59results about "Anhydrosugars" patented technology

The disclosed preparation method for acetylized glucal comprises: preparing the D-acetylized glucose catalyzed by acids (HClO4, H2SO4, ZnCl2, AlCl3, p-toluenesulfonic acid and methanesulfonic acid); without separation or purification, leading directly the product into HBr or equivalent (such as PBr3 and water) to obtain and then recrystallize the coarse 1-bromoacetyl glucose with one of ethyl ether, propyl ether and isopropyl ether; adding Zn, ZnCl2, methanol and Co-ion catalyst to prepare the coarse target; recrystallizing with alcohol for the refined product. This invention saves step and reduces cost.

Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein alpha-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.

This invention concerns a process for recovering and purifying dianhydro sugar alcohols from a vapor stream comprising dianhydro sugar alcohols, such as isosorbide, and water vapor.

The invention discloses a method for preparing levoglucosenone, which comprises the following steps: enabling biomass to be in contact with acid, wherein the acid is solid acid, sulfuric acid or a mixture of sulfuric acid and other liquid acid; and carrying out pyrolysis at 200-380 DEG C, collecting the liquid, and separating out levoglucosenone. The biomass material and the acid catalyst in the method are common, easy to acquire and low in cost; the pyrolysis temperature is low, and the product yield can be improved; and the corrosion and pollution caused by the acid can be effectively reduced. Thus, the method for preparing levoglucosenone is economic and effective.

A method for alkylation of an anhydrosugar compound in which a dialkyl carbonate is reacted with an anhydrosugar compound in the presence of a solid phase basic catalyst. A typical anhydrosugar compound is anhydrosugar alcohol, a dianhydromonoether and mixtures thereof. The reaction step uses zeolyte as the solid phase basic catalyst. The zeolite catalyst is typically a zeolite having ammonium groups. The reaction is carried out at a temperature below 240° C. and the reaction time is 2 hours or less.

The invention belongs to the field of biomass energy utilization and particularly relates to a method for preparing levoglucose ketone through catalyzing and pyrolyzing cellulose by utilizing solid phosphoric acid. The method comprises the steps of taking the solid phosphoric acid as catalyst, mechanically mixing with the cellulose, carrying out fast pyrolysis at a temperature of 280-450 DEG C under an oxygen-free condition, condensing the pyrolysis gas and obtaining a liquid product rich in the levoglucose ketone. In the liquid product obtained through catalyzing and pyrolyzing the cellulose by utilizing the solid phosphoric acid, the yield and the purity of the levoglucose ketone are both high; in addition, the solid phosphoric acid catalyst is stable in performance and can be repeatedly and cyclically utilized.

The invention belongs to the field of utilization of biomass energy, and in particular relates to a method for preparing levoglucosenone through biomass catalytic pyrolysis. The method comprises the following steps: by taking biomass base phosphoric acid activated carbon as a catalyst, performing mechanical mixing on the catalyst with biomasses, performing flash pyrolysis at 250-470 DEG C under an inert anaerobic condition, and condensing a pyrolysis gas, thereby obtaining a liquid product rich in levoglucosenone. In pyrolysis products of the biomasses subjected to catalytic pyrolysis of the biomass base phosphoric acid activated carbon, the yield and the purity of levoglucosenone are both relatively high; in addition, a mixture of solid coke generated through pyrolysis and the catalyst can be used as a carbon source which is continuously adopted to prepare activated carbon; due to adoption of the biomass base phosphoric acid activated carbon which is low in price and can be recycled, the production cost and the pollution can be effectively reduced, and the method is an economic and effective method for preparing the levoglucosenone.

The present invention relates to a method for preparing 3,6-anhydro-L-galactose, and use thereof. More specifically, 3,6-anhydro-L-galactose, which is a monosaccharide constituting agar, is produced in a high yield through chemical and enzymatic methods, and the physiological activities thereof such as whitening, moisturizing, antioxidant, anti-inflammatory activities and the like are displayed, thereby enabling industrial use thereof.

