Glucocorticoid receptor antagonists for treatment of dementia

A technology of glucocorticoids and receptor antagonists, applied in the field of psychiatry, can solve the problems of reducing the speed of cognitive decline, dementia etiology and treatment inconsistency

Inactive Publication Date: 2003-12-10
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, it is clear that until now we have not agreed on the etiology and treatment of dementia.
Prior to the present invention, no treatment regimen was effective in treating dementia or reducing the rate of cognitive decline in diseases such as Alzheimer's disease or multi-infarct dementia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Example 1: Treatment of dementia with mifepristone

[0121] The following examples illustrate studies that demonstrated that the methods of the present invention are effective in the treatment of dementia.

[0122] Research Background

[0123] The study demonstrates that mifepristone, a glucocorticoid receptor (GR) antagonist given daily at doses of approximately 200 mg, is an effective treatment for slowing early cognitive decline in Alzheimer's disease.

[0124] patient choice

[0125] Patients in this study were diagnosed with early Alzheimer's disease using subjective and objective criteria, including those proposed by the National Institute of Neurological Diseases and Stroke (NINCDS) and DSM-IV described above. Mer's disease. All patients gave written consent to a protocol certified by the Human Subjects Committee at Stanford University Medical Center.

[0126] Only patients diagnosed with Alzheimer's dementia and confirmed by two psychiatrists were eligible t...

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PUM

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Abstract

This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating dementia. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating dementia in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

Description

[0001] Related Application Cross Documentation [0002] This application is a PCT application of US Provisional Application No. 60 / 085,703, filed May 15,1998. The foregoing application is hereby incorporated by reference in its entirety for all purposes. field of invention [0003] The present invention relates generally to the field of psychiatry. In particular, the present invention relates to the discovery that drugs that inhibit the binding of cortisol to its receptors are useful in the treatment of dementia. Background of the invention [0004] Dementia is the loss of the ability to think and remember. The disease affects thousands of individuals, especially older adults, and is becoming more common as the population ages. Usually, this loss of cognitive skills and memory is slow and progressive over months or years. To date there is no effective treatment that stops, slows or reverses thi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/00A61K31/565A61K31/569A61K45/00A61P25/28A61P43/00
CPCA61K31/00A61K31/575A61K31/569A61K31/567A61P25/28A61P43/00A61K31/565
Inventor A·F·沙茨伯格J·K·贝拉诺夫
Owner THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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