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Medicinal composition containing safflower total flavone and its preparation process and usage

A technology of safflower total flavonoids and composition, applied in the field of medicine, can solve the problems of insufficient therapeutic effect of cardiovascular and cerebrovascular diseases, no development of clinical application, complex and time-consuming treatment, etc., to maintain nerve stress ability, improve microcirculation, and produce finished products rate-enhancing effect

Active Publication Date: 2008-12-10
通化谷红制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in terms of curative effect, the "safflower patent" still has insufficient therapeutic effect on cardiovascular and cerebrovascular diseases; there are still clinical applications that have not been developed; in terms of technology, the "safflower patent" uses alcohol precipitation to treat the safflower extract , there are many impurities in the product, the processing is complicated and time-consuming, and the product yield is low

Method used

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  • Medicinal composition containing safflower total flavone and its preparation process and usage
  • Medicinal composition containing safflower total flavone and its preparation process and usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1-pharmaceutical composition

[0026] Add 30 times the volume of 15% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.25-1.30, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of refrigeration is controlled between 0 and 4°C. Proportioning is carried out according to the weight of acetylglutamine being 15 times of total flavonoids of safflower.

Embodiment 2

[0027] The preparation of embodiment 2-pharmaceutical composition

[0028]Add 50 times the volume of 30% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.20-1.50, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of the refrigeration is controlled between 0 and 4°C. According to the weight of acetylglutamine being 18 times of the total flavonoids of safflower, it is prepared.

Embodiment 3

[0029] The preparation of embodiment 3-pharmaceutical composition

[0030] Add 200 times the volume of 45% ethanol solvent to the original medicinal material of safflower, use a microwave with a frequency of 1100 MHz and a power of 12000 watts, extract 5 times under the condition of 70 ° C, 50 minutes each time, combine the extracts, and use NaOH or Adjust the pH to 7-8 with hydrochloric acid, add a chitosan solution with a concentration of 0.5%, stir, let stand for 1-2 hours, filter, and dry the filtrate under reduced pressure at 65°C to an extract with a specific gravity of 1.25-1.30, namely For the total flavonoids of safflower. The total flavonoids are stored under refrigeration, and the temperature of refrigeration is controlled between 0 and 4°C. According to the weight of acetylglutamine being 18 times of the total flavonoids of safflower, it is prepared.

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses a pharmaceutical composition containing safflower total flavonoids for treating cardiovascular and cerebrovascular diseases, which contains a certain proportion of safflower total flavonoids and acetylglutamine. The pharmaceutical composition of the present invention The compound preparation composed of total flavonoids of safflower and acetylglutamine, through the mutual complementation and synergistic effect of the two on the body, can fully play the role of promoting blood circulation and removing blood stasis, improving brain metabolism and brain function, and can be used as a preparation for the treatment of occlusive cerebrovascular diseases , hepatic coma, hemiplegia, neurosurgery and other diseases caused by coma, paralysis, mental decline, memory impairment and other drug applications; it can also be used for the preparation of drugs for the treatment of coronary heart disease, vasculitis and epilepsy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition composed of safflower total flavonoids and acetylglutamine, safflower extracting effective parts and acetylglutamine, its preparation method and its application in the treatment of occlusive cerebrovascular Diseases, hepatic coma, hemiplegia, neurosurgery and other coma, paralysis and mental retardation, memory impairment, epilepsy and other diseases. Background technique [0002] Safflower is the dry flower of safflower (Carthamus tinctorins L), which is warm in nature and pungent in taste. Can promote blood circulation and stimulate menstruation, dissipate blood stasis and relieve pain. For irregular menstruation, dysmenorrhea and amenorrhea bruises. It has a certain curative effect on coronary heart disease, vascular embolism disease, and infectious hepatitis. Safflower contains Flavonols, Chalcones, Alkane diols, Serotonin derivativ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/16A61K36/286A61K9/16A61K9/19A61K9/20A61K9/48A61P1/16A61P9/10A61P25/00
Inventor 张玉梅
Owner 通化谷红制药有限公司
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