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Preparation method of betaine preparation with low sodium chloride content and low hygroscopicity

A low hygroscopicity, betaine technology, applied in the preparation of organic compounds, chemical instruments and methods, cyanide reaction preparation and other directions, can solve the problem of lack of low-cost and high-efficiency separation and purification methods, and achieve broad promotion prospects and market value, The separation method is simple and the effect of improving the stability

Active Publication Date: 2021-05-11
山东祥维斯生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, the prior art lacks a low-cost and high-efficiency separation and purification method for feed grade betaine on an industrial scale, and a betaine preparation with moisture resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Betaine purification and preparation

[0052] (1) After betaine is prepared as main raw material with chloroacetic acid, sodium hydroxide, trimethylamine, 1.25kg of the product mixed solution that will contain betaine, sodium chloride evaporates and concentrates at 110 ℃ in the falling film concentrator, concentrates to Stop concentrating when feed liquid begins to separate out solid, feed liquid is transferred in the vacuum distillation crystallization still and regulate pH to be 8, when distilling to water content at 105 ℃, be cooled to 60 ℃, add 45ml methyl alcohol (about 100% of water) Weight 15wt%) as a betaine co-solvent, stir and mix evenly, filter, collect the precipitated solid 1 (mainly sodium chloride component), and move the filtrate to a vacuum rotary evaporator.

[0053] (2) Under the vacuum condition of -0.06Mpa and the temperature of 100°C, the filtrate was evaporated until the water content was 15%, the evaporation was stopped, the temperature was lower...

Embodiment 2

[0060] (1) After preparing betaine with chloroacetic acid, sodium carbonate and trimethylamine as the main raw materials, 116.8kg of the product mixed solution was evaporated and concentrated at 110°C until the feed liquid precipitated solids, and the feed liquid was transferred to a vacuum distillation crystallization kettle and adjusted When the pH is 7.5, vacuum distill at 105°C until the water content is 35.8%, cool down to 60°C, add 5.6L of methanol as betaine co-solvent, stir and mix evenly, filter, collect the precipitated solid 1, and move the filtrate to vacuum in a rotary evaporator.

[0061] (2) Under the vacuum condition of -0.06Mpa and the temperature of 105°C, evaporate the filtrate until the water content is 15%, stop evaporation, cool down to 70°C, filter and separate the precipitated solid to obtain crystalline solid 2; filter the mother liquor in the crystallizer Slowly and uniformly cool in the medium, cooling crystallization, in the whole cooling crystalliz...

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Abstract

The invention relates to a method for separating and purifying betaine, which comprises the steps of mother liquor pretreatment, step-by-step gradient crystallization primary separation, combined crystallization and refining. In addition, it also relates to a method for preparing a betaine preparation with low sodium chloride content and low hygroscopicity, which includes further performing an anti-coagulation treatment step on the purified betaine. The product obtained by the invention has uniform particle size and good fluidity, greatly reduces the hygroscopicity of the product, improves the stability of the product, and has excellent compounding performance with other components. At the same time, no waste liquid is discharged during the purification process of the present invention, the main by-product is high-purity sodium chloride, the purification cost is low, the method is suitable for large-scale industrial production, and has broad application prospects and market value.

Description

technical field [0001] The invention relates to the field of betaine purification and preparation thereof, in particular to a feed-grade high-purity betaine preparation with excellent fluidity and low hygroscopicity. Background technique [0002] Betaine, also known as trimethylglycine, is a kind of quaternary ammonium alkaloid, which is a colorless or slightly brown crystalline compound. As a high-efficiency methyl donor, betaine can promote animal fat metabolism, relieve stress, regulate osmotic pressure, promote livestock growth, increase body weight and egg production, and improve feed utilization. More and more used in feed additives. [0003] At present, the preparation methods of betaine are mainly divided into two methods: biological extraction and separation and chemical synthesis. As the demand for betaine is also increasing, the biological extraction method of extracting and separating from beet molasses is far from meeting the production needs, and the purifica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/40C07C227/42C07C229/12A23K20/142
CPCA23K20/142C07C227/40C07C227/42C07C229/12
Inventor 马琳马兴群韩强毛秀立
Owner 山东祥维斯生物科技股份有限公司
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