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33results about How to "Play an anti-allergic effect" patented technology

Method for extracting peony essence from fresh peony flowers

ActiveCN103305344APreserve the spice ingredientsRetain activityEssential-oils/perfumesBiotechnologyOrganic solvent
The invention belongs to the field of extraction of plant essential oil and in particular discloses a method for extracting peony essence from fresh peony flowers. The method comprises the following steps: performing supercritical CO2 extraction on the fresh peony flowers as raw materials to prepare peony extract, and extracting the peony extract to obtain the peony essence by employing a molecular distillation method. According to the method, since the fresh peony petals are taken as the raw materials, the spice components, thermal-sensitive substances and other active ingredients in the peony petals are maintained to the greatest extent, desensitization treatment is performed in the extraction process of essential oil, the condition that some people have pollen allergy is avoided; since the peony essential oil is extracted through the supercritical CO2 extraction method, the phenomenon that the thermal-sensitive substances in the peony flowers are lost because of heating in the traditional method is avoided; and meanwhile, the residue problem of the harmful substances caused by extraction by employing an organic solvent and the treatment and recovery problems of the organic solvent are solved, the environmental pollution is reduced, and the energy consumption is reduced.
Owner:HEZE YAO & SHUN PEONY BIOTECH

Method for extracting essential oil from peony flowers

The invention discloses a method for extracting essential oil from peony flowers. The method comprises the following steps: (1) picking fresh peony petals, adding salt which is 20% to 30% of the peony petals by weight for 3-5 days' pickling; adding distilled water which is 3 to 5 times of the peony petals by weight for crushing of the peony petals; (2) extraction: adding purslane and an extraction agent which are respectively 1-3% and 3-5% of the peony petals by weight; adopting a probe-type ultrasonic generator for 30-50 minutes' ultrasonic extraction; carrying out filtering; collecting the filtrate; adding an ethyl alcohol solution with the mass concentration of 80-90% into the obtained filter residue; repeating ultrasonic extraction and filtration for two times; combining all the filtrates; (3) conducting separation on the mixed liquor with a centrifuge at 5000-6000 revolutions per minute; taking a supernatant; carrying out decompressing and removing of an organic solvent under a thermostatic water-bath condition to obtain the essential oil. The method provided by the invention has the advantages that the extracting time is short, the extraction efficiency is high, the situation that the extracted essential oil contains residual peony pollen is avoided to realize the hypoallergenic function, and reduce the harm to users of allergic constitution.
Owner:芜湖市丹洋现代农业科技发展有限公司

Perfume

The invention aims to provide perfume capable of reducing and even avoiding the volatizing of effective components. The perfume comprises, by weight, 75-90 parts of ethanol, 3-7 parts of water, 5-20 parts of glycerin-natural perfume mixture, wherein the glycerin-natural perfume mixture comprises 10-20wt% of glycerin and 80-90wt% of natural perfume. The perfume has the advantages that the difference of the effective component content of the natural perfume in the perfume of different batches is small, perfume quality can be controlled favorably, and large-scale production of high-end perfume is benefited; meanwhile, the raw material source of the perfume is strictly controlled, the perfume is natural and nonirritant, the skincare possibility of the perfume is increased, and the perfume has a certain anti-allergic effect.
Owner:HANGZHOU XINYUE COSMETICS CO LTD

Antiallergic composition, preparation method thereof, antiallergic cosmetic and preparation method thereof

The invention relates to an antiallergic composition, a preparation method thereof, an antiallergic cosmetic and a preparation method thereof. The antiallergic composition comprises, by weight, 1-5 parts of Opuntia streptacantha stem extract, 1-5 parts of heartleaf houttuynia herb extract, 1-5 parts of Chrysanthellum indicum extract, 1-5 parts of tree peony root-bark extract, 1-5 parts of purslaneherb extract, 1-5 parts of skullcap root extract, and 0.1-2 parts of ectoin. By adopting the substances above and limiting the proportion of the substances, the antiallergic composition can play a good role in relieving and relieving allergic symptoms and can more effectively play an anti-allergic role, and side effects of the antiallergic composition are reduced, so that the antiallergic composition has a long service life.
Owner:广州诺胜化妆品有限公司

