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Recombination human granul ocyte-macrophage colong stimulating factor ges and its preparation method

A technology of colony-stimulating factor and macrophage, which is applied in the field of preparation of the gel, can solve the problems of few effective drugs, limited clinical application, short half-life, etc., and achieve the effect of promoting healing, alleviating the pain of medication, and low recurrence rate

Inactive Publication Date: 2008-08-06
浙江优诺金生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, rhGM-CSF has a short half-life in the body, less effective drugs can reach the wound after passing through the systemic circulation, and it brings a lot of inconvenience to patients, which limits its clinical application.

Method used

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  • Recombination human granul ocyte-macrophage colong stimulating factor ges and its preparation method
  • Recombination human granul ocyte-macrophage colong stimulating factor ges and its preparation method
  • Recombination human granul ocyte-macrophage colong stimulating factor ges and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Take 1 g of methylcellulose, 2 g of glycerin, 1 g of ethyl p-hydroxybenzoate, and 1 g of chondroitin sulfate, add dissolved water to 100 g, mix well, and then autoclave at 0.1 MPa and 121 ° C for 15 min, cool to room temperature, and make matrix sections. 5 g of human serum albumin and 100 μg of rhGM-CSF were added to the matrix, and at the same time, the mixture was stirred slowly to make rhGM-CSF gel.

Embodiment 2

[0048] Example 2: Get 2g of sodium carboxymethylcellulose, 5g of propylene glycol, 3g of methyl p-hydroxybenzoate, 2g of sodium lauryl sulfate, add dissolved water to 100g, mix well, and then under 0.1MPa, 121°C , autoclave for 25 min, and cool to room temperature to make matrix sections. 1 g of human serum albumin and 300 μg of rhGM-CSF were added to the matrix, and at the same time, the mixture was stirred slowly to make rhGM-CSF gel.

Embodiment 3

[0049] Example 3: Take 5g of polyethylene glycol, 5g of propylene glycol, 3g of sorbic acid, and 3g of Tween, add dissolved water to 100g, mix well, then sterilize under high pressure at 0.1MPa and 121°C for 15 minutes, and cool to room temperature , to make the matrix part. 5 g of human serum albumin and 300 μg of rhGM-CSF were added to the matrix, while stirring slowly and evenly, to prepare rhGM-CSF gel.

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Abstract

A recombinant human granulocyte-macrophage colony stimulating factor gels for treating burn, scald and ulcer is prepared through proportionally mixing thickening agent wetting agent, antiseptic, stabilizer and water together, stirring, high-pressure sterilizing at 100-126 deg.C under 0.08-0.15 MPa for 15-30 min, natural cooling, and adding recombinant human granulocyte-macrophage colony stimulating factor protein solution and human serum albumin solution. Its advantages are high curative effect, easily cleaning, no irritation to skin and no toxic by-effect.

Description

technical field [0001] The invention relates to a gel for treating wound damage caused by burns, scalds and ulcers. Specifically, recombinant human granulocyte-macrophage colony-stimulating factor (hereinafter referred to as rhGM-CSF) is mixed with an appropriate matrix to make it for external use. Gel, the present invention also relates to the preparation method of the gel. Background technique [0002] rhGM-CSF is an acidic protein produced and secreted by activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts. rhGM-CSF has the effect of producing leukocytes and is a cell growth factor necessary for regulating hematopoietic and leukocyte functions. It can comprehensively improve the pathological characteristics of chronic ulcers, promote wound repair, and enhance the bactericidal ability of granulocytes and macrophages. Widely involved in hematopoiesis, immunity and anti-infection processes, and plays an important role in wound healing. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/22A61K9/00A61P17/02
Inventor 李树奇
Owner 浙江优诺金生物工程有限公司
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