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Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions

a technology of unsaturated fatty acids and releasing compounds, which is applied in the direction of drug compositions, phosphorous compound active ingredients, metabolic disorders, etc., can solve the problems of reduced learning rate, cognitive impairment of aging or aging animals, and associated cognitive impairment, so as to enhance cognitive function in an animal

Inactive Publication Date: 2010-09-16
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides compositions and methods for improving cognitive function in animals. The compositions contain unsaturated fatty acids and nitric oxide releasing compounds that can prevent, reduce, or delay age-related cognitive decline, cognitive impairment, neurodegeneration, strokes, and dementia in animals. The methods involve administering the compositions to animals in an effective amount. The invention also provides articles of manufacture, kits, and packages for easy use."

Problems solved by technology

Aged or aging animals frequently suffer some degree of cognitive impairment.
Age-related or age-associated cognitive impairment may manifest itself in many ways, e.g., short-term memory loss, diminished capacity to learn, diminished rate of learning, diminished attention, diminished motor performance, and / or dementia, among other indicia.
However, dogs do not demonstrate every hallmark of AD, in particular, tau-containing neurofibrillar tangles (Dimakopoulos A C et al., 2002) have not been observed.
For example, they may not respond to their name or familiar commands, may get lost or confused even in familiar surroundings, may no longer greet or respond to their owners or visitors, may exhibit diminished daytime activity, may walk in circles, may shun affection, and may lose bladder or bowel control.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Animal and Test Groups

[0125]Cognitively-experienced beagle dogs (males and females ranging from 7.5 to 11.6 years of age) were tested. The average age of the dogs was 9.38 years. To qualify, the dogs must have had at least 6 months of previous cognitive test experience, including having been trained on the delayed non-matching-to position task (DNMP) and the oddity task.

[0126]During an initial baseline phase, all dogs were tested on a variable delay version of the DNMP task (or at 5 s if previously unable to learn the task) that provided a means of assessing visuo-spatial working memory and on a size discrimination and reversal task. Performance on these tasks was used to place the dogs into four cognitively equivalent treatment groups (twelve dogs per group): (1) 2% fish oil, 2.5% arginine, 1 to 40 times RDA B vitamins, 150 mg / kg vitamin C, 900 mg / kg vitamin E, and 0.5 mg / kg selenium (“SPB Group”); and (2) the Control Group.

Feeding and Water

[0127]Dogs had free access to water via w...

example 2

[0148]Male Charles Rivers Sprague-Dawley rats (250 g, Wilmington, Mass.) were acclimatized to animal facilities 3 days prior to surgery with a 12 hour light-dark cycle. Bilateral ovariectomy was performed 2 weeks before diet feeding began. Four weeks after the start of diet feeding, transient middle cerebral artery (tMCA) occlusion under anesthesia was performed following intraperitoneal injection of ketamine (60 mgkg) and xylazine (10 mg / kg). 15 rats per group were randomly assigned to one of four treatment groups:

[0149]Group 1—Neutered+Control Diet

[0150]Group 2—Neutered+Diet II

[0151]Group 3—Intact+Control Diet

[0152]Group 4—Intact+Diet II

[0153]The Control Diet was a standard rat diet containing 140 g / kg casein, 100 g / kg sucrose, 50 g / kg fiber, 155 g / kg dextrin, 466 g / kg corn starch, 35 g / kg standard salt mix, 40 g / kg soybean oil, 10 g / kg standard vitamin mix, 1.8 g / kg L-cystine and 2.5 g / kg choline chloride. Diet II was the Control Diet plus 2% Arginine, 2% Menhaden fish oil 4× B v...

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PUM

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Abstract

Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a national stage application under 35 U.S.C. §371 of PCT / US2008 / 013870 filed Oct. 2, 2008, which claims priority to U.S. Provisional Application Ser. No. 61 / 010,097 filed Jan. 4, 2008, and U.S. Provisional Application Ser. No. 61 / 137,382 filed Jul. 30, 2008, the disclosures of which are incorporated herein by this reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The invention relates generally to compositions and methods for enhancing cognitive function and particularly to compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and their use for enhancing cognitive function in animals.[0004]2. Description of Related Art[0005]Aged or aging animals frequently suffer some degree of cognitive impairment. Changes, including decline in cognitive function that progresses with age, and age-related changes in brain morphology and cerebrovascular function are commonly observe...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/16A61K31/202A61K31/683A61K31/522A61K31/55A61K31/4375A61K31/445A61K31/663A61K31/454A61K31/56A61K38/23A61K31/675A61P25/28A23K1/16A23K1/18A23L1/30A23D9/00
CPCA23D9/007A23K1/009A23K1/164A23K1/1846A23L1/3006A23L1/3008A23L1/3051A61K31/202A61K31/4375A61K31/445A61K31/454A61K31/522A61K31/55A61K31/56A61K31/663A61K31/675A61K31/683A61K36/16A61K45/06A61K2300/00A61K31/20A61K31/22A61K31/54A23K10/18A23K20/158A23K50/40A23L33/115A23L33/12A23L33/175A61K31/198A61K35/60A61P25/00A61P25/28A61P3/02A61P39/06A61P9/10
Inventor PAN, YUANLONG
Owner NESTEC SA
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