Whitening composition and application thereof

InactiveCN104188887ASignificant freckle removalVisible skin brightening effectCosmetic preparationsToilet preparationsIrritationSkin color
The invention discloses a whitening composition and the application thereof in whitening cosmetics. The whitening composition contains the following components in weight percentage: 1-10% of lipid soluble VC derivatives, 0.05-0.2% of Glabridin, 1-5% of nicotinamide, 1-5% of hydrogenated soya lecithin, 0.1-0.5% of a gorgonia extracting solution and 0.5-2% of an amino-acid humectant. According to the whitening composition prepared by the invention, the whitening and speckle removing effects are obvious, the whitening composition can be quickly adsorbed by skin, the irritation to the skin is weak and the obvious moisture-holding, anti-inflammatory and antiallergic effects and effective skin brightening effect are realized.
Owner:广东真丽斯化妆品有限公司

Anti-allergy composition

The invention provides anti-allergy composition. The anti-allergy composition is prepared from a traditional Chinese medicine mixture, an anti-inflammatory agent, a humectant, a preservative and an antioxidant, wherein the anti-inflammatory agent can effectively inhibit secretion of inflammatory factors and resist inflammation effectively, and the allergy resisting purpose is achieved; the antioxidant can protect lipid of a cell membrane from overoxidation, relieve inflammatory response and indirectly play an allergy resisting role; the traditional Chinese medicine mixture can improve cell viability and strengthen skin health. The anti-allergy composition can effectively help the skin resist invasion of sensitive substances, improve cell viability and have the anti-inflammatory and anti-allergy effects, and after the composition is applied to cosmetics, the cosmetics can be endowed with good moisturizing, whitening and allergy resisting effects.
Owner:FOSHAN JUCHENG BIOCHEM TECH RES & DEV CO LTD

Edible fungus lip balm and preparation method thereof

The invention belongs to the field of skin care product preparation and particularly relates to edible fungus lip balm and a preparation method thereof. The edible fungus lip balm comprises, by weight parts, 5-7 parts of pholiota nameko, 10-15 parts of pholiota nameko, 7-8 parts of lentinula edodes, 9-11 parts of coix seed extracting solution, 12-13 parts of honey, 19-22 parts of beeswax and 6-8 parts of almond oil. Fresh pholiota nameko and lentinula edodes are soaked into the coix seed extracting solution, and nutritional ingredients of pholiota nameko and lentinula edodes can be extracted efficiently; and pholiota nameko is soaked in the honey, so that glairing and nutritional ingredients on the surface of pholiota nameko are fully fused with the honey. The manufactured lip balm is rich in nutritional ingredients of edible fungi and can supplement various required vitamins and the like against xerochilia and cleft lip and the like.
Owner:福建绿宝食品集团有限公司

Chiral tricyclic compounds with anti-histamine activity, preparation method and application

The invention discloses chiral tricyclic compounds with anti-histamine activity, a preparation method and application. The chiral tricyclic compounds with the anti-histamine activity have a structural formula, wherein when R1 is phenyl or hydroxyalkyl, ester alkyl or carboxyalkyl of C1 to C11, R2 is straight-chain alkyl of C1 to C7; R3 is hydrogen or alkyl of C1 to C4; R4 is hydrogen or alkyl of C1 to C4; R5 is hydrogen or alkyl of C1 to C4; and R6 is hydrogen or alkyl of C1 to C4. Experiments prove that the chiral tricyclic compounds with the anti-histamine activity can be competitively combined with the body H1 receptor to block the action of the histamine and the H1 receptor so as to restrain the biological effect of the histamine and play a role in allergic resistance. The experiments show that the compounds have stronger anti-histamine activity compared with a positive contrast chlorpheniramine group.
Owner:TIANJIN UNIV

Traditional Chinese medicine ointment for treating infantile eczema, and preparation method of traditional Chinese medicine ointment

