The present invention relates to dental instruments including dental burs, dental discs, tapes, endodontic files, surgical drills and taps, scalers, mirrors, intra-oral light sources, handpieces, perioscopes, covers for dental instruments and other tools having anti-microbial and/or medicament coatings which may be in a substantially permanent covalent manner or in a substantially non-permanent manner. The anti-microbial coating may be made from a variety of anti-microbial substances and other appropriate constituents to promote its fixing to the surface of the dental instrument and to promote its anti-microbial activity either during use or during storage. The substrate of the instruments may also include sources of anti-microbial agents, either by embedding, filling or mixing into the substrate.