Unlock instant, AI-driven research and patent intelligence for your innovation.

Polymorphism detection method and use of schizophrenia relative gene MPZI1

A single nucleotide polymorphism, schizophrenia technology, applied in the gene field of biotechnology, can solve the problem that there is no correlation between MPZ11 gene polymorphism sites and schizophrenia, and there is no report that MPZ11 gene is related to schizophrenia. research reports, etc.

Inactive Publication Date: 2009-04-29
苏州市长三角系统生物交叉科学研究院有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching the domestic and foreign literature of the prior art, there has been no research report on the association between MPZ11 gene and schizophrenia, and there is no report on the correlation between MPZ11 gene polymorphism site and schizophrenia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polymorphism detection method and use of schizophrenia relative gene MPZI1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0105] Below in conjunction with specific embodiment, to further illustrate the present invention. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0106] In this embodiment, the collection of samples and genome extraction are carried out earlier. From Shanghai, Anhui, 523 schizophrenia core families collected by mental hospitals in Jilin Province, the average age of patients is 27.3 ± 7.9 years old (standard deviation), of which 298 are Female; all patients met the DSM-IV (diagnostic and statistical manual of mental disorders, fourth edition) diagnostic criteria for schizophrenia, and the diagnosis of each patient was confirmed by more than two psychiatrists. All patients had clinical manifestations of hallucinations, hallucinations, delusions, disorganized thinking, and cognitive impairment. All participants were Han nationality, and signed the formal inf...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses method of detecting the mononucleotide polymorphism of schizophrenia relative gene MPZ11 and its application in diagnosing schizophrenia. The MPZ11 gene has two mononucleotide polymorphism sites located in 1q23.3 area, has rs3767444 of nucleic acid sequence as shown in SEQ ID No. 1 with polymorphism site as C allelic site and T allelic site on the DNA complementary strand; and rs2051656 of nucleic acid sequence as shown in SEQ ID No. 2 with polymorphism site as A allelic site and G allelic site on the DNA complementary strand. Genetic diagnosis kit for schizophrenia is constituted with the schizophrenia relative gene of the present invention and its polymorphism site nucleic acid sequence, and may be used in the auxiliary diagnosis susceptible judgment of schizophrenia. The present invention is favorable to the prevention, early diagnosis and treatment.

Description

technical field [0001] The invention relates to a gene MPZ11 related to schizophrenia, and also relates to a method for detecting the single nucleotide polymorphism of the MPZ11 gene and a kit for detecting the single nucleotide polymorphism of the MPZ11 gene. It belongs to the genetic field of biotechnology. Background technique [0002] Schizophrenia is a complex and destructive brain disorder with an incidence rate of about 1%. It is one of the diseases that seriously affect human mental and physical health and consumes a lot of human, material and financial resources (Hyman SE.The NIMH perspective: next steps in schizophrenia research. Biol. Psychiatry 2000b; 47: 1-7.). Although the exact cause of schizophrenia has not yet been found, sibling pair analysis, family analysis, and parasite studies have consistently shown that genetic factors play an important role in the pathogenesis (Barkur S, Shastry. Schizophrenia: A genetic perspective (Review) . Int J Mol Med 2002;9:...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
Inventor 贺林贺光刘信民冯国鄞
Owner 苏州市长三角系统生物交叉科学研究院有限公司