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Tuberculosis treating and preventing agent

A technology of tuberculosis, medicine, applied in the field of treatment and prevention of tuberculosis

Inactive Publication Date: 2007-08-01
OOO百日瑞有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the anti-tuberculosis (tuberculosis-killing) effect of poplar bark extract can only be tested in vitro

Method used

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Experimental program
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Effect test

Embodiment Construction

[0017] Unlike the Russian patent 2210379, the activity of the drugs included in the present invention is confirmed not only in vitro but also in vivo.

[0018] In addition, the preventive effects of betulin and birch bark extract on tuberculosis were discovered; for poplar bark extract, the effect has not been studied.

[0019] The in vivo test of betulin is directed against the exudative necrotic tuberculosis model in mice, and the in vitro test is directed against the macrophage cultures infected with MBT (M Mycobacterium tuberculosis). The following issues have been resolved:

[0020] 1. The survival index of animals infected with a lethal dose of MBT was tested in different experimental animal groups.

[0021] 2. In vivo microbial detection of possible bacterial growth inhibition and antibacterial activity of the drug.

[0022] 3. Morphological study of the essence of the repair process of the parenchymal organs in the experimental tuberculosis treatment of mice in the researc...

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PUM

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Abstract

The possibility of using betulin and birch bark containing said betulin for treating and preventing tuberculosis is disclosed.

Description

Technical field [0001] The invention relates to medicines and veterinary medicines, in particular to the treatment and prevention of tuberculosis. Background technique [0002] After the long-term decline in human tuberculosis mortality seen in the middle of the 20th century (in Russia until the 1990s), the epidemic situation of the disease deteriorated sharply. In April 1993, the World Health Organization (WHO) declared tuberculosis a "global emergency". In fact, according to WHO data, one third of the world's population is infected with tuberculosis. [0003] In Russia, the number of new tuberculosis cases detected every year is 75,000-85,000. In 1999, there were nearly 100,000 cases. Tuberculosis accounts for 75% of deaths from infectious diseases. [0004] The treatment of tuberculosis, even for ordinary (drug-sensitive) tuberculosis, is a long-term process, and several (4-5) anti-tuberculosis drugs are used. The standard treatment regimen (DOTS treatment) for common (drug-se...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K129/00A61P31/06A61K31/00A61K31/045A61K36/185
CPCA61K31/045A61K36/185A61P31/06A61K2300/00
Inventor I·V·博恰罗夫O·V·德米卡赫夫V·V·叶罗欣L·E·波斯佩罗夫V·V·巴拉金A·N·切斯塔科夫P·G·德丽亚宾V·J·米申
Owner OOO百日瑞有限公司
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