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Medicinal composition with heat-clearing, fire-draining and detoxification function

A technology for detoxification effect and composition, which is applied in the field of pharmaceutical compositions with heat-clearing, fire-purging and detoxifying effects, can solve problems such as failure to fully utilize and exert free anthraquinone of rhubarb, and achieve easy product quality, clear active ingredients, Overcome the effects of low bioavailability

Inactive Publication Date: 2008-02-27
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common feature of these drugs is that they all fail to fully utilize and exert the antibacterial and antiviral effects of rhubarb free anthraquinones.

Method used

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  • Medicinal composition with heat-clearing, fire-draining and detoxification function
  • Medicinal composition with heat-clearing, fire-draining and detoxification function
  • Medicinal composition with heat-clearing, fire-draining and detoxification function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of rhubarb free anthraquinone:

[0021] Take 5 kg of rhubarb medicinal material and grind it, add 6 times the amount of 70% ethanol, heat and reflux for extraction 3 times, each time for 1 hour, filter, combine the extracts, recover the solvent, and obtain an extract equivalent to about 3 g rhubarb / ml. Add 150ml of concentrated hydrochloric acid under stirring, hydrolyze at 60°C for 5 hours, cool, filter, wash with water until pH 3-5, and precipitate. The precipitate was pulverized, added to 70% ethanol solution containing 3% sodium hydroxide, fully stirred to dissolve, and filtered to obtain an alkali-alcohol solution. Add hydrochloric acid to acidify to pH 2-3, produce precipitate, stand overnight, filter, wash with 50% ethanol, dry, and obtain rhubarb free anthraquinone. According to detection and analysis, its main components are anthraquinone derivatives such as rhein, emodin, chrysophanol, emodin methyl ether and aloe-emodin, and the total content of ...

Embodiment 2

[0024] Preparation of rhubarb free anthraquinone:

[0025] After taking 5 kg of rhubarb medicinal material and slicing it, add 10 times the amount of water and decoct twice for 0.5 hours each time, filter, combine the extracts, and concentrate to obtain an extract equivalent to about 2 g rhubarb / ml. Add 200ml of concentrated sulfuric acid while stirring, hydrolyze at 80°C for 4 hours, cool, filter, wash with water until pH 3-5, and precipitate. The precipitate was pulverized, added to a 50% ethanol solution containing 2% sodium hydroxide, fully stirred to dissolve, and filtered to obtain an alkali-alcohol solution. Add hydrochloric acid to acidify to pH 1-2, produce precipitate, stand overnight, filter, wash with 50% ethanol, dry, and obtain rhubarb free anthraquinone. The composition analysis and the determination of the total free anthraquinone content were carried out according to the above method. The main components were anthraquinone derivatives such as rhein, emodin, chr...

Embodiment 3

[0028] The Scutellaria baicalin extract was prepared according to the preparation method of the Scutellaria baicalensis extract under the item "Sanhuang Tablet" [Preparation Method] on page 328 of the 2005 edition of the Pharmacopoeia of the People's Republic of China. The content of baicalin was determined to be 72.5% by high performance liquid chromatography.

[0029] Take 20g of rhubarb free anthraquinone, 20g of berberine hydrochloride and 100g of baicalin baicalin extract, add appropriate amount of pharmaceutical excipients, mix well, dry granulate, pack 1000 capsules, which is the capsule dosage form drug .

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Abstract

The invention provides a pharmaceutical composition for alleviating fever, purging the intense heat and detoxicating, which comprises (by weight parts) free anthraquinone from rheum officinale 0.5-5 parts, berberine or its hydrochlorate salt 1 part, baikal skullcap glycoside 2-5 parts, and pharmaceutically acceptable auxiliary compositions. The composition can be prepared into the dosage forms of oral administration and / or external formulations.

Description

technical field [0001] The invention relates to a medicinal composition which can be derived from natural medicinal raw materials and has functions of clearing away heat, purging fire and detoxifying. Background technique [0002] Rhubarb is a commonly used traditional Chinese medicinal material with a wide range of uses. It has the functions of purging heat and dredging intestines, cooling blood and detoxifying, removing blood stasis and dredging menstruation. Analgesic, anti-tumor, improve renal insufficiency and other pharmacological effects. The main active ingredient of rhubarb is combined anthraquinone and a small amount of free anthraquinone in the form of glycosides. The combined anthraquinone mainly includes chrysophanol-1-glucoside, chrysophanol-8-O-β-D-glucoside, rhubarb Emodin-1-O-β-D-glucoside, Emodin-8-O-β-D-glucoside, Emodin-8-O-β-D-glucoside, Aloe-Emodin-8-O- β-D-glucoside, rhein-8-O-β-D-glucoside, sennoside (sennoside) A, B, C, D, E, F, etc.; free anthraqu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/04A61P31/12A61P29/00A61P13/12A61P1/10A61P35/00A61K31/122A61K31/4375
Inventor 易进海陈燕黄志芳刘玉红刘云华
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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