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Ophthalmic pharmaceutical composition for resisting fungus

A technology of antifungal drugs and compositions, applied in the field of medical preparations, can solve problems such as large toxic side effects, large dosage of drugs, drug resistance of bacteria and the like

Inactive Publication Date: 2008-09-17
河南省眼科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that if the dosage of unilateral use is large, it will produce relatively large toxic and side effects, and long-term use will easily cause the bacteria to develop drug resistance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Take 1 g of econazole, add 300 ml of water for injection, suspend it by ultrasonication, the diameter of the particles meets the requirements of eye drop suspension, and sterilize with circulating steam at 100°C; then, under aseptic conditions, inject with water for injection Dissolve 10 grams of amphotericin B powder in 600 ml to make a solution, mix the amphotericin B solution with econazole suspension, add water for injection to make up to 1000 ml, stir evenly, and finally in aseptic condition Just download it.

[0011] The econazole and amphotericin B can also be mixed to make an antifungal pharmaceutical composition by other techniques for making eye drops.

Embodiment 2

[0012] Example 2: The antifungal pharmaceutical composition is prepared by mixing 10 grams of econazole and 1 gram of amphotericin B using the existing technology for making eye drops.

Embodiment 3

[0013] Example 3: The antifungal pharmaceutical composition is prepared by mixing 1 gram of econazole and 9 grams of amphotericin B with the existing technology for making eye drops.

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PUM

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Abstract

The invention discloses a pharmaceutical antifungal composition for treating ophthalmic diseases, which comprises Econazole and amphotericin B by the weight ratio of 1:10-10:1. The MIC of the pharmaceutical composition to fusarium is 1mug / ml and 2mug / ml to Aspergillus.

Description

technical field [0001] The invention belongs to medical preparations, in particular to an antifungal pharmaceutical composition used in ophthalmology. Background technique [0002] Ocular fungal infection is currently a refractory disease in ophthalmology, and there is no ideal antifungal drug in clinical practice. Studies have shown that most eye fungal infections are caused by Fusarium and Aspergillus. Among the existing patented medicines at home and abroad, there is no compound eye drops for these two fungi. Experiments have proved that when used alone, econazole and amphotericin B have a certain inhibitory effect on Fusarium and Aspergillus, and the minimum inhibitory concentration (MIC) against Fusarium: econazole is 16 μg / ml Amphotericin B is 4 μg / ml; minimum inhibitory concentration (MIC) against Aspergillus: econazole is 4 μg / ml; amphotericin B is 4 μg / ml. It can be seen that the large dosage of unilateral use will produce greater toxic and side effects, and long-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/10A61P27/02A61K31/4164
Inventor 王丽娅张俊杰高长凤
Owner 河南省眼科研究所