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Pharmaceutical composition of ligustrazine and carthamin yellow

A technology of safflower yellow pigment and composition, which is applied in the field of medicine to achieve the effects of improved drug efficacy, less impurities, and uniform and stable drug quality

Active Publication Date: 2009-03-25
HAINAN SIHUAN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using the interaction between ligustrazine and safflower yellow pigment, there is no report on the medicine for the treatment of cardiovascular and cerebrovascular diseases in combination.

Method used

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  • Pharmaceutical composition of ligustrazine and carthamin yellow
  • Pharmaceutical composition of ligustrazine and carthamin yellow
  • Pharmaceutical composition of ligustrazine and carthamin yellow

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Embodiment 1 Preparation of the aqueous injection of the composition

[0100] prescription:

[0101] Ligustrazine Phosphate 50g

[0102] Safflower Yellow 50g

[0103] Add water for injection to 2000ml

[0104] A total of 1000 sticks were prepared

[0105] Preparation Process:

[0106] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0107] 2) Take water for injection with a dosing volume of 80%, add ligustrazine phosphate and safflower yellow in the prescribed volume, heat and stir to dissolve completely.

[0108] 3) Add water for injection to the full amount.

[0109] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0110] 5) Decarburization by sand filter stick filtration. Measure and adjust the pH of the solution.

[0111] 6) Fine filtration through a 0.45um microporous membrane.

[0112] 7) Check the clarity o...

Embodiment 2

[0117] Embodiment 2 Preparation of powder injection of this composition

[0118] prescription:

[0119] Ligustrazine Phosphate 50g

[0120] Safflower Yellow 50g

[0121] Mannitol 300g

[0122] Add sterile water for injection to 3000ml

[0123] A total of 1000 sticks were prepared

[0124] Preparation Process:

[0125] 1) First, aseptically treat the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc.

[0126] 2) Weigh the raw and auxiliary materials according to the prescription quantity.

[0127] 3) Take sterile water for injection with a dosing volume of 80%, add ligustrazine phosphate and safflower yellow into it, heat and stir to dissolve completely. Then add mannitol, heat and stir to dissolve completely, and add sterile water for injection to the full amount.

[0128] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0129] 5) Decarburization by sand filter stick filtration. M...

Embodiment 3

[0135] Embodiment 3 The preparation of this composition sodium chloride injection

[0136] prescription:

[0137] Ligustrazine Phosphate 50g

[0138] Safflower Yellow 50g

[0139] Sodium chloride 900g

[0140] Add water for injection to 100000ml

[0141] A total of 1000 bottles were prepared

[0142] Preparation Process:

[0143] 1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use.

[0144]2) Add ligustrazine phosphate and safflower yellow into water for injection with a dosing volume of 20%, heat and stir to dissolve completely. Dissolve the sodium chloride completely with water for injection with a dosing volume of 40%.

[0145] 3) Combine the two solutions and add water for injection to the full amount.

[0146] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0147] 5) Decarburization by sand filter stick filtration. Measure a...

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Abstract

Disclosed is a pharmaceutical composition and its preparing method and use thereof, wherein the composition comprises ligustrazine or its pharmaceutically acceptable salts and carthamus tinctorius yellow color, the range of the weight ratio of the two ingredients is 1:0.01-50, the two ingredients can be used individually or mixed with medicinal auxiliary materials so as to prepare clinically and pharmaceutically acceptable dose forms such as injections, constant release oral dosage forms, slow release and controlled release dosage forms, granules, pills and oral liquid preparations.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition containing ligustrazine or a pharmaceutically acceptable salt thereof, safflower yellow, a preparation containing the pharmaceutical composition and a preparation method thereof. [Background technique] [0002] In recent years, as our country has gradually stepped into an aging society, people's living standards have improved, the pace of life has accelerated, and eating habits have developed towards high fever and high fat. Cardiovascular diseases such as heart disease and stroke have become a threat to human health and life. It is one of the most serious diseases and one of the important causes of serious disability and death of human beings. Therefore, to reveal the mechanism of the occurrence and development of cardiovascular and cerebrovascular diseases, to carry out effective prevention, treatment and rehabilitation, and to reduce disability an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61P9/00A61P9/10A61P7/02A61K31/352
Inventor 蔡军
Owner HAINAN SIHUAN PHARMA
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