The invention discloses traditional Chinese medicine ointment for treating infantile eczema, and a preparation method of the traditional Chinese medicine ointment. The traditional Chinese medicine ointment for treating the infantile eczema is prepared from the following formula components in parts by weight: 5-12 parts of radix sophorae flavescentis, 8-15 parts of tomato fruit, 5-10 parts of fragrant-flowered garlic, 10-15 parts of cortex phellodendri, 5-10 parts of egg yolk, 5-10 parts of cotex dictamni, 2-5 parts of folium artemisiae argyi, 3-4 parts of root of siberian cocklebur, 3-8 partsof gypsum, 2-5 parts of rhizoma dioscoreae, 3-8 parts of radix asparagi, 2-5 parts of cortex acanthopanacis, 3-5 parts of periostracum cicadae, 5-10 parts of sulphur, 10-15 parts of bamboo leaves, 15-30 parts of semen coicis, 3-8 parts of longan seed, 10-15 parts of vegetable oil and 8-15 parts of snakehead skull. The traditional Chinese medicine ointment, provided by the invention, for treating the infantile eczema can effectively relieve itching and has an anti-allergic effect during treatment under the actions of the tomato fruit and the fragrant-flowered garlic, thus effectively curing theinfantile eczema; furthermore, and the snakehead skull is rich in absorbable calcium substance, so that the traditional Chinese medicine ointment improves the skin and prevents recurrent episodes ofthe eczema.
Owner:郑州百典药业有限公司 +1

Antipruritic sterilizing repair solution and preparation method thereof

InactiveCN109620861AGood skin affinityStrong anti-itch and bactericidal abilityAntibacterial agentsOrganic active ingredientsSide effectMedicine
The invention discloses an antipruritic sterilizing repair solution and a preparation method thereof. The antipruritic sterilizing repair solution includes, by weight parts, 0.02-0.2 part of alkannin,10-16 parts of tea tree essential oil, 0 .1-0.8 part of glycyrrhetic acid 3-O-mono-beta-D-glucuronide, 5-10 parts of dromiceius oil and 73-85 parts of base oil. The repair solution for treating footrot is convenient to use, has no toxic and side effects, strong antipruritic sterilizing capability and can effectively promote the rapid recovery and healing of the skin of the affected part.
Owner:南京紫源康医药科技有限公司

A medicine for treating rhinitis

A medicine for treating rhinitis is provided. The medicine is paste prepared from herba centipedae, borneol, angelica dahurica, flos magnoliae, menthol, Furacilin powder, a watermelon frost, vaseline, sesame oil, and the like. Using results show that the medicine utilizes comprehensive functions of each medicine to treat the rhinitis, has anti-inflammation, sterilizing and antiallergic functions and is non-toxic and harmless to human bodies and convenient to use, medicine taking can be performed by only one person, and normal study and working are not influenced after medicine taking. The medicine is good in treating effects, and largely increases the curative rate of chronic rhinitis, nasosinusitis and allergic rhinitis.
Owner:高法彬

Preparation method of physalis alkekengi extract and application of physalis alkekengi extract as bulk drug

The invention discloses a preparation method of a physalis alkekengi extract and application of the physalis alkekengi extract as a bulk drug. The physalis alkekengi extract is prepared from a physalis alkekengi medicinal material as a raw material; a method for preparing the physalis alkekengi extract is simple; the raw material is easy to obtain; in research on application of the physalis alkekengi extract as the bulk drug, the prepared physalis alkekengi extract is used for preparing a solution, namely a physalis alkekengi extracting solution, according to the required mass concentration; the physalis alkekengi extract serves as the bulk drug to be applied to inhibition of hyaluronidase, inhibition of release of histamine in RBL-2H3 cells and inhibition of growth of propionibacterium acnes and staphylococcus epidermidis; and by the application, it is found that the calyx physalis alkekengi extract serving as the bulk drug has the functions of resisting allergy and treating allergic reaction, and meanwhile, the physalis alkekengi extract serving as the bulk drug can also treat acne.
Owner:广东安道医疗器械有限公司

Rupatadine fumarate emulsion type nasal spray agent and preparation method thereof

The invention relates to the biomedical technical field, and in particular, relates to a rupatadine fumarate emulsion type nasal spray agent and a preparation method thereof. A prescription of nasal drops contains the following medicinal-grade components by mass: 2-5% of rupatadine fumarate, 5-25% of an oil phase, 10-20% of an emulsifier, 40-65% of an aqueous phase, 0.5-5% of an osmotic pressure regulation agent, 0.05-0.1% of a bacteriostatic agent, and 0.5-5% of a pH regulator. A nose drop liquid is prepared by emulsification with a high-speed shearing homogenizer, aseptic operation is carried out, and the nose drop liquid are sub-packed in a special spray device.
Owner:扬子江药业集团江苏紫龙药业有限公司

