Medicine composition for treating hyperosteogeny, and its preparing method

A technology of bone hyperplasia and composition, which is applied in the field of pharmaceutical composition and its preparation, can solve the problems of easy recurrence of the disease, cure the symptoms but not the root cause, and unsatisfactory curative effect, and achieve the problem of easy moisture absorption, occurrence of safe toxicity, and occurrence of obvious toxicity Effect

Active Publication Date: 2007-07-25
CHONGQING TAIJI INDAL GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Western medicine has no effective treatment for hyperosteogeny and bone spurs. Symptomatic treatment is usually used, and surgical treatment is used in severe cases. However, the curative effect of these methods is not ideal. They only treat the symptoms but not the root cause, and the disease is prone to recurrence
Traditional Chinese medicine has its own advantages in the treatment of hyperosteogeny and bone spurs. Chuanlong bone spur tablets, which have been included in the 14 volumes of "Drug Standards of the Ministry of Health of the People's Republic of China-Chinese Medicine Prescriptions", have been used to treat bone spurs and death diseases. It has been on the market for more than 10 years, with definite clinical curative effect and remarkable effect, but there are disadvantages such as backward technology and large dosage

Method used

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  • Medicine composition for treating hyperosteogeny, and its preparing method
  • Medicine composition for treating hyperosteogeny, and its preparing method
  • Medicine composition for treating hyperosteogeny, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] Experimental Example 1 Screening Test of Drug Efficacy in Extraction Process

[0031] Raw materials include glycosides, terpenes, alkaloids, sterones and other compounds, so the following three extraction methods are used for drug efficacy screening tests, (a) boiling and alcohol precipitation; (b) macroporous resin purification: (c) Dilute alcohol extraction, and then alcohol precipitation. The results are shown in Table 1, Table 2, Table 3 and Table 4.

[0032] Selection of extraction process route

[0033] (1) Preparation of experimental samples

[0034] A Boiling and alcohol precipitation: Weigh 162g of Chuanshanlong, 194.4g of Epimedium, 259.2g of Goji, 259.2g of Sichuan Achyranthes bidentata, 162g of Rehmannia glutinosa, and 97.2g of Lycium barbarum according to the prescription ratio. Take Chuanshanlong and add water (15 times the amount) to decoct for 1 hour, filter, and use the filtrate for later use. Combine the dregs with the remaining 5 herbs, add water (...

experiment example 2

[0068] Experimental example 2 Orthogonal experiment in extraction process

[0069] According to the pharmacodynamic experiment index, Chuanshanlong, Gouji, Rehmannia glutinosa and Fructus Lycii are extracted with 60% ethanol, the main factors affecting the extraction effect are the amount of alcohol (A), the number of refluxes (B), and the reflux time (C). Prescription ratio Weigh 78g of crude drug, and take diosgenin in the extract as an investigation index; Epimedium and Achyranthes bidentata are extracted with water, and water consumption (A), decoction times (B), and decoction time (C) are The main factors that affect the extraction effect, take 37g of crude drug according to the prescription ratio, take icariin in the extract as the investigation index, press 3 factors, each factor 3 levels, use L 9 (3 4 ) Orthogonal test, and use the intuitive analysis method of orthogonal test for analysis. The results of the orthogonal test of diosgenin and icariin are shown in Table...

experiment example 3

[0111] Experimental Example 3 The amount of water washing after loading the column in the extraction process

[0112] Chuanlong bone spur extract 320ml (20g crude drug), D 101 Type macroporous resin 10g (dry product), put on the column by wet method, after the upper column liquid flows out, wash with water until the effluent is light yellow, collect 6 parts in total, each part is about 20ml, evaporate to dryness in a water bath, and the residue is washed with methanol Dissolved for TLC examination, no icariin and diosgenin were detected. Therefore, wash with 6 times the amount of water.

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Abstract

A Chinese medicine for treating hyperosteogeny is prepared from 6 Chinese-medicinal materials including epimedium, Sichuan achyranthes root, rehmannia root, wolfberry fruit, etc. Its preparing process is also disclosed.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating hyperosteogeny and a preparation method thereof. Background technique [0002] Osteoarthritis is a disease with a relatively high incidence rate, which seriously endangers the health of patients. The main clinical manifestations are upper limb paralysis, shoulder and back pain, difficulty in walking, and a series of pathological changes such as inability to squat down. Doctor trained in Western medicine still has no effective treatment medicine to hyperosteogeny, bone spur, usually adopts symptomatic treatment, carries out surgical treatment when serious, but these methods curative effect is all unsatisfactory, only treats the symptoms but not the disease, and the state of an illness easily recurs. Traditional Chinese medicine has its own advantages in the treatment of hyperosteogeny and bone spurs. Chuan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P19/10
Inventor 肖铭玉卿玉玲秦剑胡莉李卿赵嘉将
Owner CHONGQING TAIJI INDAL GROUP
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