Neuromodulation system

Abstract

Neuromodulation systems and corresponding methods for providing neuromodulation are disclosed. The neuromodulation systems can include at least one input module for inputting patient data into the neuromodulation system. The systems can further include at least one model calculation and building module for building a patient model, the patient model describing the anatomy and/or physiology and/or pathophysiology and the real and/or simulated reaction of the patient on a provided and/or simulated neuromodulation. The systems can further include at least one computation means for using the patient model (M) and calculating the impact of the provided and/or simulated neuromodulation.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]The present application claims priority to European Patent Application No. 19211698.6 filed on Nov. 27, 2019. The entire contents of the above-listed application is hereby incorporated by reference for all purposes.TECHNICAL FIELD[0002]Disclosed embodiments relate to a neuromodulation system, in particular a neuromodulation system for restoring motor function and / or autonomic function in a patient suffering from impaired motor and / or autonomic function after spinal cord injury (SCI) or neurologic disease.BACKGROUND AND SUMMARY[0003]Decades of research in physiology have demonstrated that the mammalian spinal cord embeds sensorimotor circuits that produce movement primitives. These circuits process sensory information arising from the moving limbs and descending inputs originating from various brain regions in order to produce adaptive motor behaviors.[0004]SCI interrupts the communication between the spinal cord and supraspinal centers, de...

AI Technical Summary

Benefits of technology

[0032]In some embodiments, the system may further comprise an output device, such as a display unit, for outputting at least one of pre-operative planning data, intra-operative planning data and / or post-operative planning data. In some embodiments, the output device may provide visual information concerning or representing the pre-operative planning data, intra-operative planning data and / or post-operative planning data. In some embodiments, such visual information can provide a user (e.g. a surgeon and / or therapist) with anatomical and / or physiological and / or pathophysiological data concerning a patient, which can support selection of optimal neuromodulation therapy configurations.

[0033]In some embodiments, pre-operative planning data may include at least one of surgical incision placement, optimal electrode placement, eligibility of the patient, in-silico assessment of benefit for decision making. In some embodiments, this has the advantage that optimal stimulation, specifically adapted to a patient's needs is enabled and / or surgery procedures are kept as short as possible, without harming the patient by unnecessary trial-and error procedures.

[0034]The intra-operative planning data may include at least one intra-operative imaging data such as MRI, CT, Fluoroimaging, X-Ray, IR, video, laser measuring, optical visualization and imaging, real-time registration, navigation system imaging, EEG, ECG, EMG, mechanical feedback and the like. This has the advantage that the patient's anatomy including any injured tissue and / or anatomical peculiarities and / or physiology and / or pathophysiology is revealed, and the planned therapy can be adapted specifically to the patient's needs.

[0035]In some embodiments, the post-operative planning data may include at least one recommend optimum electrode configuration, stimulation waveforms, timings schedule for neuromodulation events and the like. This may enable that the neuromodulation and / or neuromodulation therapy may be adapted to specific tasks and, at the same time, to the patient's needs. Overall, this may enable optimal neuromodulation outcome.

Problems solved by technology

Currently these parameters can only be determined by time-consuming, invasive, and often unsuccessful trial and error procedures.

Such testing can be expensive, time-consuming, ineffective, and hazardous.

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