The invention discloses a method for preparing laevoglucose ketone and special reaction equipment thereof. The reaction equipment comprises a fluidized bed pyrolysis reactor(4), wherein an opening on the bottom part of the side wall of the fluidized bed pyrolysis reactor(4) is connected with a feeder(2) by a tube, an opening at the top end of the reactor(4) is connected with a separator(6) by a tube, an opening at the top end of the separator(6) is connected with an opening at the top end of a catalytic reactor(7) by a tube, an opening on the bottom part of the catalytic reactor(7) is connected with a condenser(8) by a tube, and the bottom part of the condenser is provided with a liquid outlet. The preparation method comprises the following steps of: in the reaction equipment, feeding cellulose or biomass materials to the pyrolysis reactor for pyrolysis, performing gas-solid separation by the separator, performing a catalytic cracking reaction of the pyrolyzed gas generated in the pyrolysis reaction in a reactor filled with a catalyst of chromic chloride, and after reaction, condensing the gas by the condenser to obtain the finished product. Because the celluloses or biomass are used as raw materials and the yields of the organic liquid products all reach over 15 percent, wherein the laevoglucose ketone content reaches over 30 percent.

The invention belongs to the field of biomass energy use and particularly relates to a levoglucosenone preparation method. The levoglucosenone preparation method includes: mechanically mixing char sulfonic acid or magnetic char sulfonic acid serving as a catalyst with biomass raw materials, performing fast pyrolysis at the temperature of 280-450 DEG C under the anaerobic condition, and condensing pyrolysis gas so that a liquid product rich in levoglucosenone can be obtained. In the liquid product prepared by the method, both yield and purity of the levoglucosenone are high; and the catalyst is stable in performance, can be directly separated and recovered from solid residues mechanically or by the aid of a magnetic field and is reusable.

The invention relates to a green preparation method of levoglucosone having a high added value. The green preparation method comprises the following steps that 1, cellulose or wood fiber-like biomass contacts with a phosphate, the phosphate is a monophosphate or a phosphate-containing mixture, and a mass ratio of the phosphate to the wood fiber-like biomass mixed mechanically is in a range of 0.01: 1-100: 1; and 2, under the oxygen-free condition, the mixture obtained by the step 1 is subjected to pyrolysis at a temperature of 200-700 DEG C for more than 0.0001s; the pyrolysis product is condensated; and the condensate is collected; and levoglucosone is separated from the condensate. The wood fiber raw material is common and can be obtained easily. The phosphate has a low price, good stability and a low pyrolysis temperature. Levoglucosone has high selectivity. Through use of the phosphate which has a low price and can be recycled, a production cost, acid corrosion and acid pollution are reduced. The green preparation method is a green, economic and effective method for preparing levoglucosone.

The invention belongs to the field of utilization of biomass energy, and particularly relates to a titanium-based magnetic solid super-acid catalyst and a preparation method thereof and a method for preparing laevoglucose ketone by means of catalytic pyrolysis of cellulose or biomass through the catalyst. The titanium-based magnetic solid super-acid catalyst is a composite catalyst utilizing SO42- / TiO2 which is accelerated by sulfate radical as a catalytic active component and utilizing Fe3O4 as a magnetic matrix. The preparation method includes steps of mechanical mixing of cellulose or biomass, quick pyrolysis on anaerobic condition at the temperature of 280 DEG C to 450 DEG C and condensation of pyrolysis gas, and finally liquid product rich in laevoglucose ketone can be obtained. The laevoglucose ketone in the liquid product which is generated by utilizing the magnetic solid super acid catalyst to realize pyrolysis of cellulose or biomass is high in productivity and purity. In addition, the catalyst can be separated and recycled from solid residues by the aid of an external magnetic field directly.

Belonging to the utilization field of biomass energies, the invention specifically relates to a method for preparing levoglucosenone by utilizing a magnetic solid phosphoric acid catalyst for catalytic pyrolysis of cellulose / biomasses. The method comprises: taking magnetic solid phosphoric acid as the catalyst, which is then mechanically mixed with cellulose / biomasses, then conducting rapid pyrolysis under an anaerobic condition at a temperature of 280-450DEG C, and carrying out condensation on pyrolysis gas, thus obtaining a liquid product rich in levoglucosenone. In the liquid product of magnetic solid phosphoric acid catalyzed pyrolysis of cellulose, the yield and purity of levoglucosenone are both high. In addition, being stable in performance, the catalyst can be separated and recovered from solid residue by directly utilizing an external magnetic field and can be recycled repeatedly.

