The present invention discloses an intelligent cooling device for a transformer substation. The intelligent cooling device comprises a distribution box body, a square block is fixedly installed at thetop of the distribution box body, a square inserting groove is formed in the right side of the square block, a threaded groove is formed in the bottom of the inner wall of the square inserting groove, and a fixing mechanism is arranged at the top of the square block; and a square inserting block is inserted into the square inserting groove. Through cooperative use of the power distribution box body, the square block, the square inserting groove, the fixing mechanism, the fixing rod, a pushing handle, a threaded rod, the square inserting block, a protection block, a square through hole, a square fixing block, a placement groove, a positioning mechanism, an extrusion spring, a square stop block, a positioning block, variable-frequency cooling equipment, a threaded groove, a thermometer, a limiting groove and a limiting block, a circular matching hole and a circular through hole, the problem that the existing cooling effect is poor is solved, and the intelligent cooling device has the advantage of being good in cooling effect and is suitable for a transformer substation.