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Anti-regurgitation composition maintaining gut motility

a technology of composition and gut motility, applied in the field of medicine and human nutrition, can solve the problems of not being able to support and compensate for the pressure exerted by the gastric contents, burns or even ulcerative lesions of the esophagus, and complicating the falling asleep of the child, so as to maintain the gut motility of the child, improve the comfort of the child, and improve the effect of diet treatmen

Active Publication Date: 2017-05-04
UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is for a nutritional drink for babies and children that helps prevent stomach issues like regurgitation and reflux. The drink doesn't change the way the baby's stomach moves, so it helps avoid constipation and other stomach issues. The drink contains carob and pectins, which are cold-soluble and have different properties. This makes it easier to create the perfect blend of ingredients to help keep the baby's stomach healthy.

Problems solved by technology

It therefore cannot always support and compensate for the pressure exerted by the gastric contents.
The concerns vary in children from simple inconvenience caused by the reflux, up to pain (as the wall of the esophagus is irritated, this gives rise to burns or even to ulcerative lesions of the esophagus).
These pains are sources of tears and often complicate the falling asleep of the child.
However, these milks have drawbacks: they very often have secondary effects on gut motility.
Liquid stools are also sources of anxiety for parents.
The diarrhea may actually cause increased losses of water and electrolytes (sodium, potassium, bicarbonates) which may rapidly become a problem in young children by causing more or less severe dehydration and requiring rehydration.
Thickened infant milks with starch are rather known for causing problems of constipation.
Indeed, the longer the delay of defecation, the more the expulsion of the stools will be difficult and painful, and sometimes at the origin of anal fissures in infants or children.
This suffering, a source of discomfort when it is not a source of pain in infants and children, is also often a source of anxiety for parents who fear that this is the symptom of a serious medical problem.
This milk gives good results in terms of effect on regurgitations, but causes constipation problems in a certain number of children.
Therefore, there exist a certain number of anti-regurgitation infant milks, but these milks have undesirable secondary effects on gut motility.

Method used

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  • Anti-regurgitation composition maintaining gut motility

Examples

Experimental program
Comparison scheme
Effect test

example 1

Formulation

[0202]The formulation of milks intended for infant feeding is most often strictly restricted by legislation setting composition standards. Depending on the countries, there may be differences of appreciation notably because of local specificities in the practice of food diversification or else minor modifications of the nutritional optima resulting from locally conducted investigations or studies. Under these conditions, the present example does not intend to represent the diversity of the thickened milk formulations according to the invention.

[0203]Conventionally, in order to meet the nutritional needs of infants, infant milks comprise about 10-15% of proteins, about 25% of lipids and about 50-65% of carbohydrates as well as minerals, vitamins and optionally growth factors. Other ingredients such as one or several prebiotics and / or probiotics may moreover be added to infant milks.

[0204]A non-limiting example of a composition of the anti-regurgitation and / or anti-reflux i...

example 2

Process for Manufacturing a Pasteurized Infant Milk as a Powder Comprising i) Cold-soluble Carob and ii) at Least Two Pectins of Different Natures

[0207]The infant milk base comprising 37% of dry extract is prepared by mixing water heated beforehand to 70° C. with the different infant milk ingredients (said ingredients comprising proteins or amino acids+cold-soluble carob+weakly esterified pectins or weakly esterified and amidated pectins+highly esterified pectins+carbohydrates+minerals+plant fats+vitamins+growth factors). The carob and pectins are incorporated into the infant milk base maintained with stirring in order to obtain their complete dissolution. The whole is maintained at 70° C. with stirring in a double-walled chamber until the homogenization step. The infant milk base then undergoes dual effect homogenization at 200 / 40 bars, i.e., a first homogenization step is carried out under a pressure of 200 bars and a second homogenization step is carried out under a pressure of 4...

example 3

Comparison Between the Viscosity of a Reconstituted Milk Comprising a Milk in Powder Form According to the Invention with the Viscosity of a Conventional AR Milk Containing Starch (Novalac AR®)

[0211]An infant milk according to the invention is produced and collected as a powder according to the manufacturing process mentioned in Example 2. This milk according to the invention thus comprises 4.25% of weakly esterified pectins and weakly esterified and amidated pectins, 1% of highly esterified pectins and 0.5% of cold-soluble carob.

Method and Tools

[0212]The liquid infant milk is then prepared, by dilution of the infant milk as a powder according to the invention in hot water (at 60° C.) with 13% of dry extract. Said liquid infant milk is then cooled to 37° C.

[0213]The conventional AR milk based on starch is also prepared by diluting the powder in water (also at 37° C.) with 13% of dry extract.

[0214]The viscosities of both products are then measured by means of a Brookfield viscosimete...

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Abstract

The present invention relates to nutritional compositions intended to prevent or treat regurgitations in infants and young children without altering, or even improving, their gut motility and / or for preventing and / or treating intestinal disorders of the infant or child. The invention also concerns the process for manufacturing this composition.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. Serial No. 14 / 889,012, filed Nov. 4, 2015, which is the U.S. national stage application of International Patent Application No. PCT / EP2014 / 059312, filed May 7, 2014.FIELD OF THE INVENTION[0002]The field of the present invention is that of medicine and human nutrition, in particular infant nutrition. The invention relates to nutritional compositions intended to prevent or treat regurgitations and / or gastroesophageal reflux in infants and young children without altering, or even improving their gut motility, typically by reducing or avoiding secondary effects (constipation, liquid stools, etc.) conventionally caused by the ingestion of infant milk with an anti-regurgitation purpose. It also relates to nutritional compositions intended to prevent and / or treat intestinal disorders of the infant or child.[0003]The object of the invention is ideally to reduce, preferably suppress, regurgitation and / or ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A23L33/00A23L33/105A23L29/212A23L29/231A23L29/238
CPCA23L33/40A23L29/231A61K36/48A23L29/212A23V2002/00A23L33/105A61P1/00A61P3/02A23L29/238A61P1/04A61P43/00A23V2200/32A23V2250/507A23V2250/5072A23V2250/5118
Inventor MARGOSSIAN, JONATHAN ALBERTPRADEAU, NICOLAS
Owner UNITED PHARMA
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