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Composition of notoginsen triterpenes and tanshinone IIA sodium sulfonate

A technology of Panax notoginseng saponins and a composition, which is applied in the field of medicine and achieves the effects of improved drug efficacy, less impurities, and uniform and stable drug quality

Inactive Publication Date: 2010-01-27
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Currently using Panax notoginseng saponins and Tanshinone II A The interaction of sodium sulfonate and the compatibility of prescriptions to treat cardiovascular and cerebrovascular diseases have not been reported yet

Method used

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  • Composition of notoginsen triterpenes and tanshinone IIA sodium sulfonate
  • Composition of notoginsen triterpenes and tanshinone IIA sodium sulfonate
  • Composition of notoginsen triterpenes and tanshinone IIA sodium sulfonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Example 1: Panax notoginseng saponins and tanshinone II A Preparation of sodium sulfonate water injection

[0112] prescription:

[0113] Panax notoginseng saponins

120g

Sodium Tanshinone IIA Sulfonate

12g

Propylene Glycol

800ml

Water for Injection

Add to 1000ml

co-preparation

1000 pieces

[0114] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

30g

Propylene Glycol

800ml

Water for Injection

Add to 1000ml

co-preparation

1000 pieces

[0115] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

240g

Propylene Glycol

800ml

Water for Injection

Add to 1000ml

co-preparation

1000 pieces

[0116] Preparation Process:

[0117] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them wi...

Embodiment 2

[0128] Example 2: Panax notoginseng saponins and tanshinone II A Preparation of sodium sulfonate powder injection

[0129] prescription:

[0130] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

12g

Polysorbate 80

100g

Mannitol

300g

sterile water for injection

Add to 3000ml

co-preparation

1000 pieces

[0131] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

30g

Polysorbate 80

125g

Mannitol

350g

sterile water for injection

Add to 3500ml

co-preparation

1000 pieces

[0132] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

240g

Polysorbate 80

200g

Mannitol

450g

sterile water for injection

Add to 4000ml

co-preparation

1000 pieces

[0133] Preparation Process:

[0134] 1) Firs...

Embodiment 3

[0144] Example 3: Panax notoginseng saponins and tanshinone II A Preparation of sodium sulfonate infusion

[0145] prescription:

[0146] Sodium chloride infusion:

[0147] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

12g

Polysorbate 80

100g

Sodium chloride

900g

Water for Injection

Add to 100000ml

co-preparation

1000 bottles

[0148] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

30g

Polysorbate 80

125g

Sodium chloride

900g

Water for Injection

Add to 100000ml

co-preparation

1000 bottles

[0149] Panax notoginseng saponins

120g

Tanshinone II A Sodium sulfonate

240g

Polysorbate 80

200g

Sodium chloride

900g

Water for Injection

Add to 100000ml

co-preparation

1000 bottles

[0150...

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PUM

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Abstract

The invention belongs to the field of pharmacy, wherein a composition including the active constituents of notoginsen triterpenes and tanshinone IIA or pharmaceutically acceptable salts is disclosed, the invention also discloses the preparation containing the pharmaceutical composition and its preparing process, the composition can be made into clinically and pharmaceutically acceptable dose forms including oral liquids or injections.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a composition consisting of Panax notoginseng saponins and Tanshinone II containing medicinal components. A A pharmaceutical composition or a pharmaceutically acceptable salt thereof, a preparation containing the pharmaceutical composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases such as stroke, coronary heart disease, and angina pectoris are one of the main causes of human death. According to the report of the World Health Organization, the mortality rate of cardiovascular diseases in the world accounted for 29% of the total mortality rate in 1990, ranking second. In 1994 The number of deaths worldwide is 52.2 million in 2000, of which 15.3 million died of cardiovascular diseases, while in 1999 the number of deaths from cardiovascular diseases in the world was 16.97 million, accounting for 30.3% of the total ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K31/343A61K9/00A61P9/10
Inventor 蔡军
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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