Preparation method of medical ozone ice

The invention relates to a preparation method of medical ozone ice, which comprises the following steps: S1. preparing double distilled water or ultrapure water, and injecting the double distilled water or ultrapure water into a closed container; S2. introducing ozone gas into the double distilled water or ultrapure water in the step S1 until the ozone is saturated and dissolved, thereby obtaining ozone water; and S3. filling the ozone water in the step S2 into ice making molds, and carrying out fast freezing to obtain the medical ozone ice. The method is quick and efficient. The prepared ozone ice is low in production cost and convenient to use, can be used for treating oral diseases, infective dermatosis and the like, receives good reputation from broad users, and has huge market value.
Owner:郭淮铨

Moxa floss quilt

The invention discloses a moxa floss quilt. The moxa floss quilt comprises a quilt shell and a quilt inner used for filling the quilt shell, wherein the quilt shell is formed by knitting yarns, the yarns are subjected to dip-dye in a liquid mixture before being knitted into the quilt shell, and the quilt inner is formed by mixing cotton fibers, polyester fibers and moxa floss; the quilt inner andthe quilt shell of the moxa floss quilt are rich in the active ingredients of artemisia argyi, so that the antibacterial and antiviral effects are achieved, meanwhile, the health care function is available, the cold-preventing efficacy is also available, and the resistance of the human body for diseases is enhanced; after cotton opening in cotton opening rooms of a multi-fiber cotton blending device, the cotton fibers, the polyester fibers and moxa floss are conveyed to a mixing box through an induced draft fan, after uniform mixing in the mixing box, the multi-fiber cotton blending device automatically completes the cotton opening and mixing process, and thus the work efficiency is improved; and for the multi-fiber cotton blending device, according to the different weights of the fiber materials in the cotton opening rooms, the air volume can be freely adjusted, so that the mixing is uniform, and the mixing effect is good.
Owner:刘国成

Anti-allergic handmade soap and preparation method thereof

The invention relates to anti-allergic handmade soap and a preparation method thereof. The handmade soap is composed of a transparent soap base, a traditional Chinese medicine extract and plant essential oil. The anti-allergic handmade soap adopts herba schizonepetae with flos lonicerae japonicae and herba menthae to play an anti-allergic effect, so that the prepared handmade soap is mild and small in irritation and suitable for people with allergies; and in the last step of preparing the traditional Chinese medicine extract, gypsum is added to act as a carrier, the traditional Chinese medicine component can be loaded onto the gypsum, then the traditional Chinese medicine extract is added when the handmade soap is manufactured, and the uniform dispersion of traditional Chinese medicine ingredients into the handmade soap is facilitated.
Owner:谢时京

A kind of edible mushroom lip balm and preparation method thereof

The invention belongs to the field of preparation of skin care products, and in particular relates to an edible mushroom lip balm and a preparation method thereof. In parts by weight, the raw materials include: 5-7 parts of straw mushrooms, 10-15 parts of shiitake mushrooms, 7-8 parts of shiitake mushrooms, 9-11 parts of coix seed extract, 12-13 parts of honey, 19-22 parts of beeswax, Almond oil 6‑8 parts. Immerse fresh straw mushrooms and shiitake mushrooms in the coix seed extract to efficiently extract the nutrients of straw mushrooms and shiitake mushrooms; soak the mushrooms in honey to fully integrate the viscose and nutrients on the surface of the mushrooms with the honey; The lip balm prepared by the method is rich in nutritional components of edible fungi, and can supplement various vitamins and the like required by dry lips, cleft lips and the like.
Owner:福建绿宝食品集团有限公司

Tricyclic compound with antihistamine activity, preparation method and application

The invention discloses a tricyclic compound with antihistamine activity, a preparation method and an application. The tricyclic compound with the antihistamine activity is named as N-(4-chlorocyclohexyl) desloratadine (I) and the structural formula is shown in the specification. An experiment verifies that the tricyclic compound with the antihistamine activity can be contestably combined with an organism H1 acceptor to block the effect between antihistamine and the organism H1, so that the antihistamine is prevented from expressing a biological effect and the antiallergic effect is realized. The experiment shows that the compound has stronger antihistamine activity and lower sedation side effects and anti-cholinergie side effects as compared with a positive control desloratadine.
Owner:TIANJIN UNIV

