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Dampproof Chinese medicine sranular agent and its preparing method

A technology of traditional Chinese medicine granules and traditional Chinese medicine powder, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Properties, overcoming the effect of easy to absorb moisture

Inactive Publication Date: 2006-06-07
天津天士力大健康产业投资集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, commercially available granules are made of single or unreasonable combinations of starch, lactose, microcrystalline cellulose, sucrose, mannitol, etc. The granules are loose and the yield rate is low. A series of problems such as adhesion, agglomeration, color difference, decomposition, and mildew

Method used

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  • Dampproof Chinese medicine sranular agent and its preparing method
  • Dampproof Chinese medicine sranular agent and its preparing method
  • Dampproof Chinese medicine sranular agent and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Embodiment 1 prepares the myrrha (system) moisture-proof granule 1000g of optimized adjuvant combination, proportioning

[0107] Take by weighing Myrrha (system) medicinal powder 600g, microcrystalline cellulose 150g, calcium sulfate 120g, pregelatinized starch 80g, calcium hydrogen phosphate 50g cross 80 mesh sieves and mix, moisten soft material with 85% ethanol, pass 24 Make granules through mesh sieve, slowly heat up and dry, granulate, and dry at 60°C until the moisture content is below 3%.

[0108] Attached moisture absorption acceleration experiment comparison chart further illustrates the beneficial performance of the present invention ( figure 1 ):

[0109] Appearance of sample A in accelerated moisture absorption test: good fluidity, dryness, and no color change.

[0110] Appearance of sample B in accelerated moisture absorption test: adhesion, a small amount of particles dissolve, and heavy color difference.

Embodiment 2

[0111] Example 2 Preparation of Polyporus anti-moisture granules 1000g of optimized auxiliary material combination and proportioning

[0112] Weigh 600g of Polyporus medicament powder, 130g of microcrystalline cellulose, 170g of calcium sulfate, 80g of pregelatinized starch, and 20g of calcium hydrogen phosphate, mix through an 80-mesh sieve, moisten the soft material with 85% ethanol, and pass through a 24-mesh sieve The granules are dried by slowly raising the temperature, sized, and dried at 60°C until the moisture content is below 3%.

[0113] Attached moisture absorption acceleration experiment comparison chart further illustrates the beneficial performance of the present invention ( figure 2 ):

[0114] Appearance of sample A in accelerated moisture absorption test: good fluidity, dryness, and no color change.

[0115] Appearance of sample B in accelerated moisture absorption test: adhesion, a small amount of particles dissolve, and heavy color difference.

Embodiment 3

[0116] Example 3 Preparation of Zhuru Moistureproof Granules 1000g with Optimized Excipient Combination and Proportion

[0117] Weigh 680g of Zhuru medicinal powder, 200g of microcrystalline cellulose, 70g of calcium sulfate, and 50g of calcium hydrogen phosphate, pass through an 80-mesh sieve and mix evenly, moisten the soft material with 95% ethanol, pass through a 24-mesh sieve to make granules, slowly heat up and dry, Whole grains, dried at 60°C until the moisture content is below 3%.

[0118] Attached moisture absorption acceleration experiment comparison chart further illustrates the beneficial performance of the present invention ( image 3 ):

[0119] Appearance of sample A in accelerated moisture absorption test: good fluidity, dryness, and no color change.

[0120] Appearance of sample B in accelerated moisture absorption test: adhesion, partial dissolution of particles, heavy color difference.

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Abstract

The dampproof Chinese medicine granule consists of Chinese medicine powder accounting for 18-90 wt%, and supplementary material, which is one or several selected from microcrystal cellulose, calcium sulfate, pre-gelatinized starch, soluble starch, lactose and calcium biphosphate. Its preparation process includes the following steps: mixing Chinese medicine powder and supplementary material in certain weight ratio and sieving; adding proper adhesive to prepare soft material; sieving and pelletizing; heating to dry and finishing. The dampproof Chinese medicine granule has the advantages of high flowability, good shape and being dampproof.

Description

technical field [0001] The invention relates to the field of moisture-proof technology, in particular to the field of moisture-proof technology of traditional Chinese medicine granules. Background technique [0002] Today, under the "wave of returning to nature", the development of traditional Chinese medicine is increasingly on the agenda. Traditional Chinese medicine granules have the advantages of decoctions, syrups, and powders, and they have quick onset, good fluidity, accurate dosage, and are convenient for packaging, transportation, storage, and administration. The bioavailability is better than that of tablets, and the preparation process is less than that of tablets and injections. [0003] All or most of the medicinal materials in granules are refined by water extraction or alcohol extraction, the volume is reduced, the transportation, carrying and taking are convenient, and the taste is sweet. Patients are willing to take it, and c...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K9/16A61K47/36A61K47/38
Inventor 闫希军朱永宏杨宁武文红陈鸿捷王利民
Owner 天津天士力大健康产业投资集团有限公司
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