing cognitive function in animals.[0004]2. Description of Related Art[0005]Aged or aging animals frequently suffer some degree of cognitive impairment. Changes, including decline in cognitive function that progresses with age, and age-related changes in brain morphology and cerebrovascular function are commonly observe...

AI Technical Summary

Benefits of technology

[0010]It is another object of the present invention to provide methods for reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal.

[0013]One or more of these other objects are achieved using novel compositions and methods for enhancing cognitive function. Generally, the compositions comprise one or more unsaturated fatty acids and nitric oxide releasing compounds. The methods generally comprise administering the compositions in an amount effective for enhancing cognitive function, particularly to prevent, reduce and / or delay the age-related cognitive-decline, cognitive impairment, neurodegeneration conditions, stroke, and dementia in an animal.

Problems solved by technology

Aged or aging animals frequently suffer some degree of cognitive impairment.

Age-related or age-associated cognitive impairment may manifest itself in many ways, e.g., short-term memory loss, diminished capacity to learn, diminished rate of learning, diminished attention, diminished motor performance, and / or dementia, among other indicia.

However, dogs do not demonstrate every hallmark of AD, in particular, tau-containing neurofibrillar tangles (Dimakopoulos A C et al., 2002) have not been observed.

For example, they may not respond to their name or familiar commands, may get lost or confused even in familiar surroundings, may no longer greet or respond to their owners or visitors, may exhibit diminished daytime activity, may walk in circles, may shun affection, and may lose bladder or bowel control.