Skin care product for pregnant women and preparation method thereof

The invention provides a skin care product for pregnant women and a preparation method thereof. The preparation method comprises the following steps: adding iris leptophylla Lingelsh, vetiver and germinated quinoa into goat milk, mashing and uniformly mixing to obtain a mixed slurry, inoculating pseudoalteromonas, saccharomycetes and lactobacillus plantarum into the mixed slurry, fermenting to obtain a fermentation broth, adding sialic acid into the fermentation broth, ultrasonically oscillating uniformly to obtain a water phase; then taking moringa seeds, pomegranate seeds and indigo naturalis as raw materials, extracting to obtain mixed oil, then adding soybean lecithin, stirring and uniformly mixing to prepare an oil phase; and finally, slowly adding the water phase into the oil phase at a constant speed while stirring, stirring and emulsifying, and homogenizing to obtain the product. The skin care product provided by the invention adopts natural plant components, is mild and non-irritant, and has good use safety for pregnant women. The skin care product is a water-in-oil system, is more easily absorbed by human skin, plays a role in moisturizing, and effectively prevents and improves striae gravidarum.
Owner:唐美荣

Amber congealed fat and preparation method thereof

The invention discloses amber congealed fat and a preparation method thereof. The amber congealed fat is prepared from the following raw materials: deionized water, dipropylene glycol, butanediol, glyceryl polyether-26, carbomer, amber powder, an acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, allantoin, sodium carboxymethyl beta-glucan, beta-glucan, p-hydroxyacetophenone, arginine, a saccharide isomeride, a cactus extract and a radix ophiopogonis root extract. The composition is prepared from radix scutellariae extract, oat bran extract, polysorbate-20, capryloyl hydroxamic acid and essence. The amber congealed fat prepared by adopting special dosage matching has relatively good soothing and repairing effects, is very good in stability and is suitable for general people.
Owner:广州合众无纺化妆品集团有限公司

Anti-allergy toothpaste and preparation method thereof

The invention discloses anti-allergy toothpaste and a preparation method thereof. The anti-allergy toothpaste is prepared from the following components in parts by weight: 28 to 42 parts of a humectant, 0.5 to 2.5 parts of a wetting agent, 0.1 to 0.7 part of an adhesive, 0.1 to 0.7 part of a film-forming agent, 2 to 12 parts of hydroxyapatite, 1 to 5 parts of potassium nitrate, 0.01 to 0.15 part of tranexamic acid, 0.2 to 0.8 part of an emulsifier, 0.24 to 1.21 parts of sodium monofluorophosphate, 2 to 10 parts of cleaning type hydrated silica, 2 to 8 parts of thickening type hydrated silica, 0.10 to 0.35 part of a sweetening agent, 0.15 to 0.30 part of a preservative, 0.1-0.3 part of a friction agent, 1.2-3.2 parts of a surfactant, 0.2-0.7 part of a foaming agent, 0.4-1.5 parts of essence and 29-40 parts of a solvent, and the anti-allergic effect is good.
Owner:广州市名俐日用化工有限公司

Hemostatic sheet and production method thereof

The invention relates to a hemostatic sheet and a production method thereof. The hemostatic sheet comprises a backing layer, a medicine-carrying adhesive layer and an anti-sticking layer, wherein themedicine-carrying adhesive layer is composed of the following raw materials in parts by weight: 24 parts of an Argy wormwood extract, 15 parts of a Lalang grass flower extract, 7 parts of a plantain herb extract, 10 parts of a field thistle herb extract, 4 parts of sodium alginate, 14 parts of a pressure-sensitive adhesive, 10 parts of glycerin, and 32 parts of deionized water. According to the hemostatic patch, through the synergistic effect of all the components, the hemostatic effect is jointly achieved, the hemostasis is rapid, the wound healing can be accelerated, and meanwhile, inflammation diminishing and pain relieving can be performed on a wound. In addition, a certain anti-allergic effect can be achieved, and the situation that the skin around the wound is allergic due to long-time attachment is avoided.
Owner:徐州融创新材料技术研究院有限公司

