Short peptide for inhibiting Shiga toxin and application thereof

Abstract

The invention discloses a making method of short peptide to inhibit shigellosis with amino acid as list 1, which is characterized by the following: adding chemical group, amino acid, peptide, protein, PEG, marked material to N and C ends to do kinds of chemical or biological decoration; optimizing the stability or other applying property and using scale; fitting for treat shigellosis, enterorrhagia escherichia coli O157 and cholera vibrio.

Description

A short peptide inhibiting Shiga toxin and its application technical field The present invention relates to a biological toxin inhibitor, in particular to a short peptide capable of inhibiting Shiga toxin, and also to a preparation method and application of the short peptide. Background technique Shiga toxin (Stx) is a kind of bacterial exotoxin with enterotoxicity, cytotoxicity and neurotoxicity produced by enteropathogenic bacteria, and is the most critical for emerging enteropathogens such as acute bacillary dysentery, cholera O139, O157:H7, etc. potent virulence factor. Clinically, it causes serious complications such as hemorrhagic colitis (hemorrhagiccolitis, HC), thrombotic thrombocytopenic purpura (TTP), and hemolytic uremia (hemolytic uremic syndrome, HUS) with a mortality rate as high as 80-90%. caused millions of deaths worldwide. At present, there are no specific and effective preventive products and emergency treatment drugs for Shiga toxin. Antibiotic tre...

AI Technical Summary

Problems solved by technology

Peptide inhibitors against Shiga toxins have not been reported so far

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