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Zwitterionic hydrogels for delivery of biomolecules

a biomolecule and hydrogel technology, applied in the field of biomaterials, tissue engineering and delivery of biomolecules, can solve the problem of little report on the effect of 3-dimensionally presented zwitterions on sequestering ionic biomolecules

Inactive Publication Date: 2017-07-27
UNIV OF MASSACHUSETTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about using zwitterionic materials to hold and release proteins for guided tissue regeneration. These materials are usually thought of as being low-fouling and inactive, but this patent shows they can be used as a vehicle for delivering therapeutic proteins and promoting bone healing. This approach could reduce costs and improve safety associated with protein therapy.

Problems solved by technology

There is little report, however, on whether 3-dimensionally presented zwitterions can effectively sequester ionic biomolecules.

Method used

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  • Zwitterionic hydrogels for delivery of biomolecules
  • Zwitterionic hydrogels for delivery of biomolecules
  • Zwitterionic hydrogels for delivery of biomolecules

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Embodiment Construction

[0028]The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.

[0029]In contrast to the conventional narrow perception and categorization of zwitterionic materials as low-fouling and bioinert, the invention greatly expands the utilities of zwitterionic materials in the bioengineering and therapeutic areas. Zwitterionic networks are demonstrated as effective and versatile vehicles for engineering controlled bioactive microenvironment for biomedical applications. The invention distinguishes zwitterionic materials from the current...

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Abstract

The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.

Description

PRIORITY CLAIMS AND RELATED PATENT APPLICATIONS[0001]This application claims the benefit of priority from U.S. Provisional Application Ser. No. 62 / 022,187, filed on Jul. 8, 2014, the entire content of which is incorporated herein by reference in its entirety.GOVERNMENT RIGHTS[0002]This invention was made with Government support under grant no. AR055615 awarded by the National Institutes of Health. The Government has certain rights in the invention.TECHNICAL FIELD OF THE INVENTION[0003]The invention generally relates to biomaterials, tissue engineering and delivery of biomolecules. More particularly, the invention relates to zwitterionic polymers and methods of their applications in delivery of biomolecules and tissue engineering.BACKGROUND OF THE INVENTION[0004]Zwitterions, including phosphobetaine, sulfobetaine, and carboxybetaine, are well-known for their anti-biofouling properties as widely demonstrated on 2-dimensional (2D) surfaces. The unique zwitterionic structures, simultane...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61K38/18A61L27/18A61L27/54A61L27/52
CPCA61L27/58A61L27/54A61L27/52A61L2300/414A61K38/1875A61L2430/02A61L27/18A61K38/18A61K38/30A61L27/14A61L27/50
Inventor SONGLIU, PINGSHENG
Owner UNIV OF MASSACHUSETTS