Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for treatment of cancer using phenothiazine

a technology of phenothiazine and composition, applied in the field of pharmaceutical composition for cancer treatment using phenothiazine, can solve problems such as cancer resistance developmen

Inactive Publication Date: 2016-05-05
NATIONAL YANG MING UNIVERSITY +1
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a new use of the drug racemic thioridazine, (S)-thioridazine, (R)-thioridazine or a pharmaceutically acceptable salt thereof in the treatment of cancer, specifically non-small-cell lung carcinoma (NSCLC). The invention also provides a pharmaceutical composition comprising racemic thioridazine, (S)-thioridazine, (R)-thioridazine or a pharmaceutically acceptable salt thereof, in combination with other anti-cancer drugs such as cisplatin, gefitinib, gemcitabine, pemetrexed or a combination thereof. The invention also provides a method for treating NSCLC by administering a therapeutically effective amount of a pharmaceutical composition comprising racemic thioridazine, (S)-thioridazine, (R)-thioridazine or a pharmaceutically acceptable salt thereof. The invention also provides a method for selecting clinical trial subjects for racemic thioridazine, (S)-thioridazine, (R)-thioridazine or a pharmaceutically acceptable salt thereof for treating NSCLC.

Problems solved by technology

Development of resistance in cancer is a major issue in cancer treatments.
This may be due to therapy-resistant tumor cell-derived disease relapse.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treatment of cancer using phenothiazine
  • Pharmaceutical composition for treatment of cancer using phenothiazine
  • Pharmaceutical composition for treatment of cancer using phenothiazine

Examples

Experimental program
Comparison scheme
Effect test

examples

Trifluoperazine

[0071]I. Materials and Methods

Cell Culture, Chemicals, and Clonogenic Assay

[0072]The NSCLC cancer cell lines, A549, H1975, CL25, CL83, CL97, CL141, and CL152 were maintained in RPMI medium. Tested cells were seeded respectively in 6 well plates with 104 cells per well for 14 days. Each well contained 10 ml RPMI medium as cultured condition for NSCLC cells. Trifluoperazine, chlorpromazine, thioridazine, triflupromazine, and promazine were purchased from Sigma and perphenazine was from Prestwick Chemical. Trifluoperazine and other tested drugs were added 24 hours after seeding of the cells. The medium and tested drugs were changed once on day 4. After the treatments, cells were washed with PBS, and the colonies were fixed with fix solution (acetic acid:methanol=1:3) and stained with 0.5% crystal violet in methanol. After removing the crystal violet carefully and rinse with tap water, the colonies were counted manually.

[0073]Side Population Analysis and Purification Usin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Electrical resistanceaaaaaaaaaa
Login to View More

Abstract

The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and / or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation-in-part application to U.S. Ser. No. 14 / 354,873 National Stage Application with 371(c) date of Apr. 28, 2014 which is an US national stage patent application of PCT Application No. PCT / CN2012 / 083698 filed on Oct. 29, 2012, entitled “PHARMACEUTICAL COMPOSITION FOR ELIMINATION OF CANCER STEM CELLS.” The present application also claims priority to provisional patent application with application No. 62 / 044,432 entitled “PHARMACEUTICAL COMPOSITION FOR ELIMINATION OF CANCER STEM CELLS—THIORIDAZINE AND THIORIDAZINE ENANTIOMER” filed on Sep. 2, 2014.FIELD OF THE INVENTION[0002]The present invention relates to a pharmaceutical composition for elimination of cancer stem cells. More specifically, the present invention relates to the use of phenothiazine for treatment of cancer.BACKGROUND OF THE INVENTION[0003]Development of resistance in cancer is a major issue in cancer treatments. Taking non-small cell lun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/5415A61K33/24A61K31/5377A61K33/243
CPCA61K31/5415A61K33/24A61K31/5377A61K31/549A61K31/519A61K31/555A61K31/7068A61P35/00A61K33/243A61K2300/00
Inventor HUANG, CHI-YINGHSIAO, JANEYANG, PAN-CHYRLEE, MENG-HUA
Owner NATIONAL YANG MING UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com