The invention relates to a method for preparing high-additional-value chemicals by different pH acid-alkali pretreatment of biomass and one-step cracking. The method comprises the following steps: pulverizing the biomass into powder; pretreating the powder by using different pH acid-alkali treatment solutions; after pretreating, carrying out rotary evaporation and vacuum drying to obtain the treated biomass powder; loading the treated biomass powder and an HZSM-5 molecular sieve in a reaction tube; and carrying out thermal cracking reaction in the nitrogen atmosphere at the heating speed of 50-80 DEG C / min to obtain the chemicals. The method is easy to operate and low in requirements of equipment; and the used biomass is agricultural wastes such as sugar cane bagasse and corn cobs, the high-additional-value chemicals such as 2,3-dihydrobenzofuran, 4-ethyl-guaiacol, levoglucosenone, 1-hydroxyl-2-butanone and 1,2-cyclopentanedione are produced by the agricultural wastes, in the aspect of raw materials, the agricultural wastes are cycled, environmental pollution is reduced, and the method has high economic value and social value and has important significance.

The invention relates to the field of preparation of organic matters, and in particular relates to a method for preparing levoglucose ketone by catalytic pyrolysis of a biomass. The method comprises the following steps: by taking zinc chloride sludge carbon as a catalyst, carrying out pyrolysis at 270-400 DEG C under an anaerobic condition by mixing the catalyst with the biomass mechanically; and collecting a condensed liquid to obtain a liquid product rich in levoglucose ketone. According to the method provided by the invention, the catalyst and the biomass raw materials are low in price, easily available and free from corrosion to pyrolysis equipment, so that the production cost is relatively lower. In addition, the zinc chloride sludge catalyst is stable in performance and can be recycled for times.

The invention discloses a preparation method of levoglucosenone. The preparation method comprises the following steps of firstly, dissolving phosphoric acid in water to form a phosphoric acid solution; adding cellulose or cellulose-contained biomass, mixing and soaking; filtering the soaked cellulose or cellulose-contained biomass, pressing and extruding or centrifuging, and performing pyrolysis pretreatment on the treated matter, so as to obtain a dewatered intermediate product; cooling the obtained dewatered intermediate product to room temperature, cooling, putting into a sodium hydroxide or potassium hydroxide water solution, and fully mixing and soaking; filtering the mixed and soaked product, pressing and extruding or centrifuging, performing non-oxygen pyrolysis on the treated product, and collecting condensate in the pyrolysis process, so as to obtain a pyrolysate containing the levoglucosenone. The preparation method of the levoglucosenone has the advantages that by adopting two-step reaction, the yield rate is greatly increased and reaches about 40%; compared with the prior art, the cost is greatly reduced; by adopting the technical scheme, the large application prospect is realized.

The invention belongs to the field of biomass energy utilization and particularly relates to a preparation method of a pyrolytic carbon-modified catalyst, and a method for preparing levorodextrone by catalyzing pyrolytic cellulose by using the catalyst. The pyrolytic carbon-modified catalyst is a composite catalyst formed by activating activated carbon generated by pyrolyzation of the cellulose as a carrier by using a sulfuric acid; and the pyrolytic carbon-modified catalyst and the cellulose are quickly catalyzed and pyrolyzed at 300-400 DEG C in an oxygen-free environment in a fixed bed reactor to obtain a liquid product containing levorodextrone. Levorodextrone is high in yield and high in purity. In addition, the catalyst is cheap and easy to prepare, does not need to be separated from a pyrolytic residue of the cellulose, and can be further processed for further use.

Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

The invention discloses a preparation method of a catalyst for producing levoglucosenone. The preparation method comprises the following steps: S1, crushing a biomass raw material, fully mixing the crushed biomass raw material with a KOH activator according to a mass ratio of 4:1 to 1:4, adding the obtained mixture into a reactor, and carrying out a pyrolysis reaction under the protection of nitrogen to obtain biochar; S2, mixing the biochar obtained in S1 with concentrated sulfuric acid, sulfonating the biochar in a hydrothermal kettle, cooling the hydrothermal kettle, washing the obtained reaction product with deionized water to be neutral, and drying the washed reaction product in a drying oven to obtain sulfonated carbon; and S3, impregnating the sulfonated carbon to load metal ions, and performing washing and drying to obtain the metal sulfonated carbon catalyst. The invention also discloses the catalyst for producing levoglucosenone. The catalyst loaded with metal ions can effectively promote the conversion of the biomass raw material to a dehydration intermediate in the pyrolysis process, and also enhances the activity of strong acidic sites of the sulfonated carbon in orderto dehydrate the intermediate into the levoglucosenone.

