Injection for treating cardiac cerebrovascular disease and its preparation
A technology for cardiovascular and cerebrovascular diseases and refining methods, which is applied in the direction of cardiovascular system diseases, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as rebound, high price, and lack of safe and quick-acting drugs
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Embodiment 1
[0132] Astragalus 2kg Chuanxiong 20kg Radix Paeoniae Rubra 20kg
[0133] (1) Take Radix Astragali and add 80% ethanol to reflux and extract 3 times, each time add 8 times of ethanol to extract for 2 hours, recover ethanol, concentrate, adjust the pH value to 8, let it cool, add hydrochloric acid until the pH is 3, and let it sink for 48 hour, filter, then apply macroporous resin D101, wash with water to clarification, elute with 6 times the volume of 40% ethanol, then elute with 8 times the volume of 40% ethanol, collect the eluate, concentrate to contain 10g of medicinal materials, chilled for later use;
[0134] (2) Take Radix Paeoniae Rubra and add 8 times the amount of water to extract twice, extract for 2 hours each time, concentrate, add ethanol until the alcohol content reaches 40%, let it sink for 24 hours, filter, then apply macroporous resin HPD100, and wash with water To clarification, elute with 1% ammonia water, wash with water until neutral, elute with 4 times t...
Embodiment 2
[0138] Astragalus 400g Chuanxiong 20g Peony 200g
[0139] (1) Take Radix Astragali and add 45% ethanol to reflux and extract 3 times, add 5 times of ethanol to extract for 1 hour each time, recover ethanol, concentrate, adjust the pH value to 10, let it cool, add hydrochloric acid until the pH is 5, and let it sink for 72 hours, filtered, then applied to weak polar macroporous resin AB-8, washed with water until clarified, eluted with 3 times the volume of 40% ethanol, then eluted with 4 times the volume of 50% ethanol, collected the eluate, and concentrated Contain 2g of medicinal materials per ml, and cool down for later use;
[0140] (2) Take peony and add 10 times the amount of water to extract once, extract for 3 hours, concentrate, add ethanol until the alcohol content reaches 50%, let sink for 24 hours, filter, then apply macroporous resin D101, wash with water until clear, Elute with 0.5% ammonia water, wash with water until neutral, elute with 3 times the volume of 2...
Embodiment 3
[0144] Astragalus 400g Chuanxiong 200g Peony 20g
[0145] (1) Take Radix Astragali and add 80% ethanol to reflux extract once, add 10 times of ethanol to extract for 3 hours, recover ethanol, concentrate, adjust pH value to 7, let cool, add hydrochloric acid until Ph is 1, let sink for 24 hours, Filter, then the macroporous resin HPD450, wash with water to clarification, elute with 10 times volume of 20% ethanol, then elute with 10 times volume of 80% ethanol, collect the eluate, concentrate to contain 15g of medicinal material per ml, cool Standby;
[0146] (2) Take peony and add 4 times the amount of water to extract 3 times, each extraction for 1 hour, concentrate, add ethanol until the alcohol content reaches 80%, let it sink for 24 hours, filter, then apply macroporous resin AB-8, use Wash with water until clarification, elute with 5% ammonia water, wash with water until neutral, elute with 0 times the volume of 40% ethanol, then elute with 10 times the volume of 80% eth...
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