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Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine

A technology of extracts and compositions, applied in the field of preparations containing the pharmaceutical composition and its preparation, to achieve the effects of reduced dosage, high safety, and avoidance of drug loss

Inactive Publication Date: 2011-03-23
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there is no report on the medicine of treating cardiovascular and cerebrovascular diseases by utilizing the interaction of Panax notoginseng, Salvia miltiorrhiza and Ligustrazine phosphate in combination.

Method used

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  • Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine
  • Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine
  • Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] Experimental example 1 Optimum preparation process of Panax notoginseng extract

[0031] Take the notoginseng medicinal material, crush it into a coarse powder, add ethanol to reflux and extract 3 times, each time for 3 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water to an appropriate amount (each 1m1 is equivalent to 2g of the original medicinal material), and refrigerate for 24 hours. Filtrate, add the filtrate to the treated weakly polar macroporous resin column, first elute with 2 times the column volume of water, then elute with 4 to 5 times of 80% ethanol, collect the eluate, and recover ethanol And vacuum drying, that is.

experiment example 2

[0032] Experimental Example 2: Determination of the content of Panax notoginseng total saponins in Panax notoginseng extract:

[0033] Preparation of Reference Substance Solution Take 10 mg of the reference substance of Panax notoginseng saponins, vacuum-dry it at 60°C for 2 hours, weigh it accurately, put it in a 25ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, filter with dry filter paper, Precisely measure 5ml of the continued filtrate, put it in a 25ml measuring bottle, add methanol to dilute to the mark, shake well, and you get it.

[0034] Preparation of the test solution Take 15 mg of this product, accurately weigh it, put it in a 25ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, filter with dry filter paper, accurately measure 5ml of the subsequent filtrate, and put it in a 25ml measuring bottle In, add methanol to dilute to the mark, shake well, that is.

[0035] Determination method Precisely mea...

experiment example 3

[0036] Experimental example 3 Salvia miltiorrhiza extraction process screening test

[0037] 1. Water extraction process screening test

[0038] The amount of water added, extraction time and extraction times had a great influence on the extraction results, so the content of total phenolic acids in salvia miltiorrhiza and the yield of the extract were taken as indicators, and the influence of the three factors on the extraction results was investigated by orthogonal test. The factors and level design are shown in Table 2.

[0039] Table 2 Level table of factors investigated in alcohol extraction process of Danshen

[0040] level / factor

[0041] Test method Weigh 100g of Salvia miltiorrhiza, a total of 9 parts, extract according to the requirements of each column number in Table 2, combine the extracts, filter, concentrate the filtrate and dilute to 500ml, and set aside.

[0042] Content Determination of Salvianolic Acid

[0043] Preparation of reference substanc...

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PUM

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Abstract

The invention belongs to the field of pharmacy, and discloses a medicinal composition containing pseudo-ginseng extract, red sage root extract, ligustrazine or pharmaceutically acceptable salts, which can be used for treating cardiovascular and cerebrovascular diseases, the invention also discloses the preparation containing the pharmaceutical composition and its preparing process, wherein the constituents include (by weight ratio) pseudo-ginseng extract 30-400 parts, red sage root extract 10-400 parts, ligustrazine or its pharmaceutically acceptable salts 10-400 parts, the composition can beprepared into any clinically or pharmaceutically acceptable dose forms, preferably injections.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition containing notoginseng extract, salvia miltiorrhiza extract and ligustrazine, a preparation containing the pharmaceutical composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, there are more than 3 million people who die from cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of people lost their ability to work to varying degrees, and 4% were seriously disabled. In particular, the age of its onset and death is increasingly younger, and how to effectively prevent and treat it has attracted people's attention. [0003] Cardiovascular and cerebrovascular diseases include coron...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/00A61P9/10A61P9/12A61P3/06A61K31/4965
Inventor 蔡军
Owner JIANGYIN TIANJIANG PHARMA
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