Edible lipstick capable of nourishing lips and preparation method of lipstick

The invention belongs to the technical field of cosmetics for daily use and particularly relates to an edible lipstick capable of nourishing lips and a preparation method of the edible lipstick capable of nourishing lips. The edible lipstick capable of nourishing lips is prepared from components as follows: petals of impatiens balsamina, leaves of impatiens balsamina, petals of pomegranate flowers, sodium bicarbonate, wormwood, peach blossoms, pericarpium citri reticulatae, black tea, enteromorpha, a saline solution with the mass faction being 0.5%, clear water, boiled water, purified water, nanoscale pearl powder, olive oil and beeswax. The lipstick has the advantages that the prepared lipstick is safer to use, contains no toxic or harmful substances, is edible and has a nourishing effect on the lips.
Owner:QINGDAO HAIZHIXING BIOLOGICAL SCI & TECH

a perfume

The invention aims to provide perfume capable of reducing and even avoiding the volatizing of effective components. The perfume comprises, by weight, 75-90 parts of ethanol, 3-7 parts of water, 5-20 parts of glycerin-natural perfume mixture, wherein the glycerin-natural perfume mixture comprises 10-20wt% of glycerin and 80-90wt% of natural perfume. The perfume has the advantages that the difference of the effective component content of the natural perfume in the perfume of different batches is small, perfume quality can be controlled favorably, and large-scale production of high-end perfume is benefited; meanwhile, the raw material source of the perfume is strictly controlled, the perfume is natural and nonirritant, the skincare possibility of the perfume is increased, and the perfume has a certain anti-allergic effect.
Owner:HANGZHOU XINYUE COSMETICS CO LTD

Oral care mousse capable of inhibiting bacteria, preventing decayed teeth, whitening teeth, resisting allergy and removing peculiar smell

The invention relates to an oral care mousse capable of inhibiting bacteria, preventing decayed teeth, whitening teeth, resisting allergy and removing peculiar smell. The oral care mousse is characterized by consisting of the following raw materials in parts by weight: 0.1-0.5 part of a bacteriostatic agent, 0.2-0.8 part of a decayed teeth preventing substance, 1.0-5.0 parts of a tooth whitening substance, 1-10 parts of an oral mucosa adhesive, a film-forming agent and an anti-allergic substance, 0.1-2 parts of an odor removing substance, 0.1-0.5% of a foam reinforcing stabilizer, 1.0-5.0 parts of a surfactant, 0.1-0.2 part of a flavoring agent, 0.1-2 parts of essence, 5-20 parts of a humectant, 0.1-2 parts of a pH regulator and the balance of deionized water. The oral care mousse has the advantages that the oral care mousse has the functions of inhibiting bacteria, preventing decayed teeth, whitening teeth, resisting allergy, removing bad breath and the like, effective factors can act on oral mucosa and teeth for a long time by adding the oral mucosa adhesive and the film-forming agent to achieve efficacy, exposed dentinal tubules can be sealed, the anti-allergy effect is achieved, the functions are effectively integrated and do not interfere with one another, and conversion from the formula to the process and production is achieved.
Owner:WUHE KELING HEALTHCARE TECH

Traditional Chinese medicine composition for treating chronic eczema and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating chronic eczema and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following bulk drugs in parts by mass: 3-10 parts of herba schizonepetae, 5-60 parts of fructus forsythia, 3-30 parts of radix aconiti lateralis praeparata, 3-30 parts of radix et rhizoma glycyrrhizae, 5-60 parts of cortex mori, 3-30 parts of fructus corni, 5-60 parts of radix sophorae flavescentis, 5-60 parts of rhizoma smilacis glabrae, 5-30 parts of rhizoma atractylodis, 3-30 parts of pericarpium citri reticulatae, 5-60 parts of cortex moutan, 3-30 parts of flos carthami, 5-60 parts of radix angelicae sinensis, 5-60 parts of fructus kochiae, 5-60 parts of cortex dictamni, 5-60 parts of pheretima, 5-60 parts of ramulus uncariae cum uncis and 3-30 parts of periostracum cicadae. The traditional Chinese medicine composition can be used for treating chronic eczema, phase I clinical trial shows that the traditional Chinese medicine composition has a good curative effect on treating chronic eczema, the total effective rate reaches 85.71%, and no obvious adverse reaction is observed.
Owner:马淑然
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