The present invention relates to a process for modifying catalysts via the deposition of carbon containing residues in the presence of one or more solvents, where the gas phase over the catalyst treatment solution during the treatment is air or an inert gas, and / or the liquid phase contains a templating agent and / or base. The modified catalyst can be used for stereo-, chemo- and regio selective transformations of organic compounds.

The invention relates to a method for preparing 2-nitrine-1, 6-D-anhydro-sugars, which is realized by the following steps: (1). absolute acetylation D-glucose or L-glucose (1) and phenol are reacted to prepare phthalic anhydride (2); (2). acetyl is removed under the condition of alkalescence and 1, 6-D-anhydro-sugars (3) are prepared; (3). Ts is used for selectively protecting, activating and preparing 2-4-hydroxide radical (4) by using steric clash in a lower temperature; (4). 3-4-epoxy compounds (5) is selectively prepared; (5) benzoic alcohol opening epoxy is used for preparing a compound (6); (6). a 2-3-epoxy compound (7) are prepared under the condition of alkalescence; (7) nitrine opening epoxy is used for preparing the compond; (8) phenmethyl protective hydroxide radical is used for preparing final products(9). The method has the beneficial effects of avoiding virulent organo-tin compound to be used and being suitable for industrial production.

The invention relates to new polysulfated glycosides of formula (I), the salts thereof formed with alkali metals or alkaline-earth metals, as well as the pharmaceutical compositions containing these compounds as active ingredients. Furthermore the invention provides a method of preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders of the airways of mammals—including asthma and asthma-related pathologies.

Dianhydrohexitol pellets, whose fluidity is preserved even after lengthy storage, include between 90% and 100%, preferably between 95% and 100%, and more preferentially between 97% and 100% of dianhydrohexitols by weight, on a dry weight basis, and have the particularity of not being subject to caking. A process for preparing the dianhydrohexitol pellets is also described.

The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.

Dianhydrohexitol pellets, whose fluidity is preserved even after lengthy storage, include between 90% and 100%, preferably between 95% and 100%, and more preferentially between 97% and 100% of dianhydrohexitols by weight, on a dry weight basis, and have the particularity of not being subject to caking. A process for preparing the dianhydrohexitol pellets is also described.

The invention discloses a method for preparing levoglucosenone. The method comprises the following steps: grinding and mixing waste strongly acidic macroporous resin Amberlyst-15 and cellulose powder according to a mass ratio of (0.1-1): 1, and carrying out co-pyrolysis in an oxygen-free environment at 250-450 DEG C to prepare the levoglucosenone. According to the method, the waste strongly acidic macroporous resin Amberlyst-15 and the cellulose are subjected to co-pyrolysis treatment, so that the selective conversion of the cellulose to levoglucosenone can be promoted, and the green resource utilization and treatment of the waste resin high polymer can be realized. The method is simple and easy to implement, and can be further popularized and applied to pyrolysis conversion of other wood fiber biomass resources and green resource reutilization and co-treatment of waste resin.

The invention belongs to the field of utilization of biomass energy, and in particular relates to a method for preparing L-glucosone by catalytic pyrolysis of biomass. The invention uses biomass-based phosphoric acid-activated activated carbon as a catalyst, and through mechanical mixing with biomass, rapid pyrolysis is carried out at 250-470°C under inert and oxygen-free conditions, and rich L-glucose can be obtained after condensing the pyrolysis gas The liquid product of ketones. Biomass-based phosphoric acid activated activated carbon catalytic pyrolysis of biomass pyrolysis products, the yield and purity of glucosone are high; in addition, the mixture of solid coke and catalyst generated by pyrolysis can be used as a carbon source to continue to prepare activated carbon ; By using low-cost and reusable biomass-based phosphoric acid-activated activated carbon, the production cost and pollution can be effectively reduced, and it is an economical and effective method for preparing L-glucosone.

A modifier characterized by containing as the active ingredient a compound represented by the formula (I) (wherein X is OH, OSO3H, or OCH3 and R is a substituent excluding OH). The modifier is applied to a substance having reactivity with the compound.