Methods for treating dental diseases, disorders and injuries

Abstract

Methods for preventing, reversing, ameliorating or treating dental diseases, disorders or injuries are provided. In particular, methods for preventing, reversing, ameliorating or treating dental diseases of the gingival (gums) and bone are provided. Such methods utilize novel compositions including, but not limited to, extraembryonic cytokine-secreting cells (herein referred to as ECS cells), including, but not limited to, Amnion-derived Multipotent Progenitor cells (herein referred to as AMP cells) and conditioned media derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solution or ACCS), and Physiologic Cytokine Solution (herein referred to as PCS), each alone or in combination with each other and / or other agents.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority under 35 USC §119(e) of U.S. Provisional Application No. 61 / 459,859, filed Dec. 20, 2010, the entirety of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The field of the invention is directed to methods for preventing, reversing, ameliorating or treating dental diseases, disorders and injuries. In particular, the field of the invention is directed to preventing, reversing, ameliorating or treating dental diseases, disorders or injuries of the gingival (gums) and bone. Such methods for preventing, reversing, ameliorating and treating such dental diseases, disorders and injuries utilize novel compositions including extraembryonic cytokine-secreting cells (herein referred to as ECS cells) and conditioned medium derived therefrom, including Amnion-derived Multipotent Progenitor (AMP) cells, conditioned medium derived therefrom (herein referred to as Amnion-derived Cellular Cytokine Solut...

AI Technical Summary

Benefits of technology

The patent text describes methods for treating diseases or conditions in mammals, including humans. The treatment methods can prevent the disease or condition from occurring, inhibit its development, relieve or improve the symptoms of the disease or condition, or cure it. The target audience for the treatment methods includes not only individuals already suffering from the condition or disease, but also those at risk for its development. The treatment methods can make the condition or disease better, tolerable, or even reversible.

Problems solved by technology

In the early stage of gingivitis, bacteria in plaque (a sticky, colorless film of bacteria that forms on teeth) causes the gums to become inflamed, often bleeding.

These pockets collect debris and often become infected.

Eventually the teeth are no longer anchored in place and become loose, often leading to tooth loss.

In fact, periodontitis is the leading cause of tooth loss in adults.

In addition, many illnesses can affect the gums.

Such illnesses include diseases such as cancer or HIV infection, both of which can interfere with the proper functioning of the immune system.

Smoking makes it harder for gum tissue to repair itself And of course poor oral hygiene such as not brushing and flossing on a daily basis makes it easier for gingivitis to develop.

Diabetes is not only a risk factor for gum disease, but gum disease may make diabetes worse.

This makes it harder for bacteria to collect and grow.