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Nanometer fluorouracil coat artificial crystal and the preparing method

A technology of fluorouracil and intraocular lens, which is applied in the field of medicine, can solve problems such as blocking the passage of light, turbidity and shrinkage, and affecting vision improvement, and achieve the effects of low intraocular toxicity, inhibiting capsule turbidity, and preventing post-cataract

Inactive Publication Date: 2009-10-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the wound healing mechanism induces fibrosis, collagen production, fibrosis of the posterior capsule, turbidity and shrinkage, which hinders the passage of light, causes crystal deviation, and affects vision improvement.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Preparation of Coated Intraocular Lens

[0070] 1. Components and ratio

[0071] Chitosan 8mg

[0072] Polyacrylic acid 40mg

[0073] Fluorouracil 100mg

[0074] Glacial acetic acid 400mg

[0075] Distilled water 752ml

[0076] Fluoride ion 5×10 13 ions / cm 2

[0077] 2. Preparation method

[0078] (1) Preparation of fluorouracil-chitosan nanoparticle suspension:

[0079] 1. Prepare solution A: dissolve 400 mg of glacial acetic acid in 40 ml of distilled water, add 8 mg of chitosan powder to swell fully at room temperature, and make 0.02% chitosan acetic acid solution A;

[0080] 2. Preparation of solution B: Dissolve 40mg of polyacrylic acid in 200ml of distilled water to prepare 0.02% polyacrylic acid solution B;

[0081] 3. Preparation of solution C: Dissolve 100mg of fluorouracil in 12ml of distilled water to obtain fluorouracil solution C;

[0082] 4. Preparation of nanoparticle suspension: under continuous stirring at 500rpm, add solution C dr...

Embodiment 2

[0088] Embodiment 2: Application of the coating intraocular lens prepared in embodiment 1 on rabbit eyes

[0089] The coated intraocular lens prepared in Example 1 was implanted into the rabbit eye:

[0090] 1. Experimental design Grouping, 20 rabbits were marked as A1-5, B1-5, C1-5, D1-5.

[0091] 2. Preoperative anesthesia: 3% pentobarbital sodium, quantitative anesthesia from the ear vein at 1ml per kg body weight, subconjunctival injection of appropriate amount of lidocaine for local anesthesia, ocular surface drip of Alcaine eye solution for surface anesthesia.

[0092] 3. After anesthesia, the rabbit was placed on its side on the rabbit platform, and the operated eye was the left eye. Routine disinfection, drapes, upper lid speculum. At point 11-1, make a conjunctival flap based on the fornix above, and at point 11-1, make a flap of reverse brow sclera 1mm posterior to the limbus, with a flap height of 2.5mm. Inject sodium hyaluronate 0.2ml, capsulorhexis forceps circ...

Embodiment 3

[0110] Example 3: Preparation of Coated Intraocular Lens

[0111] 1. Components and ratio

[0112]Chitosan 80mg

[0113] Polyacrylic acid 400mg

[0114] Fluorouracil 500mg

[0115] Glacial acetic acid 200mg

[0116] Distilled water 760ml

[0117] Fluoride ion 5×10 15 ions / cm 2

[0118] Two, the preparation method is:

[0119] (1) Preparation of fluorouracil-chitosan nanoparticle suspension:

[0120] 1. Preparation of solution A: Dissolve 200 mg of glacial acetic acid in 40 ml of distilled water, add 80 mg of chitosan powder to fully swell at room temperature, and make 0.2% chitosan acetic acid solution A;

[0121] 2. Preparation of solution B: Dissolve 400mg of polyacrylic acid in 200ml of distilled water to prepare 0.2% polyacrylic acid solution B;

[0122] 3. Preparation of solution C: Dissolve 500mg of fluorouracil in 20ml of distilled water to obtain fluorouracil solution C;

[0123] 4. Preparation of nanoparticle suspension: under continuous stirring at 600rpm,...

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Abstract

The present invention relates to intraocular lenses. At present, the polymethyl methacrylate (PMMA) intraocular lens commonly used in clinic for the treatment of cataract often causes inflammation after being implanted in the human body. Posterior capsule turbidity is also the main complication after cataract surgery. To solve these problems, the present invention selects antineoplastic drugs According to the weak penetrability of chitosan nanoparticles in the eye and the characteristics that the phagocytosis of conjunctival epithelial cells on nanoparticles is related to the size of the nanoparticles, chitosan-polyacrylic acid was used as a carrier to prepare fluorouracil nanoparticles Formulation, mixed coating on the surface of PMMA intraocular lens. The present invention also provides the preparation method of the above-mentioned intraocular lens. The invention not only increases the biocompatibility of the intraocular lens, inhibits the opacity of the posterior capsule after the implantation of the intraocular lens, but also prevents the anterior membrane and post-cataract after the implantation of the intraocular lens.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a coated intraocular lens (intraocular lens, IOL) and a preparation method thereof. Background technique: [0002] Fluorouracil (Fluorouracil, 5-Fu) is an inhibitor of thymidylate synthase, which can effectively inhibit cell mitosis and is a commonly used antineoplastic drug in clinic. Studies have found that fluorouracil can inhibit the proliferation and migration of lens epithelial cells (see Sun Yanxiu, Li Xiaorong, Zhang Xiaohong, etc., 5-fluorouracil inhibits rabbit lens epithelial cells (lens epithelial cells, LECs) proliferation and intraocular toxicity research, Ophthalmology Research, 2000 ; 18(3):224-226), which can be used to prevent intraocular lens anterior membrane and posterior cataract after intraocular lens implantation, and can also prevent scar formation after glaucoma surgery (see Xiong Xiaoling, 5-Fu anti-scar after glaucoma surgery Formation of experiment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/28A61F2/16
Inventor 魏锐利马晓晔黄潇蔡季平刘园园李由程金伟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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