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High efficiency extracting method for sophora alopecuroide total alkaloid

An extraction method, the technology of Sophora sophora, applied in the direction of alkaloids, alkaloids, chemical instruments and methods, etc., can solve the problems that the extraction rate is less than 3%, only 1.5-2.5%, and the process is complicated, so as to improve the pressure of environmental treatment , High extraction rate of total alkali, and the effect of improving economic benefits

Inactive Publication Date: 2009-05-20
淮安市农业科学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the dilute acid water percolation method has the disadvantages of low product purity, time-consuming and labor-intensive; the boiling method has the disadvantages of high impurity content and easy loss of low melting point alkaloids; the resin exchange method has a large amount of eluent, low yield, and low cost. Insufficient, the extraction rate of the above three types of extraction methods is generally only about 1.5-2.5%
Chinese patent CN1273870A discloses the "Preparation Process of Sophora Sophora Total Alkali", the process of extracting total alkaloids from Sophora sophora is complicated, and the extraction yield is less than 3%, and a large amount of sewage is generated during the extraction process
It can be seen that the above-mentioned extraction method cannot effectively extract alkaloids, and the extraction efficiency is only about 25%, causing most of the alkaloids to be wasted in vain

Method used

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  • High efficiency extracting method for sophora alopecuroide total alkaloid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Such as figure 1 As shown, the specific extraction process steps are as follows:

[0045] (1) Ultra-micro-broken wall crushing: ultra-micro-broken wall-broken Sophora alopecuroides is crushed to 300 mesh ultra-fine wall-broken powder;

[0046] (2) Extraction at normal temperature: put the ultrafine broken wall powder of Sophora aphorae into the extraction tank, add a mixed solution of acidic water and methanol (containing 0.1% hydrochloric acid ), close the extraction tank, continuously stir and extract for 4 hours, draw this extract into a filter press for pressure filtration, and rinse the filter residue with methanol equivalent to 10% of the volume of the extraction solvent, and then draw the filtrate into a clarification tank;

[0047] (3) Flocculation and clarification: add 1% traditional Chinese medicine flocculation clarification agent (v / v) to the filtrate, stir continuously for 20 minutes and then let it stand for 4 hours, pump the supernatant into the concent...

Embodiment 2

[0054] The efficient method for the total alkaloids of Sophora sophora, the specific extraction process steps are as follows:

[0055] (1) Ultrafine broken wall crushing: the ultrafine broken wall of Sophora Sophorae is crushed to 400 mesh ultrafine broken wall powder;

[0056] (2) Normal temperature leaching: put the ultrafine broken wall powder of Sophora aphorae into the extraction tank, add the mixed solution of acidic water and ethanol (containing 0.1% acetic acid in the volume ratio of 2 times the mass of the ultrafine broken wall powder of Sophora sophora to the volume ratio of the extraction solvent) ), close the extraction tank, continue stirring and leaching for 6 hours, draw this extract into a filter press for pressure filtration, and wash the filter residue with 20% ethanol equivalent to the volume of the extraction solvent, and then draw the filtrate into the clarification tank;

[0057] (3) Flocculation and clarification: add 2% (v / v) fruit juice clarifier 101 t...

Embodiment 3

[0064] The efficient extraction method of total alkaloids of Sophora sophora, the specific extraction process steps are as follows:

[0065] (1) Ultra-micro-broken wall crushing: ultra-micro-broken wall-broken Sophora alopecuroides is crushed to 500 mesh ultra-fine wall-broken powder;

[0066] (2) Normal temperature leaching: put the ultrafine broken wall powder of Sophora aphorae into the extraction tank, add the mixed solution of acidic water and methanol (containing 0.1% sulfuric acid in the ratio of 3 times the mass of the ultrafine broken wall powder of Sophora sophora to the volume ratio of the extraction solvent) ), close the extraction tank, continue stirring and leaching for 6 hours, draw this extract into a filter press for pressure filtration, and rinse the filter residue with a small amount of methanol, then pump the filtrate into the clarification tank;

[0067] (3) Flocculation and clarification: add 2% (v / v) ZTC natural clarifier to the filtrate, stir continuous...

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Abstract

The high efficiency process of extracting total alkaloid of Sophora alopecuroide includes the steps of: ultra-fine wall breaking and crushing, normal temperature leaching, flocculation to clarify, concentrating, alkaline extraction, acid extraction, acid filtering, etc. The extracting process is reasonable, simple, short in flow, high in total alkaloid yield, environment friendly and suitable for industrial production.

Description

technical field [0001] The invention relates to the extraction of the total alkaloids of Sophora sophora, and aims to provide an efficient extraction method of the total alkaloids of Sophora sophora so that it can be applied to large-scale industrial production. Background technique [0002] Sophora Sophora is a plant of the genus Sophora in the family Fabaceae, distributed in temperate and subtropical regions. In my country, it is concentrated in the desert and semi-desert areas in the north, especially in Ningxia, Gansu, Qinghai, Xinjiang and Inner Mongolia. Bitter bean is a perennial herbaceous rhizome underground bud plant with strong salt tolerance. According to the survey, the natural distribution area of ​​bitter beans in Ningxia alone reaches 2×10 5 hm 2 , the total amount of bitter beans in Ningxia is 8×10 7 More than kg, only Yanchi County can harvest about 2.8×10 bitter beans per year 7 kg or more, the annual harvest of bitter beans in the Northwest is about 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07G5/00A61K36/489A61P31/04A61P31/12A61P11/04A61P11/14
Inventor 王伟中吴传万杜小凤顾大路
Owner 淮安市农业科学研究院
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